Posts Tagged ‘x78twee’

The 8q24 cancer risk variant rs6983267 shows long-range interaction with : MYC: in colorectal cancer : Abstract : Nature Genetics

April 26, 2015

http://www.nature.com/ng/journal/v41/n8/abs/ng.403.html

Advertisements

Fighting a One-of-a-Kind Disease

October 24, 2014

http://www.newyorker.com/magazine/2014/07/21/one-of-a-kind-2

BMC Bioinformatics | Full text | GAPscreener: An Automatic Tool for Screening Human Genetic Association Literature in PubMed Using the Support Vector Machine Technique

October 24, 2014

http://www.biomedcentral.com/1471-2105/9/205

Is everything we eat associated with cancer? A systematic cookbook review

October 24, 2014

http://ajcn.nutrition.org/content/97/1/127.long

Primates and mouse NumtS in the UCSC Genome Browser

October 24, 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3314570 as ref. to current annotation in human

The genomic landscape of polymorphic human nuclear mitochondrial insertions | bioRxiv

October 24, 2014

http://biorxiv.org/content/early/2014/08/19/008144

PLOS Computational Biology: Analysis of Stop-Gain and Frameshift Variants in Human Innate Immunity Genes

October 24, 2014

http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003757

Methods for Detecting Associations with Rare Variants for Common Diseases: Application to Analysis of Sequence Data

October 24, 2014

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2842185 #ASHG14

mRNA surveillance mitigates genetic dominance … Mol Gen Genet. 1998 – PubMed – NCBI

July 19, 2014

Below is key ref.

## From Brenner talk at ISMB:

Argues that domain trunc prot have a dom. neg pheno.
(ex binding domain for reg & tf or sox10)

NMD fixes this; truncated case now looks like hemizyg.

## Related twitter dialogue:

Brenner: expl. how premature truncation is often a dominant neg. (ex SOX10), providing a rationalization for the purpose of NMD #ISMB #LBR01

@rtraborn · Jul 13
Why would cells generate mRNA that are then immediately degraded by NMD? Brenner suggests that this process has a regulatory function #ISMB

@raarjr · Jul 13
Brenner: 50 nt rule accurately predicts NMD, and is prevalent in auto regulation.so what’s our ruler? #ismb

## REF

http://www.ncbi.nlm.nih.gov/pubmed/9862469

Mol Gen Genet. 1998 Nov;260(2-3):176-84.

mRNA surveillance mitigates genetic dominance in Caenorhabditis elegans.

Cali BM, Anderson P.

NeuroPID: a predictor for identifying neuropeptide precursors from metazoan proteomes

July 19, 2014

Linial: ClanTox (www.clantox.cs.huji.ac.il) to classify short peptides as toxins. #ismb #kn1

TOLIPS relevant to brain, neuropeptides

Linial mentions NeuroPID: a predictor for identifying neuropeptide precursors from metazoan proteomes
http://bioinformatics.oxfordjournals.org/content/early/2014/03/05/bioinformatics.btt725.abstract #ismb #kn1