Bouba/kiki effect – Wikipedia
March 29, 2026Oral Semaglutide: How It Works, Side Effects, & More | Ro
March 29, 2026https://ro.co/weight-loss/oral-semaglutide/
a new pill
Should We All Be ‘House Burping’? – The New York Times
March 29, 2026https://www.nytimes.com/2026/01/29/realestate/what-is-house-burping-luften.html
QT:{{”
In the last few weeks, an unfamiliar German term may have surfaced on your social media feeds. “Lüften” roughly translates to “ventilate” or “airing out” and involves just that — opening windows in your home once or twice a day, regardless of the outside temperature, to eliminate stale air.
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NYTimes: ‘How Low Can You Go?’ The Shifting Guidelines for Blood Pressure Control
March 29, 2026Nash
https://www.nytimes.com/2026/03/14/health/blood-pressure-guidelines-hypertension-dementia.html
QT:{{”
For more than 25 years, a reading of 140/90 or below was considered normal, according to the A.H.A./A.C.C. guidelines. But the 2017 update introduced major changes, backed by results from the landmark Sprint trial, which enrolled adults over 50 who were at high cardiovascular risk.
The Sprint trial found that intensive treatment aimed at bringing the systolic number below 120 reduced the risk of heart attacks, strokes, other cardiovascular illnesses and overall mortality so substantially that the investigators stopped the study early.
It was unethical, they decided, to deny half the trial participants the benefits of intensive treatment. The 2017 guidelines, therefore, recommended medication for those with a systolic blood pressure over 130.
The most recent revisions, issued late last year, encourage still tighter control. They call for patients at cardiovascular risk to strive for systolic readings below 120, and they also call that target “reasonable” even for those who are not at high risk. Readings considered normal not so long ago are now defined as hypertension. “}}
A Day in the Pre-Internet World, as Understood by Someone Born in 2002 | The New Yorker
March 29, 2026Huntington disease – PubMed
March 29, 2026https://pubmed.ncbi.nlm.nih.gov/27188817/
ASO v RNAi v siRNA
QT:{{”
how a specific toxic conformation might be favoured
within the expanded polyQ of monomeric HTT exon1
is unclear37,47. More-complex conformational effects in
monomeric HTT exon1 linked to polyQ repeat length
are formally possible but challenging to establish37,49. By
contrast, the widely reported ability of HTT exon1 to
readily form a variety of aggregated structures presents
an array of plausible candidates that might mediate toxicity (see below)37. This aggregation links Huntington
disease to other neurodegenerative diseases that feature
a protein aggregation component, including Alzheimer
disease, Parkinson disease, amyotrophic lateral sclerosis
and spongiform encephalopathies.
…
bind to HTT mRNA selectively and target it for degradation
by cellular mechanisms. When the agent is a short
interfering RNA (siRNA) or microRNA, the HTT
mRNA is degraded by cytoplasmic RNA-induced silencing
complex (RISC) — a process known as RNA interference
(RNAi). Alternatively, a single-stranded modified
DNA molecule or antisense oligonucleotide (ASO) can
be used to direct the transcript for degradation by
nuclear ribonuclease H.
“}}
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., Nance, M., Ross, C. A., Scahill, R. I., Wetzel, R., Wild, E. J., & Tabrizi, S. J. (2015). Huntington disease. Nature Reviews Disease Primers, 1(1), 15005.
https://doi.org/10.1038/nrdp.2015.5
from G search {{
”
Yes, amyloid fibrils in Huntington’s disease (HD) contain a specific protein—the mutated huntingtin (Htt) protein. These fibrils are formed specifically from the N-terminal exon 1 fragment of the mutant protein, which contains an expanded polyglutamine (polyQ) tract that forms the amyloid core.
….
Although they contain the mutant protein, the amyloid fibrils in HD are distinct from those in Alzheimer’s (A
) or Parkinson’s (
-synuclein) diseases.
”
}}
smoldering myeloma – Google Search
March 29, 2026PureCare Cooling SoftCell Chill Latex Pillow – Standard | Raymour & Flanigan
March 29, 2026https://www.raymourflanigan.com/pillows/memory-foam-pillows/purecare-cooling-softcell-chill-latex-pillow-standard-498061630 one side soft and other firm
Solar System | NOVA | PBS
March 29, 2026https://www.pbs.org/wgbh/nova/series/solar-system/episodes/
saw 3/4 : volcano, ice worlds, strange worlds
linkstream2 microblog 