https://www.nature.com/articles/nmeth.4627
interpretable deep learning model
Posts Tagged ‘jclub’
Using deep learning to model the hierarchical structure and function of a cell | Nature Methods
September 18, 2021Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression | Bioinformatics | Oxford Academic
May 3, 2021Nice analysis integrating bulk & single-cell data, to get at inter-individual differences in the expression of genes in specific
cell types https://academic.OUP.com/bioinformaticsformatics/article/36/3/782/5545976
Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression
https://academic.oup.com/bioinformatics/article/36/3/782/5545976
ADORA1 Gene – GeneCards | AA1R Protein | AA1R Antibody
October 12, 2019Journal Club by JG
July 27, 2018TWAS of 229k women identifies new candidate susceptibility genes for breast cancer https://www.Nature.com/articles/s41588-018-0132-x Metascan approach. Derive model for imputing transcriptome from #GTEx & validate against TCGA. Application to BCAC.
Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder | Nature Neuroscience
July 27, 2018Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease
Today: Jason Moore, Computational Biology and Bioinformatics speaker, 6-6-18 in BML Auditorium at 4 pm
June 7, 2018Papers for Journal Club
June 7, 2018Alternative evolutionary histories in the sequence space of an ancient protein https://www.Nature.com/articles/nature23902 Great viz of different potential but not necessarily realized evolutionary trajectories. Quite relevant for molecular #evolution & #pseudogenes
Paper for Journal Club Tomorrow
May 22, 2018Susceptibility of brain atrophy to TRIB3 in #Alzheimer’s disease, evidence from functional prioritization in imaging genetics
http://www.PNAS.org/content/115/12/3162.long Nice connection of developing phenotypes from #imaging, combined w. simple polygenic scores from genotypes
ADNI Website
May 20, 2018Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies – ScienceDirect
April 28, 2018Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly
