TWAS of 229k women identifies new candidate susceptibility genes for breast cancer https://www.Nature.com/articles/s41588-018-0132-x Metascan approach. Derive model for imputing transcriptome from #GTEx & validate against TCGA. Application to BCAC.
Posts Tagged ‘capstone4’
Journal Club by JG
July 27, 2018Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder | Nature Neuroscience
July 27, 2018Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease
Potential role for microglia in Alzheimer’s
June 2, 2018Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline
Nature 03142018 Single cell rnaseq of development of human brain Pfc
March 18, 2018https://www.nature.com/articles/nature25980
A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex
Suijuan Zhong
, Shu Zhang
[…]
Xiaoqun Wang
Nature
doi:10.1038/nature25980
New GWAS SCZ loci (nature genetics 2018)
March 5, 2018Common #schizophrenia alleles are enriched in mutation-intolerant genes & in regions under strong background selection
https://www.nature.com/articles/s41588-018-0059-2 50 novel SCZ loci & 145 loci in total, from #GWAS – associated w/ 33 candidate causal genes
QT:{{”
We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through meta-analysis with existing data we identify 50 novel associated loci and 145 loci in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci.
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Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Nature Genetics (2018)
doi:10.1038/s41588-018-0059-2
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
February 11, 2018http://science.sciencemag.org/content/359/6376/693.full
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perspective
http://science.sciencemag.org/content/359/6376/619.full
Gene Expression Overlaps Among Psychiatric Disorders
Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression.
Neurobiology course
January 20, 2018Understanding the Brain: The Neurobiology of Everyday Life
https://www.coursera.org/learn/neurobiology
Everyday Scientist » deconvoluting deconvolving
January 13, 2018A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in eQTL Studies
January 6, 2018A Bayesian Framework to Account for Complex Non-Genetic Factors in Gene Expression Levels Greatly Increases Power in #eQTL Studies http://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000770 Early discussion & development of PEER factors
