Posts Tagged ‘psychencode’

Evaluation Of Chromatin Accessibility In Prefrontal Cortex Of Schizophrenia Cases And Controls | bioRxiv

July 31, 2017

Eval of Chromatin Accessibility [via #ATACSeq] in DLPFC of SCZ Cases/Ctrls, by @JulienBryois et al. List of cQTLs


George Church ascribes his visionary ideas to narcolepsy

July 18, 2017

.@GeoChurch ascribes his…ideas to narcolepsy Advocates more neurodiversity, ie those w. ASD, OCD, ADD + narcolepsy

“His condition has persuaded Church of the benefits of, even the need for, neurodiversity, meaning brains that work differently from most others. The world needs people with high-functioning autism and obsessive-compulsive disorder and attention deficit disorder and, yes, narcolepsy, he has come to believe.”

Thoughts on the PsychENCODE workshop & Psychiatric Genomics in the Era of Team Science – 2 recent DC meetings on Neurogenomics

July 10, 2017

Single Cell Analysis paper

June 30, 2017

16 Neuronal subtypes & [inter-regional] diversity revealed by [#singlecell]-nucleus RNAseq of…the brain

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.

A survey of human brain transcriptome diversity at the single cell level

June 27, 2017

Brain #transcriptome diversity at the single cell level Has useful gene-exp. profiles of specific neural cell types

has profiles for 185 biomarker genes for 6 cell types

US mental-health agency’s push for basic research has slashed support for clinical trials

June 19, 2017


“This shift has been having profound impacts on mental-health research in the United States, but the magnitude of the transformation is only now coming to light. An analysis by Nature suggests that the number of clinical trials funded by the NIMH dropped by 45% between 2009 and 2015 (see ‘’). This coincides with the agency’s launch, in 2011, of the Research Domain Criteria (RDoC) — a framework for research on the mechanisms of mental illness. The NIMH’s roll-out of RDoC included asking researchers to focus more on the biological bases of behaviour — such as brain circuitry and genetics — than on the broader symptoms that clinicians typically use to define and classify mental illness.

The NIMH’s embrace of fundamental research has infuriated many clinical researchers, who see it as an attempt to invalidate their methods — and say that there is scant evidence to support the idea that using RDoC will lead to greater insight or better treatments for mental illness.”

US mental-health agency’s push for basic research has slashed support for clinical trials

A comprehensive transcriptional map of primate brain development

June 19, 2017

A…transcriptional map of primate (macaque) #brain development Gene expression changes more rapidly before birth
Nature (2016) doi:10.1038/nature18637

Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network | Science

May 15, 2017

The #Brain #Somatic Mosaicism Network Long lifespan of neurons accentuates impact of individual somatic mutations

Neuropsychiatric disorders have a complex genetic architecture. Human genetic population-based studies have identified numerous heritable sequence and structural genomic variants associated with
susceptibility to neuropsychiatric disease. However, these germline variants do not fully account for disease risk. During brain development, progenitor cells undergo billions of cell divisions to generate the ~80 billion neurons in the brain. The failure to accurately repair DNA damage arising during replication,
transcription, and cellular metabolism amid this dramatic cellular expansion can lead to somatic mutations. Somatic mutations that alter subsets of neuronal transcriptomes and proteomes can, in turn, affect cell proliferation and survival and lead to neurodevelopmental disorders. The long life span of individual neurons and the direct relationship between neural circuits and behavior suggest that somatic mutations in small populations of neurons can significantly affect individual neurodevelopment. The Brain Somatic Mosaicism Network has been founded to study somatic mosaicism both in neurotypical human brains and in the context of complex neuropsychiatric disorders.” “}}

Mirror neuron – Wikipedia

May 8, 2017

Spindle neuron – Wikipedia

May 8, 2017


Spindle neurons, also called von Economo neurons (VENs), are a specific class of neurons that are characterized by a large
spindle-shaped soma (or body), gradually tapering into a single apical axon in one direction, with only a single dendrite facing opposite. Other neurons tend to have many dendrites, and the polar-shaped morphology of spindle neurons is unique. A neuron’s dendrites receive signals, and its axon sends them.

Spindle neurons are found in two very restricted regions in the brains of hominids—the family of species comprising humans and other great apes—the anterior cingulate cortex (ACC) and the fronto-insular cortex (FI). Recently they have been discovered in the dorsolateral prefrontal cortex of humans.[1] Spindle cells are also found in the brains of the humpback whales, fin whales, killer whales, sperm whales,[2][3] bottlenose dolphin, Risso’s dolphin, beluga whales,[4] African and Asian elephants,[5] and to a lesser extent in macaque monkeys[6] and raccoons.[7] The appearance of spindle neurons in distantly related clades suggests that they represent convergent evolution, specifically an adaptation to larger brains.