Posts Tagged ‘x78qtcore’
Sequenced genomes reveal mutations that disable single genes and can point to new drugs.
28 October 2014 Corrected:
29 October 2014
You should also read the Corrections to this article
The poster child for human-knockout efforts is a new class of drugs that block a gene known as PCSK9 (see Nature 496, 152–155; 2013). The gene was discovered in French families with extremely high cholesterol levels in the early 2000s. But researchers soon found that people with rare mutations that inactivate one copy ofPCSK9 have low cholesterol and rarely develop heart disease. The first PCSK9-blocking drugs should hit pharmacies next year, with manufacturers jostling for a share of a market that could reach US$25 billion in five years.
“I think there are hundreds more stories like PCSK9 out there, maybe even thousands,” in which a drug can mimic an advantageous
loss-of-function mutation, says Eric Topol, director of the Scripps Translational Science Institute in La Jolla, California. Mark Gerstein, a bioinformatician at Yale University in New Haven, Connecticut, predicts that human knockouts will be especially useful for identifying drugs that treat diseases of ageing. “You could imagine there’s a gene that is beneficial to you as a 25-year-old, but the thing is not doing a good job for you when you’re 75.”
The Chronicle of Higher Education
BioTechniques – The Myth of the Single Genome
The Myth of the Single #Genome: fetal Y chr left in women + smaller microchimerism in specific tissues
http://www.biotechniques.com/news/The-Myth-of-the-Single-Genome/biotechniques-347272.html MT @xberthet
A post in Science Careers discussed type of collaborative environment in the lab.
June 16, 2013
Poking Holes in Genetic Privacy
By GINA KOLATA
Not so long ago, people who provided DNA in the course of research studies were told that their privacy was assured. Their DNA sequences were on publicly available Web sites, yes, but they did not include names or other obvious identifiers. These were research databases, scientists said, not like the forensic DNA banks being gathered by the F.B.I. and police departments.
Experts were startled by what Dr. Erlich had done. “We are in what I call an awareness moment,” said Eric D. Green, director of the National Human Genome Research Institute at the National Institutes of Health.
Research subjects who share their DNA may risk a loss of not just their own privacy but also that of their children and grandchildren, who will inherit many of the same genes, said Mark B. Gerstein, a Yale professor who studies large genetic databases.
Where once there was the genome, now there are thousands of ’omes.
Nature goes in search of the ones that matter.
by Monya Baker
27 February 2013Contains an interesting ‘omes crossword
http://yalemedicine.yale.edu/winter2013//features/feature/145468 Yale scientists played a leading role in an international effort to map the 99 percent of the human genome that doesn’t produce
proteins—perhaps ending the notion that those regions are “junk.” By Colleen Shaddox
http://www.nature.com/news/big-biology-the-omes-puzzle-1.12484?WT.ec_id=NATURE-20130228 Where once there was the genome, now there are thousands of ’omes. Nature goes in search of the ones that matter.
by Monya Baker
27 February 2013