Posts Tagged ‘x78retwee’

Using Benford’s Law to Detect Bitcoin Manipulation

August 1, 2021

https://mindmatters.ai/2021/07/using-benfords-law-to-detect-bitcoin-manipulation/

Therefore, this is the distribution expected if the logarithms of the numbers (but not the numbers themselves) are uniformly and randomly distributed.
https://en.wikipedia.org/wiki/Benford%27s_law

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science

July 17, 2021

https://science.sciencemag.org/content/369/6510/1501

BY CHING-LIN HSIEH, JORY A. GOLDSMITH, JEFFREY M. SCHAUB, ANDREA M. DIVENERE, HUNG-CHE KUO, KAMYAB JAVANMARDI, KEVIN C. LE, DANIEL WRAPP, ALISON G. LEE, YUTONG LIU, CHIA-WEI CHOU, PATRICK O. BYRNE, CHRISTY K. HJORTH, NICOLE V. JOHNSON, JOHN LUDES-MEYERS, ANNALEE W. NGUYEN, JUYEON PARK, NIANSHUANG WANG, DZIFA AMENGOR, JASON J. LAVINDER, GREGORY C. IPPOLITO, JENNIFER A. MAYNARD, ILYA J. FINKELSTEIN, JASON S. MCLELLAN

SCIENCE18 SEP 2020 : 1501-1505

The design of stabilizing mutations in the SARS-CoV-2 spike protein allows for high-yield production of a critical vaccine antigen.

In particular,
stabilization is very important for the Moderna vaccine design.

This work builds on :
{{”
Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283.

Structure-based design of a fusion glycoprotein vaccine for
respiratory syncytial virus

Jason S McLellan 1, Man Chen, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W Graepel, Azad Kumar, Syed Moin, Jeffrey C Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S Graham, Peter D Kwong
Affiliations expand

PMID: 24179220 PMCID: PMC4461862 DOI: 10.1126/science.1243283 https://pubmed.ncbi.nlm.nih.gov/24179220/
“}}

The unseen covid-19 risk for unvaccinated people

July 17, 2021

This is the first newspaper article I’ve seen with a *methods* section at the end (which describes how #covid19 death rates could be “adjusted” for vaccine status)

https://www.washingtonpost.com/health/interactive/2021/covid-rates-unvaccinated-people

The unseen covid-19 risk for unvaccinated people

By Dan Keating and Leslie Shapiro

This story was published a few weeks ago but remains incredibly important as the delta variant spreads throughout the U.S.

The country’s declining covid-19 case rates present an unrealistically optimistic perspective for half of the nation — the half that is still not vaccinated.

As more people receive vaccines, covid-19 cases are occurring mostly in the increasingly narrow slice of the unprotected population. So The Washington Post adjusted its case, death and hospitalization rates to account for that — and found that in some places, the virus continues to rage among those who haven’t received a shot. Read more »

Cauliflower and Chaos, Fractals in Every Floret – The New York Times

July 16, 2021

Caused by 2 genes
https://www.nytimes.com/2021/07/08/science/cauliflower-fractals.html

Biology begins to tangle with quantum computing | Nature Methods

July 16, 2021

Technology Feature
Published: 23 June 2021
Biology begins to tangle with quantum computing
Vivien Marx
Nature Methods volume 18, pages715–719 (2021)

QT:{{”

“There’s a lot of buzz about quantum computing,” says Yale University researcher Mark Gerstein, whose projects traverse biology and informatics. Enthusiasm among his colleagues about the prospects of quantum computing is especially high in the physical sciences, and interest is growing in computational biology and biology more generally.


Gerstein co-authored a paper4 that grew from a series of discussions at the National Institute of Mental Health (NIMH), part of the US National Institutes of Health (NIH). It’s part of the NIH’s way of exploring how to support biologists interested and involved in quantum computing, he says. The wider neuroscience community, for example, is interested in how quantum approaches can be applied to deep learning and machine learning.

“}}

https://www.nature.com/articles/s41592-021-01199-z

Digital secrets of successful lab management

July 16, 2021

QT:{{”
“Ironically, a lot of these tools are about not having people sit in front of a screen all the time,” says computational biologist Mark Gerstein at Yale University in New Haven, Connecticut. “I don’t think that helps people think.” Instead, he says, researchers spawn creativity when talking and scribbling down ideas together, be that on a phone, tablet, laptop or in person.

Like Brown, Gerstein prizes face-to-face conversation and
collaboration in his group, which works on large-scale analyses of biosensor and wearable data. As such, it attracts “hard-core computer geeks”, he says, so he’s thought deeply about how to entice them out from behind their screens.

“Computers now let us dictate, write and draw with our hands in much more relaxing and natural ways,” he says. Gerstein sets his phone on a nearby table, then uses Google Recorder to capture discussions, and the app (which is available only on Pixel phones) transcribes it in real time. The transcript is coupled to the audio and can be searched by keyword. Another dictation app, known as Rev, offers
quick-turnaround manual transcriptions for $1.25 per minute of recording. Gerstein also uses the app Grammarly to “take the yucky voice-to-text transcript and fix the language up quickly”.

Gerstein describes his group’s use of these tools together as a “stack” to go from conversation to a rough draft of a manuscript in just a few clicks, he says. He estimates that the tools cut the time they spent on that task in half.

Gerstein has also investigated tools that digitally recreate the experience of scientists gathered around a whiteboard. Zoom’s Annotate feature is one option, which he has deployed during remote meetings both before and during the pandemic. Another is Rocketbook, a reusable physical notebook ($16–45) that has whiteboard-like paper paired with a mobile-phone app that converts photos of notebook scribbles, cartoons and diagrams into digital files. Both Rocketbook and Google Lens use optical character recognition to interpret handwriting and translate it into searchable text. “I’ve saved thousands of sheets of paper this way,” says Gerstein.

“}}

https://www.nature.com/articles/d41586-021-01752-y

Improving ventilation will help curb SARS-CoV-2 | The Economist

July 2, 2021

relevant for indoor air & ventilation

https://www.economist.com/science-and-technology/2021/05/26/improving-ventilation-will-help-curb-sars-cov-2

+ leader
https://www.economist.com/leaders/2021/05/29/it-is-time-to-clean-up-the-air-in-buildings

U.S. Has No Explanation for U.F.O.s, Does Not Rule Out Aliens – The New York Times

July 1, 2021

Found this an amusing & unusual article for @NYTimes. Not sure whether it’s science or fiction – or both. Also, found a related @NewYorker piece useful for background & context
https://www.NewYorker.com/magazine/2021/05/10/how-the-pentagon-started-taking-ufos-seriously

How the Pentagon Started Taking U.F.O.s Seriously
For decades, flying saucers were a punch line. Then the U.S. government got over the taboo.
By Gideon Lewis-Kraus
https://www.NewYorker.com/magazine/2021/05/10/how-the-pentagon-started-taking-ufos-seriously April 30, 2021

https://www.nytimes.com/2021/06/25/us/politics/pentagon-ufo-report.html

The E-Scooters Loved by Silicon Valley Roll Into New York | The New Yorker

July 1, 2021

Wish there was some way of achieving safety with these new scooters.

Thanks for your discussion on this. I don’t understand why, despite all the high-tech mobility we have (e.g. self-driving cars, airbags, drones, &c), that we can’t engineer bikes & scooters to be as safe as cars.

https://www.newyorker.com/magazine/2021/04/26/the-e-scooters-loved-by-silicon-valley-roll-into-new-york

Digital secrets of successful lab management

June 28, 2021

https://www.nature.com/articles/d41586-021-01752-y