Posts Tagged ‘psychencode’
science
January 29, 2022eQTLs paper is out in Nature Genetics:
Zeng, B., Bendl, J., Kosoy, R. et al. [Panos R] Multi-ancestry eQTL meta-analysis of human brain identifies candidate causal variants for brain-related traits. Nat Genet (2022).
https://doi.org/10.1038/s41588-021-00987-9
Single cell estimation from bulk data
April 12, 2020Accurate estimation of cell composition in bulk expression through robust integration of single-cell information
Brandon Jew, Marcus Alvarez, Elior Rahmani, Zong Miao, Arthur Ko, Jae Hoon Sul, Kirsi H. Pietiläinen, Päivi Pajukanta, Eran Halperin doi:
Quantifying the tradeoff between sequencing depth and cell number in single-cell RNA-seq
November 2, 2019Second fetal brain article…splciing and expression QTL and integration with single cell with WGCNA networks
October 29, 2019https://www.sciencedirect.com/science/article/pii/S0092867419310724?dgcid=author
Rebecca L. Walker, Gokul Ramaswami, Christopher Hartl, Nicholas Mancuso, Michael J. Gandal, Luis de la Torre-Ubieta, Bogdan Pasaniuc, Jason L. Stein, Daniel H. Geschwind,
Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms,
Cell,
Volume 179, Issue 3,
2019,
Pages 750-771.e22,
ISSN 0092-8674,
https://doi.org/10.1016/j.cell.2019.09.021
Genomic Data from 2,000 Brains Provides Roots of Schizophrenia, Autism – Market Research Chronicle
September 14, 2019GWAS ATLAS resource
August 24, 2019A global overview of pleiotropy and genetic architecture in complex traits
Kyoko Watanabe, Sven Stringer, Oleksandr Frei, Maša Umićević Mirkov, Christiaan de Leeuw, Tinca J. C. Polderman, Sophie van der Sluis, Ole A. Andreassen, Benjamin M. Neale & Danielle Posthuma
Single Cell Resource for Mouse
August 2, 2019QT:{{”
Tabula Muris is a compendium of single cell transcriptome data from the model organism Mus musculus, containing nearly 100,000 cells from 20 organs and tissues. The data allow for direct and controlled comparison of gene expression in cell types shared between tissues, such as immune cells from distinct anatomical locations. They also allow for a comparison of two distinct technical approaches: “}}
SHANK3 | Spectrum | Autism Research News
July 19, 2019https://www.spectrumnews.org/wiki/shank3/
From Zhu et al. Science (’18)
QT:{{”
Further analysis revealed that the ASD-associated genes SHANK2 and SHANK3, which encode synaptic scaffolding proteins at the postsynaptic density of excitatory glutamatergic synapses, exhibited earlier expression in the macaque NCX and other brain regions relative to humans (Fig. 7B).
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Alzheimer’s disease risk genes and mechanisms of disease pathogenesis
June 21, 2019https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4234692/
Some related to mechanism
linkstream2 microblog 