Posts Tagged ‘mynotes0mg’

Whole-Genome Sequencing and Social-Network Analysis of a Tuberculosis Outbreak — NEJM

July 22, 2017

WGS & Social-#Network Analysis of a TB Outbreak http://www.NEJM.org/doi/full/10.1056/NEJMoa1003176 Nice tech combo but not sure transmission & phylogeny are consistent

Thoughts on the PsychENCODE workshop & Psychiatric Genomics in the Era of Team Science – 2 recent DC meetings on Neurogenomics

July 10, 2017

https://linkstream2.gerstein.info/tag/i0pec17/

My Notes from BioIT ’17 (i0bioit17, #BioIT17)

June 9, 2017

Links
https://linkstream2.gerstein.info/tag/i0bioit17/

Tweet
https://storify.com/markgerstein/favorite-tweets-from-bioit-17

Talk
http://lectures.gersteinlab.org/summary/Multiscale-Elt-Annotation-n-Var-Prioritization–20170524-i0bioit17/

A Big Bang model of human colorectal tumor growth : Nature Genetics : Nature Research

June 7, 2017

https://www.nature.com/ng/journal/v47/n3/full/ng.3214.html

Big Bang model of…tumor growth, v. slow #evolution under selection https://www.Nature.com/ng/journal/v47/n3/full/ng.3214.html #Cancer is born w/ key mutations all there

Andrea Sottoriva,
Haeyoun Kang,
Zhicheng Ma,
Trevor A Graham,
Matthew P Salomon,
Junsong Zhao,
Paul Marjoram,
Kimberly Siegmund,
Michael F Press,
Darryl Shibata
& Christina Curtis

Nature Genetics 47, 209–216 (2015) doi:10.1038/ng.3214

Common SNPs explain a large proportion of the heritability for human height : Nature Genetics : Nature Research

June 2, 2017

Common SNPs explain a large proportion (45%) of heritability for…height (85%)
http://www.Nature.com/ng/journal/v42/n7/abs/ng.608.html Cf 2010 GWASes could only explain 5%

Jian Yang,
Beben Benyamin,
Brian P McEvoy,
Scott Gordon,
Anjali K Henders,
Dale R Nyholt,
Pamela A Madden,
Andrew C Heath,
Nicholas G Martin,
Grant W Montgomery,
Michael E Goddard
& Peter M Visscher

Nature Genetics 42, 565–569 (2010) doi:10.1038/ng.608

QT:{{”
…conveniently implemented with a mathematically equivalent model that uses the SNPs to calculate the genomic relationship between pairs of subjects). Using this approach, we estimated the proportion of pheno­typic variance explained by the SNPs as 0.45 (s.e. = 0.08, Table 1), a nearly tenfold increase relative to the 5% explained by published and validated individual SNPs
“}}

Common SNPs explain a large proportion of the heritability for human height : Nature Genetics : Nature Research

June 1, 2017

http://www.nature.com/ng/journal/v42/n7/abs/ng.608.html

Common SNPs explain a large proportion of the heritability for human height

Jian Yang,
Beben Benyamin,
Brian P McEvoy,
Scott Gordon,
Anjali K Henders,
Dale R Nyholt,
Pamela A Madden,
Andrew C Heath,
Nicholas G Martin,
Grant W Montgomery,
Michael E Goddard
& Peter M Visscher

Nature Genetics 42, 565–569 (2010) doi:10.1038/ng.608

QT:{{"
…conveniently implemented with a mathematically equivalent model
that uses the SNPs to calculate the genomic relationship between
pairs of subjects). Using this approach, we estimated the proportion
of pheno­typic variance explained by the SNPs as 0.45 (s.e. = 0.08,
Table 1), a nearly tenfold increase relative to the 5% explained by
published and validated individual SNPs
"}}

Common SNPs explain a large proportion (45%) of heritability for…height (80%) http://www.Nature.com/ng/journal/v42/n7/abs/ng.608.html Vs ’10 GWAS SNPs could only expl. 5%

Thoughts on last week’s conferences GP-Write & BoG ’17

May 15, 2017

TWEETS

https://storify.com/markgerstein/favorite-tweets-from-bog-17-gp-write-ib.html

TAGGED ITEMS

https://linkstream2.gerstein.info/tag/i0gpwrite/

SLIDES

http://lectures.gersteinlab.org/summary/Scaling-Computation-to-Keep-Pace-w-Data-Gen–20170510-i0gpwrite/

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors : Nature Genetics : Nature Research

May 6, 2017

http://www.nature.com/ng/journal/v49/n5/full/ng.3818.html

Ref component analysis..of transcriptomes, by @Robson_Paul &co http://www.Nature.com/ng/journal/v49/n5/full/ng.3818.html Clustering similarity of samples to tissue references

Aging increases cell-to-cell transcriptional variability upon immune stimulation | Science

April 21, 2017

#Aging increases cell-to-cell transcriptional variability upon immune stimulation, but just for 225 up-reg. genes http://science.ScienceMag.org/content/355/6332/1433

Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression: Cell

April 16, 2017

"Impacts of Neanderthal-Introgressed Sequences on the Landscape of Human Gene Expression"

(http://www.sciencedirect.com/science/article/pii/S0092867417301289)

#Neanderthal-Introgressed Sequences [&]…Gene Expression http://www.Cell.com/cell/abstract/S0092-8674(17)30128-9?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867417301289%3Fshowall%3Dtrue ASE for Hn SNPs shows lower #brain expression vs reference