Ancient DNA reveals pervasive directional selection across West Eurasia | Nature
May 31, 2026https://www.nature.com/articles/s41586-026-10358-1
Akbari, A., Perry, A., Barton, A. R., Kariminejad, M., Gazal, S., Li, Z., Zeng, Y., Mittnik, A., Patterson, N., Mah, M., Zhou, X., Price, A. L., Lander, E. S., Pinhasi, R., Rohland, N., Mallick, S., & Reich, D. (2026). Ancient DNA reveals pervasive directional selection across West Eurasia. Nature. https://doi.org/10.1038/s41586-026-10358-1
How effective is the personalized off-label use of targeted cancer treatment?
May 31, 2026https://www.nature.com/articles/d41586-026-00911-3
NEWS AND VIEWS
15 April 2026
How effective is the personalized off-label use of targeted cancer treatment If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?
By Funda Meric-Bernstam
Yoda1 and Dooku1 drugs for allergy – Google Search
May 31, 2026https://www.google.com/search?q=Yoda1+and+Dooku1+drugs+for+allergy&sca_esv=bf92bea0edb6a6be&sxsrf=ANbL-n4FnhlgiZOg1P6XGD-CH0nQWDfQDw%3A1780270742370&ei=lsYcarirFpDaptQPiY7EwAU&biw=1307&bih=712&ved=0ahUKEwi4zs-p2eSUAxUQrYkEHQkHEVgQ4dUDCBA&uact=5&oq=Yoda1+and+Dooku1+drugs+for+allergy&gs_lp=Egxnd3Mtd2l6LXNlcnAiIllvZGExIGFuZCBEb29rdTEgZHJ1Z3MgZm9yIGFsbGVyZ3kyBRAAGO8FMgUQABjvBTIIEAAYgAQYogQyBRAAGO8FSLZAUABYlylwAHgBkAEAmAFloAGMBaoBAzUuMrgBA8gBAPgBAvgBAZgCB6ACrAXCAgoQIRgKGKABGMMEmAMAkgcDMy40oAeaF7IHAzMuNLgHrAXCBwUxLjQuMsgHD4AIAQ&sclient=gws-wiz-serp QT:{{” Yoda1 and Dooku1 are not approved medications for allergy patients; they are purely experimental chemical tools used in scientific research. They are studied to understand the behavior of PIEZO1, a mechanosensitive ion channel found in cells like mast cells and airway smooth muscle cells. [1, 2, 3, 4, 5, 6]
Yoda1: Acts as a synthetic agonist, meaning it forcefully opens the PIEZO1 channel. In allergy and asthma research, stimulating this channel with Yoda1 can cause mast cell degranulation (triggering histamine release) or, conversely, relax airway smooth muscle cells to potentially cause bronchodilation. [1, 2, 3]
Dooku1: Acts as an antagonist, meaning it blocks Yoda1 from opening the PIEZO1 channel. In research, it is used to reverse or inhibit the effects of
“}}
Probiotic Bread Could Be the Recipe for Asthma Relief | Respiratory Therapy
May 31, 2026https://respiratory-therapy.com/disorders-diseases/chronic-pulmonary-disorders/asthma/probiotic-bread-recipe-asthma-relief/ QT:{{”
Brazilian researchers have created a functional bread containing a probiotic strain of yeast, Saccharomyces cerevisiae UFMG A-905, which has shown potential in preventing asthma by reducing airway
inflammation and asthma biomarkers in mice.
“}}
Journal of Medical Internet Research – From Virtual Molecules to Clinical Trials: How AI Is Reshaping Preclinical Drug Discovery
May 31, 2026https://www.jmir.org/2026/1/e101366
QT:{{”
Mark Gerstein, PhD—professor of biomedical informatics, molecular biophysics, and computer science at Yale University—said that this paradox helps explain why enthusiasm around AI should be tempered with realism. “There is a lot of excitement with AI in drug discovery,” Gerstein said, “but the reality is that we have not been as successful at discovering drugs as we would have hoped.”
…Gerstein also points to equivariant neural networks as a promising advance in AI-driven drug discovery. Since molecules obey physical laws and can rotate, stretch, or change their conformation, predictive models must account for these transformations. Equivariant
architectures are designed to preserve these relationships, making them especially valuable for molecular modeling and binding prediction “}}
Cuffari, B. (2026). From virtual molecules to clinical trials: How AI is reshaping preclinical drug discovery. Journal of Medical Internet Research, 28, e101366. https://doi.org/10.2196/101366
Massimo on X: “Nikola Tesla invented this valve over a century ago, and NASA still uses the same idea today. A brilliant piece of engineering without moving parts that allows fluid to flow easily in one direction but creates massive resistance to reverse flow. https://t.co/pqleg1pAtu” / X
May 31, 2026https://x.com/Rainmaker1973/status/2060636673587691831
QT:{{” Nikola Tesla invented this valve over a century ago, and NASA still uses the same idea today. A brilliant piece of engineering without moving parts that allows fluid to flow easily in one direction but creates massive resistance to reverse flow. “}}
