Posts Tagged ‘pseudogene’

Genome expansion via lineage splitting and genome reduction in the cicada endosymbiont Hodgkinia

February 13, 2017

Genome expansion via lineage splitting…in the cicada endosymbiont Hodgkinia http://www.PNAS.org/content/112/33/10192.abstract Host lifecycle partially enables split

Eat, Pray, Latin – The New Yorker

August 19, 2016

Eat, pray, #Latin
http://www.NewYorker.com/culture/cultural-comment/eat-pray-latin “An undead language, a ghost shadowing…our words, a zombie…in sentences,” viz pseudolanguage!

Pseudoenzyme – Proteopedia, life in 3D

August 2, 2015

QT:{{”
Pseudoenzymes are proteins that cannot catalyze chemical reactions despite being clearly related structurally to functioning enzymes. Many enzyme families contain inactive members. For example, a number of human kinases lack at least one of the key amino acids necessary for catalysis of phosphate transfer [1]. Often pseudoenzymes still have biological roles, albeit non-catalytic. Some assist true enzymes in obtaining functional folds, some server as platforms for other proteins to interact, and some are escorts for proteins [2][3]. “}}

http://proteopedia.org/wiki/index.php/Pseudoenzyme

New lives for old: evolution of pseudoenzyme function illustrated by iRhoms : Abstract : Nature Reviews Molecular Cell Biology

August 2, 2015

– pseudoenzyme

http://www.nature.com/nrm/journal/v13/n8/abs/nrm3392.html

Genome-wide identification of pseudogenes capable of disease-causing gene conversion. – PubMed – NCBI

August 2, 2015

http://www.ncbi.nlm.nih.gov/pubmed/16671097

The structure, function and evolution of proteins that bind DNA and RNA : Nature Reviews Molecular Cell Biology : Nature Publishing Group

June 10, 2015

http://www.nature.com/nrm/journal/v15/n11/full/nrm3884.html

NATURE REVIEWS MOLECULAR CELL BIOLOGY | ANALYSIS
William H. Hudson
& Eric A. Ortlund
Nature Reviews Molecular Cell Biology 15, 749–760 (2014) doi:10.1038/nrm3884

BRAF pseudogene and cancer development

April 17, 2015

BRAF #Pseudogene Functions as a Competitive Endogenous RNA; [Shows it] induces Lymphoma [after alteration, in mice]
http://www.cell.com/cell/abstract/S0092-8674(15)00244-5

Cell. 2015 Apr 9;161(2):319-32. doi: 10.1016/j.cell.2015.02.043. Epub 2015 Apr 2.

Karreth FA1, Reschke M1, Ruocco A1, Ng C1, Chapuy B2, Léopold V1, Sjoberg M3, Keane TM3, Verma A4, Ala U1, Tay Y1, Wu D5, Seitzer N1, Velasco-Herrera Mdel C3, Bothmer A1, Fung J1, Langellotto F6, Rodig SJ7, Elemento O4, Shipp MA2, Adams DJ3, Chiarle R8, Pandolfi PP9.

Abstract
Research over the past decade has suggested important roles for pseudogenes in physiology and disease. In vitro experiments
demonstrated that pseudogenes contribute….

Circle of life

November 15, 2014

the "circle of life"

http://www.sciencedirect.com/science/article/pii/S0960982214001547#

Volume 24, Issue 6, pR238–R240, 17 March 2014

Evolution: Dynamics of De Novo Gene Emergence

Rafik Neme
Diethard Tautz

DOI: http://dx.doi.org/10.1016/j.cub.2014.02.016

Myosin gene mutation correlates with anatomical changes in the human lineage : Abstract : Nature

July 23, 2014

From S Caroll, “Many approaches are being taken, and a few intriguing associations of candidate genes and the evolution of particular traits have been discovered, such as the…MYH16 muscle-specific myosin pseudogene and the evolutionary reduction of the masticatory apparatus.”

QT:{{”

Powerful masticatory muscles are found in most primates, including chimpanzees and gorillas…. In contrast, masticatory muscles are considerably smaller in both modern and fossil members of Homo. …Here, we show that the gene encoding the predominant myosin heavy chain (MYH) expressed in these muscles was inactivated by a
frameshifting mutation after the lineages leading to humans and chimpanzees diverged. Loss of this protein isoform is associated with marked size reductions in individual muscle fibres and entire masticatory muscles. Using the coding sequence for the myosin rod domains as a molecular clock, we estimate that this mutation appeared approximately 2.4 million years ago.

“}}

http://www.nature.com/nature/journal/v428/n6981/abs/nature02358.html

Pseudogene expression in TCGA data

July 11, 2014

http://www.nature.com/ncomms/2014/140707/ncomms4963/full/ncomms4963.html

The Pan-Cancer analysis of pseudogene expression reveals biologically and clinically relevant tumour subtypes

Leng Han
Yuan Yuan
Siyuan Zheng
Yang Yang
Jun Li
Mary E. Edgerton
Lixia Diao
Yanxun Xu
Roeland G. W. Verhaak
Han Liang