Posts Tagged ‘covid19’

‘Nightmare Scenario’ book excerpt: Inside the extraordinary effort to save Trump from covid-19 – The Wa shington Post

July 17, 2021

antibodies seemed to be very effective

https://www.washingtonpost.com/politics/2021/06/24/nightmare-scenario-book-excerpt/

Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science

July 17, 2021

https://science.sciencemag.org/content/369/6510/1501

BY CHING-LIN HSIEH, JORY A. GOLDSMITH, JEFFREY M. SCHAUB, ANDREA M. DIVENERE, HUNG-CHE KUO, KAMYAB JAVANMARDI, KEVIN C. LE, DANIEL WRAPP, ALISON G. LEE, YUTONG LIU, CHIA-WEI CHOU, PATRICK O. BYRNE, CHRISTY K. HJORTH, NICOLE V. JOHNSON, JOHN LUDES-MEYERS, ANNALEE W. NGUYEN, JUYEON PARK, NIANSHUANG WANG, DZIFA AMENGOR, JASON J. LAVINDER, GREGORY C. IPPOLITO, JENNIFER A. MAYNARD, ILYA J. FINKELSTEIN, JASON S. MCLELLAN

SCIENCE18 SEP 2020 : 1501-1505

The design of stabilizing mutations in the SARS-CoV-2 spike protein allows for high-yield production of a critical vaccine antigen.

In particular,
stabilization is very important for the Moderna vaccine design.

This work builds on :
{{”
Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283.

Structure-based design of a fusion glycoprotein vaccine for
respiratory syncytial virus

Jason S McLellan 1, Man Chen, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W Graepel, Azad Kumar, Syed Moin, Jeffrey C Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S Graham, Peter D Kwong
Affiliations expand

PMID: 24179220 PMCID: PMC4461862 DOI: 10.1126/science.1243283 https://pubmed.ncbi.nlm.nih.gov/24179220/
“}}

The unseen covid-19 risk for unvaccinated people

July 17, 2021

This is the first newspaper article I’ve seen with a *methods* section at the end (which describes how #covid19 death rates could be “adjusted” for vaccine status)

https://www.washingtonpost.com/health/interactive/2021/covid-rates-unvaccinated-people

The unseen covid-19 risk for unvaccinated people

By Dan Keating and Leslie Shapiro

This story was published a few weeks ago but remains incredibly important as the delta variant spreads throughout the U.S.

The country’s declining covid-19 case rates present an unrealistically optimistic perspective for half of the nation — the half that is still not vaccinated.

As more people receive vaccines, covid-19 cases are occurring mostly in the increasingly narrow slice of the unprotected population. So The Washington Post adjusted its case, death and hospitalization rates to account for that — and found that in some places, the virus continues to rage among those who haven’t received a shot. Read more »

Pfizer and Moderna Vaccines Likely to Produce Lasting Immunity, Study Finds – The New York Times

July 1, 2021

https://www.nytimes.com/2021/06/28/health/coronavirus-vaccines-immunity.html

A Pill to Treat Covid-19? The U.S. Is Betting on It. – The New York Times

June 19, 2021

https://www.nytimes.com/2021/06/17/health/covid-pill-antiviral.html?smtyp=cur&smid=tw-nytimes

The Pandemic Changed Our Microbiome, But That’s Okay – The Atlantic

June 6, 2021

https://www.theatlantic.com/health/archive/2021/04/the-pandemic-changed-our-microbiome-but-thats-okay/618760

Why some researchers oppose unrestricted sharing of coronavirus genome data

May 18, 2021

https://www.nature.com/articles/d41586-021-01194-6

Why some researchers oppose unrestricted sharing of coronavirus genome data

May 18, 2021

https://www.nature.com/articles/d41586-021-01194-6

Hundreds of Epidemiologists Expected Mask-Wearing in Public for at Least a Year – The New York Times

May 15, 2021

https://www.nytimes.com/2021/05/13/upshot/epidemiologists-coronavirus-masks.html

Novel vaccines have performed remarkably quickly and well | The Economist

May 11, 2021

https://www.economist.com/technology-quarterly/2021/03/23/novel-vaccines-have-performed-remarkably-quickly-and-well