Posts Tagged ‘x78twee’
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314570 as ref. to current annotation in human
Below is key ref.
## From Brenner talk at ISMB:
Argues that domain trunc prot have a dom. neg pheno.
(ex binding domain for reg & tf or sox10)
NMD fixes this; truncated case now looks like hemizyg.
## Related twitter dialogue:
Brenner: expl. how premature truncation is often a dominant neg. (ex SOX10), providing a rationalization for the purpose of NMD #ISMB #LBR01
@rtraborn · Jul 13
Why would cells generate mRNA that are then immediately degraded by NMD? Brenner suggests that this process has a regulatory function #ISMB
@raarjr · Jul 13
Brenner: 50 nt rule accurately predicts NMD, and is prevalent in auto regulation.so what’s our ruler? #ismb
Mol Gen Genet. 1998 Nov;260(2-3):176-84.
mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.
Cali BM, Anderson P.
Linial: ClanTox (www.clantox.cs.huji.ac.il) to classify short peptides as toxins. #ismb #kn1
TOLIPS relevant to brain, neuropeptides
Linial mentions NeuroPID: a predictor for identifying neuropeptide precursors from metazoan proteomes
http://bioinformatics.oxfordjournals.org/content/early/2014/03/05/bioinformatics.btt725.abstract #ismb #kn1