Posts Tagged ‘cornerstone’

serotonin & depression

August 28, 2022

https://www.nature.com/articles/s41380-022-01661-0

QT:{{”
For decades, doctors believed ssris operated by boosting levels of serotonin, a chemical which carries signals between neurons in the brain. This supposition was based on the hypothesis that a lack of serotonin causes depression. But a growing number of investigations suggest that theory does not hold water—a conclusion hammered home by a round-up of reviews of such work just published in Molecular Psychiatry.
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https://www.economist.com/science-and-technology/2022/07/20/a-popular-medical-explanation-for-depression-is-rebuffed

SLC6A4 Gene – GeneCards | SC6A4 Protein | SC6A4 Antibody

August 1, 2022

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4

QT:{{”
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
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famous serotonin re-update transporter

FYI aging and chrom

May 26, 2022

https://www.medrxiv.org/content/10.1101/2022.01.18.22269350v3

Brain tissue expression of SST – Summary – The Human Protein Atlas

May 22, 2022

https://www.proteinatlas.org/ENSG00000157005-SST/brain

gene & also cell type

Single cell type – PVALB – The Human Protein Atlas

May 22, 2022

https://www.proteinatlas.org/ENSG00000100362-PVALB/single+cell+type

neuron

ScEQTL

May 12, 2022

https://www.nature.com/articles/s41586-022-04713-1

Published: 11 May 2022
Single-cell eQTL models reveal dynamic T cell state dependence of disease loci Aparna Nathan, Samira Asgari, Kazuyoshi Ishigaki, Cristian Valencia, Tiffany Amariuta, Yang Luo, Jessica I. Beynor, Yuriy Baglaenko, Sara Suliman, Alkes L. Price, Leonid Lecca, Megan B. Murray, D. Branch Moody & Soumya Raychaudhuri
Nature (2022)

NRGN Gene – GeneCards | NEUG Protein | NEUG Antibody

May 9, 2022

https://www.genecards.org/cgi-bin/carddisp.pl?gene=NRGN

Aging related gene in capstone4

Statistical and machine learning methods for spatially resolved transcriptomics data analysis | Genome Biology | Full Text

April 29, 2022

https://genomebiology.biomedcentral.com/articles/10.1186/s13059-022-02653-7

Rare coding variants in ten genes confer substantial risk for schizophrenia | Nature

April 23, 2022

https://www.nature.com/articles/s41586-022-04556-w

Mapping genomic loci implicates genes and synaptic biology in schizophrenia | Nature

April 23, 2022

https://www.nature.com/articles/s41586-022-04434-5