Posts Tagged ‘psychencode’

Potential role for microglia in Alzheimer’s

June 2, 2018

http://www.sciencemag.org/news/2016/03/alzheimer-s-may-be-caused-haywire-immune-system-eating-brain-connections

Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline

Nature 03142018 Single cell rnaseq of development of human brain Pfc

March 18, 2018

https://www.nature.com/articles/nature25980

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

Suijuan Zhong
, Shu Zhang
[…]
Xiaoqun Wang
Nature
doi:10.1038/nature25980

New GWAS SCZ loci (nature genetics 2018)

March 5, 2018

Common #schizophrenia alleles are enriched in mutation-intolerant genes & in regions under strong background selection
https://www.nature.com/articles/s41588-018-0059-2 50 novel SCZ loci & 145 loci in total, from #GWAS – associated w/ 33 candidate causal genes

QT:{{”
We report a new genome-wide association study of schizophrenia (11,260 cases and 24,542 controls), and through meta-analysis with existing data we identify 50 novel associated loci and 145 loci in total. Through integrating genomic fine-mapping with brain expression and chromosome conformation data, we identify candidate causal genes within 33 loci.
“}}

Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection
Nature Genetics (2018)
doi:10.1038/s41588-018-0059-2

The Brain That Couldn’t Remember – The New York Times

March 5, 2018

The #Brain That Couldn’t Remember
http://www.NYTimes.com/2016/08/07/magazine/the-brain-that-couldnt-remember.html Fight over the ownership of HM’s highlights issues in consent HT @FearLoathingBTX

Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap

February 11, 2018

http://science.sciencemag.org/content/359/6376/693.full
+
perspective
http://science.sciencemag.org/content/359/6376/619.full

Gene Expression Overlaps Among Psychiatric Disorders

Transcriptional profiling of post-mortem human brains reveals commonalities in the genes over- and under-expressed in schizophrenia, bipolar disorder, autism, and major depression.

Neurobiology course

January 20, 2018

Understanding the Brain: The Neurobiology of Everyday Life
https://www.coursera.org/learn/neurobiology

A Code for Autism | Proto Magazine

December 16, 2017

http://protomag.com/articles/code-autism

GTEx paper

October 22, 2017

Paper about what will be on eGTEx project:
https://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3969.html

Gtex Nature
https://www.nature.com/nature/journal/v550/n7675/full/nature24267.html https://www.nature.com/nature/journal/v550/n7675/full/nature24265.html https://www.nature.com/nature/journal/v550/n7675/full/nature24041.html http://www.nature.com/nature/journal/v550/n7675/full/nature24277.html

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls | bioRxiv

July 31, 2017

Eval of Chromatin Accessibility [via #ATACSeq] in DLPFC of SCZ Cases/Ctrls, by @JulienBryois et al.
http://www.BiorXiv.org/content/early/2017/05/25/141986 List of cQTLs

George Church ascribes his visionary ideas to narcolepsy

July 18, 2017

.@GeoChurch ascribes his…ideas to narcolepsy
https://www.StatNews.com/2017/06/08/george-church-narcolepsy Advocates more neurodiversity, ie those w. ASD, OCD, ADD + narcolepsy

QT:{{”
“His condition has persuaded Church of the benefits of, even the need for, neurodiversity, meaning brains that work differently from most others. The world needs people with high-functioning autism and obsessive-compulsive disorder and attention deficit disorder and, yes, narcolepsy, he has come to believe.”
“}}