antibodies seemed to be very effective
https://www.washingtonpost.com/politics/2021/06/24/nightmare-scenario-book-excerpt/
Posts Tagged ‘covid19’
‘Nightmare Scenario’ book excerpt: Inside the extraordinary effort to save Trump from covid-19 – The Wa shington Post
July 17, 2021Structure-based design of prefusion-stabilized SARS-CoV-2 spikes | Science
July 17, 2021https://science.sciencemag.org/content/369/6510/1501
BY CHING-LIN HSIEH, JORY A. GOLDSMITH, JEFFREY M. SCHAUB, ANDREA M. DIVENERE, HUNG-CHE KUO, KAMYAB JAVANMARDI, KEVIN C. LE, DANIEL WRAPP, ALISON G. LEE, YUTONG LIU, CHIA-WEI CHOU, PATRICK O. BYRNE, CHRISTY K. HJORTH, NICOLE V. JOHNSON, JOHN LUDES-MEYERS, ANNALEE W. NGUYEN, JUYEON PARK, NIANSHUANG WANG, DZIFA AMENGOR, JASON J. LAVINDER, GREGORY C. IPPOLITO, JENNIFER A. MAYNARD, ILYA J. FINKELSTEIN, JASON S. MCLELLAN
SCIENCE18 SEP 2020 : 1501-1505
The design of stabilizing mutations in the SARS-CoV-2 spike protein allows for high-yield production of a critical vaccine antigen.
In particular,
stabilization is very important for the Moderna vaccine design.
This work builds on :
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Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283.
Structure-based design of a fusion glycoprotein vaccine for
respiratory syncytial virus
Jason S McLellan 1, Man Chen, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W Graepel, Azad Kumar, Syed Moin, Jeffrey C Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S Graham, Peter D Kwong
Affiliations expand
PMID: 24179220 PMCID: PMC4461862 DOI: 10.1126/science.1243283 https://pubmed.ncbi.nlm.nih.gov/24179220/
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The unseen covid-19 risk for unvaccinated people
July 17, 2021This is the first newspaper article I’ve seen with a *methods* section at the end (which describes how #covid19 death rates could be “adjusted” for vaccine status)
https://www.washingtonpost.com/health/interactive/2021/covid-rates-unvaccinated-people
The unseen covid-19 risk for unvaccinated people
By Dan Keating and Leslie Shapiro
This story was published a few weeks ago but remains incredibly important as the delta variant spreads throughout the U.S.
The country’s declining covid-19 case rates present an unrealistically optimistic perspective for half of the nation — the half that is still not vaccinated.
As more people receive vaccines, covid-19 cases are occurring mostly in the increasingly narrow slice of the unprotected population. So The Washington Post adjusted its case, death and hospitalization rates to account for that — and found that in some places, the virus continues to rage among those who haven’t received a shot. Read more »
