Most Guests Ducked for Cover. This Man Munched on His Burrata Salad. – The New York Times
https://www.nytimes.com/2026/04/26/us/politics/man-salad-white-house-correspondents-dinner.html
Most Guests Ducked for Cover. This Man Munched on His Burrata Salad.
April 28, 20264 Drugs That May Increase Your Dementia Risk
April 28, 2026QT:{{”
Antihistamines
The class of medications with perhaps the most evidence of raising dementia risk are called anticholinergics. ….
“That once-in-a-while use of Benadryl is unlikely to increase risk for dementia,” Dr. Gray said. …
So-called second generation antihistamines, like Claritin and Zyrtec, don’t have anticholinergic activity, so they can be a safer option for seasonal allergies,
Antipsychotic Drugs
With mental health medications and dementia, there is a chicken-or-egg question: Do the drugs themselves increase the risk of dementia, or is it the conditions the drugs are prescribed for, such as depression or psychosis, that increase it? ….
Benzodiazepines
These mental health medications, which work on a specific
neurotransmitter to suppress brain activity, have also been linked to dementia…..
Proton Pump Inhibitors
Conflicting evidence has also been reported about proton pump inhibitors, which are often used to treat acid reflux. … Some proton pump inhibitors, like Prilosec, are purchased over the counter, so their use can be more difficult to track and analyze than prescription medications.
“}}
The New York Times
https://www.nytimes.com/2026/04/22/well/mind/medications-dementia-risk-increase.html
A mechanism for adaptive genome regulation in cancer | Nature
April 25, 2026https://www.nature.com/articles/s41586-026-10269-1
Nice discussion of discrete cell types v cont. cell states
QT:{{”
Although the transcriptomic classification of cell types and states into discrete hierarchical entities is useful for standardizing and recogniz- ing functional units8, this framework could risk the reinforcement of a Platonic view, in which observed states are viewed as approximations to idealized configurations underpinned by strict gene programs (Fig. 1a). The advent of single-cell RNA sequencing has provided evidence for the notion that cells often traverse continuous and multidimensional landscapes of gene expression, shaped by varying degrees of constraint and plasticity. Such dynamics are an inherent cellular attribute that also occurs in seemingly stable physiological states, and processes in normal physiology once thought to involve binary choices are now recognized as continuous (Fig. 1b). For example, haematopoiesis reflects gradual acquisition of lineage biases rather than transitions between discrete progenitor states9. Epithelial-to-mesenchymal transition (EMT) proceeds through multiple intermediate hybrid states with context-specific tran- scriptional profiles10. Waddington’s well-known epigenetic landscape metaphor, where cells roll down a fixed, branching landscape during cell-fate decisions and settle at valleys corresponding to stable inter- mediate or terminally differentiated states, may not fully capture the continuity of cellular-state transitions11. Instead, the landscape itself appears to be flexible, especially in disease contexts, with environmental and genetic changes reshaping the accessibility of states, thus changing the barriers that govern cell-state transitions (Fig. 1c). “}}
França, G. S., & Yanai, I. (2026). A mechanism for adaptive genome regulation in cancer. Nature, 652(8110), 581–590.
https://doi.org/10.1038/s41586-026-10269-1
Harnessing AI to Build Virtual Cells | bioRxiv
April 25, 2026Harnessing AI to Build Virtual Cells | bioRxiv
https://www.biorxiv.org/content/10.64898/2026.04.11.717183v1
how much is a thousand, a million and then a billion seconds – Google Search
April 25, 202617min, 12days, 32yrs
https://www.google.com/search?q=how+much+is+a+thousand%2C+a+million+and+then+a+billion+seconds&sca_esv=8f676378753648eb&rlz=1C5CHFA_enUS1047US1048&biw=1294&bih=798&sxsrf=ANbL-n631RbCMptnFXbBkC93WdiDJxCUYw%3A1777169291224&ei=i3PtaYKwDZWi5NoPrvekiQ0&ved=0ahUKEwjCobzCt4qUAxUVEVkFHa47KdEQ4dUDCBE&uact=5&oq=how+much+is+a+thousand%2C+a+million+and+then+a+billion+seconds&gs_lp=Egxnd3Mtd2l6LXNlcnAiPGhvdyBtdWNoIGlzIGEgdGhvdXNhbmQsIGEgbWlsbGlvbiBhbmQgdGhlbiBhIGJpbGxpb24gc2Vjb25kczIFECEYoAEyBRAhGKABMgUQIRigATIFECEYqwIyBRAhGKsCMgUQIRirAki3OFDhBljDJXADeAGQAQCYAV-gAdYHqgECMTW4AQPIAQD4AQGYAhGgAsYHwgIKEAAYRxjWBBiwA8ICBxAjGLACGCfCAggQABiABBiiBMICCBAAGIkFGKIEwgIFEAAY7wXCAgQQIRgKmAMAiAYBkAYIkgcCMTegB85KsgcCMTS4B7wHwgcFMi44LjfIBymACAE&sclient=gws-wiz-serp QT:{{” A thousand seconds is about 16.7 minutes, a million seconds is approximately 11.6 days, and a billion seconds is roughly 31.7 years “}}
Allergy Season Report for Branford, CT (06405) | Pollen.com
April 23, 2026[tags useful,hl0g]
https://www.pollen.com/research/06405
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linkstream2 microblog 