Posts Tagged ‘psychencode’

Rare coding variants in ten genes confer substantial risk for schizophrenia | Nature

April 23, 2022


January 29, 2022

eQTLs paper is out in Nature Genetics:

Zeng, B., Bendl, J., Kosoy, R. et al. [Panos R] Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits. Nat Genet (2022).

Single cell estimation from bulk data

April 12, 2020

Accurate estimation of cell composition in bulk expression through robust integration of single-cell information

Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin doi:

Quantifying the tradeoff between sequencing depth and cell number in single-cell RNA-seq

November 2, 2019

Second fetal brain article…splciing and expression QTL and integration with single cell with WGCNA networks

October 29, 2019

Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind,

Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms,


Volume 179, Issue 3,
Pages 750-771.e22,
ISSN 0092-8674,

Genomic Data from 2,000 Brains Provides Roots of Schizophrenia, Autism – Market Research Chronicle

September 14, 2019

GWAS ATLAS resource

August 24, 2019

A global overview of pleiotropy and genetic architecture in complex traits

Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Christiaan de Leeuw, Tinca J. C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale & Danielle Posthuma

Single Cell Resource for Mouse

August 2, 2019


Tabula Muris is a compendium of single cell transcriptome data from the model organism Mus musculus, containing nearly 100,000 cells from 20 organs and tissues. The data allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as immune cells from distinct anatomical locations. They also allow for a comparison of two distinct technical approaches: “}}

SHANK3 | Spectrum | Autism Research News

July 19, 2019

From Zhu et al. Science (’18)
Further analysis revealed that the ASD-associated genes SHANK2 and SHANK3, which encode synaptic scaffolding proteins at the postsynaptic density of excitatory glutamatergic synapses, exhibited earlier expression in the macaque NCX and other brain regions relative to humans (Fig. 7B).

Alzheimer’s disease risk genes and mechanisms of disease pathogenesis

June 21, 2019
Some related to mechanism