https://www.nature.com/articles/d41586-023-00954-w
lecanemab is one of the new drugs
https://www.nature.com/articles/d41586-023-00954-w
lecanemab is one of the new drugs
the authors used deep sequencing of environmental DNA (eDNA) to find human genomic information, which they called human genetic bycatch (HGB). This paper was published in Nature Ecology & Evolution. https://www.nature.com/articles/s41559-023-02056-2
This study was also featured in an article in the New York Times.
https://www.nytimes.com/2023/05/15/science/environmental-dna-ethics-privacy.html
https://www.economist.com/briefing/2023/03/02/a-new-class-of-drugs-for-weight-loss-could-end-obesity
GLP-1 agonists :
wegovy ozempic mounjaro
https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20agonists,and%20contraindications%20for%20these%20drugs. QT:{{”
Mechanism of Action
Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), both incretin hormones inactivated by dipeptidyl peptidase-4 (DPP-4), stimulate insulin secretion after an oral glucose load via the incretin effect.[10][11] In type 2 diabetes, this process can become blunted or even be absent; however, the utilization of pharmacological levels of GLP-1 can revive insulin excretion. The benefits of this form of therapy to treat type 2 diabetes include delayed gastric emptying and inhibiting the production of glucagon from pancreatic alpha cells if blood sugar levels are high.
“}}
https://twit.tv/shows/security-now/episodes/904?autostart=false
Found the whole @LastPass debacle depressing. First, I trusted [Steve Gibson’s] endorsement. Then I trusted it. Now I’m unsure what to do.
Bitwarden? 1password ?
Is it possible to determine how many new sentences & ideas are introduced vs just phrase-scale grammatical and stylistic fixes?
Note that the article didn’t mention the connection between alcohol, stomach acid, GERD & esophageal cancer. Isn’t this another negative of alcohol besides its relationship to DNA damage?
https://www.nytimes.com/2023/01/13/well/mind/alcohol-health-effects.html
20/20 hindsight & 20/200 foresight
https://www.statnews.com/2022/12/27/covid19-pandemic-what-most-surprised-experts/
Great article. Thought the very intentional “wind shaping” was fascinating (e.g. the “blow through” floors at 432 Park). Maybe we’ll see fins next.
QT:{{”
This didn’t seem unrelated to a lawsuit that 432 Park’s condo board has filed against the building’s developer. The plaintiffs claim that the building is riddled with more than 1,500 defects that have led to leaks, cracks, electrical explosions, and elevator shutdowns that trapped people for hours—as well as “horrible and obtrusive noise and vibrations,” including clicks, creaks, and a trash chute that thunders “like a bomb.”
….
diffusing the suction-filled whirlpools that sway a building as wind whips around its sides. You could notch the corners, like on Taipei 101, which resembles a towering stack of gifts. You could twist the building, like the Twizzler-esque Shanghai Tower. You could taper it to look like the tip of a paintbrush, like the Lakhta Center, or cut out sections to let wind blow through it, like the Shanghai World Financial Center, which is nicknamed “The Bottle Opener.” 432 Park’s designers decided to make it more porous: Every 12 stories, there are two “blow through” floors with cutouts for windows, but no glass. “}}
https://www.theatlantic.com/magazine/archive/2023/01/supertall-mega-skyscraper-building-nyc/672228
steinway tower
https://www.dropbox.com/s/soza3usm060fzya/steinway-tower-view.docx?dl=0