Posts Tagged ‘1000g’

search variants in 10000+ genomes

December 5, 2016

Hum. Longevity

https://search.hli.io/

Human Genome Project: Twenty-five years of big biology

October 17, 2015

HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible

QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.

“}}

Variety of life : Nature News & Comment

October 8, 2015

http://www.nature.com/news/variety-of-life-1.18454

The fine-scale genetic structure of the British population : Nature : Nature Publishing Group

July 11, 2015

The fine-scale genetic structure of the British population
http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html Correlation w. geography, reflecting Anglo-Saxon migration

http://www.nature.com/nature/journal/v519/n7543/full/nature14230.html

No evidence that selection has been less effective at removing deleterious mutations in Europeans than in Africans : Nature Genetics : Nature Publishing Group

January 18, 2015

Removing deleterious mutations in Europeans [v] Africans
http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3186.html Comparing nonsynonymous freq. betw. populations HT @obahcall

The genomic landscape of Neanderthal ancestry in present-day humans : Nature : Nature Publishing Group

November 1, 2014

The genomic landscape of #Neanderthal ancestry in…humans
http://www.nature.com/nature/journal/v507/n7492/full/nature12961.html Regions enriched & depleted in ancient alleles, from 1000G

1004 indiv. => 1000G phase 1

QT:{{”
Here, we have systematically inferred Neandertal haplotypes in the genomes of 1,004 present-day humans. Regions that harbor a high frequency of Neandertal alleles in modern humans are enriched for genes affecting keratin filaments suggesting that Neandertal alleles may have helped modern humans adapt to non-African environments. Neandertal alleles also continue to shape human biology, as we identify multiple Neandertal-derived alleles that confer risk for disease. We also identify regions of millions of base pairs that are nearly devoid of Neandertal ancestry and enriched in genes, implying selection to remove genetic material derived from Neandertals. “}}

Million Veteran Program (MVP)

June 24, 2014

http://www.research.va.gov/MVP/

Principal Investigators :

John Concato, M.D., M.S., M.P.H.
Yale

J. Michael Gaziano, M.D., M.P.H.
Harvard

QT:{{”

It’s Launch Time for the Million Veteran Program…

The VA Office of Research and Development is launching its
unprecedented partnership between VA and Veterans who volunteer to help build one of the largest databases of genetic, military exposure and health information. The Million Veteran Program (MVP) promises to reshape the field of genomics—a sophisticated science poised to revolutionize health care for Veterans and others throughout the U.S. and around the world.

“}}

From Schmidt’s talk: The Million Veteran Program is building a DB of genetic, military exposure & health info
http://www.research.va.gov/MVP #1000gb

amino acid changes in 1000 Genomes Project Thornton Lab

June 23, 2014

1000G v disease variants
http://www.ploscompbiol.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1003382

1000 Genomes Selection Browser 1.0: a genome browser dedicated to signatures of natural selection in modern humans

December 1, 2013

Looks useful!

http://nar.oxfordjournals.org/content/early/2013/11/24/nar.gkt1188

PacBio data for CHM1 genome

October 24, 2013

It look as though the data are now ready for download
http://datasets.pacb.com/2013/Human10x/READS/index.html along with a brief description of the data
http://blog.pacificbiosciences.com/2013/10/data-release-long-read-shotgun.html