Tom Kean, New Jersey Congressman, Says Depression Led to Long Absence – The New York Times
https://www.nytimes.com/2026/06/30/us/politics/tom-kean-return-depression.html
Posts Tagged ‘x57s’
Tom Kean, New Jersey Congressman, Says Depression Led to Long Absence – The New York Times
July 1, 2026NYTimes.com: My Quest to Solve Bitcoin’s Great Mystery
April 11, 2026Carreyrou, J., & Freedman, D. (2026, April 8). Who is Satoshi Nakamoto? My quest to unmask Bitcoin’s creator. The New York Times.
https://www.nytimes.com/2026/04/08/business/bitcoin-satoshi-nakamoto-identity-adam-back.htm
My Quest to Solve Bitcoin’s Great Mystery
Bitcoin’s creator has hidden behind the pseudonym Satoshi Nakamoto for 17 years. But a trail of clues buried deep in crypto lore led to a 55-year-old computer scientist named Adam Back.
Oral Semaglutide: How It Works, Side Effects, & More | Ro
March 29, 2026https://ro.co/weight-loss/oral-semaglutide/
a new pill
Huntington disease – PubMed
March 29, 2026https://pubmed.ncbi.nlm.nih.gov/27188817/
ASO v RNAi v siRNA
QT:{{”
how a specific toxic conformation might be favoured
within the expanded polyQ of monomeric HTT exon1
is unclear37,47. More-complex conformational effects in
monomeric HTT exon1 linked to polyQ repeat length
are formally possible but challenging to establish37,49. By
contrast, the widely reported ability of HTT exon1 to
readily form a variety of aggregated structures presents
an array of plausible candidates that might mediate toxicity (see below)37. This aggregation links Huntington
disease to other neurodegenerative diseases that feature
a protein aggregation component, including Alzheimer
disease, Parkinson disease, amyotrophic lateral sclerosis
and spongiform encephalopathies.
…
bind to HTT mRNA selectively and target it for degradation
by cellular mechanisms. When the agent is a short
interfering RNA (siRNA) or microRNA, the HTT
mRNA is degraded by cytoplasmic RNA-induced silencing
complex (RISC) — a process known as RNA interference
(RNAi). Alternatively, a single-stranded modified
DNA molecule or antisense oligonucleotide (ASO) can
be used to direct the transcript for degradation by
nuclear ribonuclease H.
“}}
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., Nance, M., Ross, C. A., Scahill, R. I., Wetzel, R., Wild, E. J., & Tabrizi, S. J. (2015). Huntington disease. Nature Reviews Disease Primers, 1(1), 15005.
https://doi.org/10.1038/nrdp.2015.5
from G search {{
”
Yes, amyloid fibrils in Huntington’s disease (HD) contain a specific protein—the mutated huntingtin (Htt) protein. These fibrils are formed specifically from the N-terminal exon 1 fragment of the mutant protein, which contains an expanded polyglutamine (polyQ) tract that forms the amyloid core.
….
Although they contain the mutant protein, the amyloid fibrils in HD are distinct from those in Alzheimer’s (A
) or Parkinson’s (
-synuclein) diseases.
”
}}
Likelihood function – Wikipedia
October 7, 2025https://en.wikipedia.org/wiki/Likelihood_function
QT:{{"In other words, when 
"}}
Visualizing Quantum Logic Gates – Bloch Sphere | Quantum Untangled
May 17, 2025Doesn’t show how to combine two gates or make an AND
https://medium.com/quantum-untangled/visualizing-quantum-logic-gates-part-1-515bb7b58916
Shetty, A. (2021, December 30). Visualizing Quantum Logic Gates – Bloch Sphere | Quantum Untangled. Medium.
https://medium.com/quantum-untangled/visualizing-quantum-logic-gates-part-1-515bb7b58916
1906.02691 An Introduction to Variational Autoencoders
March 2, 2025Has detailed setup for ELBO
https://arxiv.org/abs/1906.02691
Kingma, D. P., & Welling, M. (2019). An introduction to variational autoencoders. Foundations and Trends® in Machine Learning, 12(4), 307–392. https://doi.org/10.1561/2200000056
linkstream2 microblog 