https://www.cell.com/cell/fulltext/S0092-8674(21)01279-4
A single-cell atlas of chromatin accessibility in the human genome
Kai Zhang 8
James D. Hocker 8
Michael Miller
….
Allen Wang
Sebastian Preissl
Bing Ren 9
Published:November 12, 2021
DOI:https://doi.org/10.1016/j.cell.2021.10.024
https://news.yale.edu/2020/07/30/insights-outcomes-new-spin-quantum-research-and-biology-sex
QT:{{”
ENCODE and the dance between genes and DNA/RNA
Since 2003, the lab of Yale’s Mark Gerstein has played a major role in an international effort to catalog data on the complex interactions between genes and the segments of DNA and RNA that regulate their functions. The latest findings of the ENCODE project were published July 29 in 30 papers, four spearheaded by Gerstein’s lab, in a variety of scientific journals. Jing Zhang and Donghoon Lee from Gerstein’s lab have created a video illustrating science’s evolving understanding of the complex regulatory networks that can contribute to cancer and other diseases. The latest findings by the Gerstein lab and other major ENCODE contributors can be found on the Gerstein lab website. “}}
https://www.ncbi.nlm.nih.gov/pubmed/30612741
crisprQTL
crisprQTL mapping as a genome-wide association framework for cellular genetic screens
Molly Gasperini, Andrew J. Hill, José L. McFaline-Figueroa, Beth Martin, Cole Trapnell, Nadav Ahituv, Jay Shendure
doi: https://doi.org/10.1101/314344
SCIENTIFIC AMERICAN MARCH 2019
Untangling the Formation of DNA Loops
New discoveries on ancient loops in DNA offer clues into gene regulation
By Erez Lieberman Aiden
https://www.scientificamerican.com/article/untangling-the-formation-of-dna-loops/
Changes in gene activity may one day reveal…time of death
https://www.ScienceMag.org/news/2018/02/changes-gene-activity-may-one-day-reveal-time-death-crime-victims Discusses paper by @RodericGuigo (“Effects of death & post-mortem cold ischemia on….#transcriptomes,”
https://www.Nature.com/articles/s41467-017-02772-x). Obvious forensic interest but maybe a #privacy angle as well
Changes in gene activity may one day reveal the time of death for crime victims
quite relevant
https://www.nature.com/articles/nmeth.4534
Resolving systematic errors in widely used enhancer activity assays in human cells
Felix Muerdter
, Łukasz M Boryń
, Ashley R Woodfin
, Christoph Neumayr
, Martina Rath
, Muhammad A Zabidi
, Michaela Pagani
, Vanja Haberle
, Tomáš Kazmar
, Rui R Catarino
, Katharina Schernhuber
, Cosmas D Arnold
& Alexander Stark
Nature Methods volume 15, pages141–149 (2018)
Received: 13 November 2017 Revised: 22 November 2017 Accepted: 29 November 2017 https://www.nature.com/articles/s41525-017-0040-5.pdf
https://my.pgp-hms.org/profile/hu43860C
George Church discloses a lot of his medical records
linkstream2 microblog 