https://www.nature.com/articles/d41586-026-00911-3
NEWS AND VIEWS
15 April 2026
How effective is the personalized off-label use of targeted cancer treatment If general cancer treatment fails, a tumour-type-specific therapy might be tried for other cancers with genetic changes in the targeted pathway. How well does this work?
By Funda Meric-Bernstam
https://www.nature.com/articles/d41586-025-00088-1
Özel, M. N., & Desplan, C. (2025). Does a cell’s gene expression always reflect its function? Nature, 638(8052), 899–900.
https://doi.org/10.1038/d41586-025-00088-1
https://www.nature.com/articles/d41586-025-02252-z
Russo, L. (2025). AI learns from nature to design super-adhesive gels that work underwater. Nature, 644(8075), 47–48.
https://doi.org/10.1038/d41586-025-02252-z
https://www.nature.com/articles/s41586-025-09702-8
Demontis, D., Duan, J., Hsu, Y. H., Pintacuda, G., Grove, J., Nielsen, T. T., Thirstrup, J., Martorana, M., Botts, T., Satterstrom, F. K., Bybjerg-Grauholm, J., Tsai, J. H. Y., Glerup, S., Hoogman, M., Buitelaar, J., Klein, M., Ziegler, G. C., Jacob, C., Grimm, O., . . . Børglum, A. D. (2025). Rare genetic variants confer a high risk of ADHD and implicate neuronal biology. Nature.
https://doi.org/10.1038/s41586-025-09702-8
QT:{{”
Common genetic variants associated with the disorder have been identified12,13, but the role of rare variants in ADHD is mostly unknown. Here, by analysing rare coding variants in exome-sequencing data from 8,895 individuals with ADHD and 53,780 control individuals, we identify three genes (MAP1A, ANO8 and ANK2; P < 3.07 × 10−6; odds ratios 5.55–15.13) that are implicated in ADHD.
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https://www.cell.com/current-biology/fulltext/S0960-9822(25)00583-4
Soroka, T., Ravia, A., Snitz, K., Honigstein, D., Weissbrod, A., Gorodisky, L., Weiss, T., Perl, O., & Sobel, N. (2025). Humans have nasal respiratory fingerprints. Current Biology.
https://doi.org/10.1016/j.cub.2025.05.008
https://www.nature.com/articles/d41586-019-03061-x
Levy, A. (2019). How evolution builds genes from scratch. Nature, 574(7778), 314–316. https://doi.org/10.1038/d41586-019-03061-x
How evolution builds genes from scratch
Scientists long assumed that new genes appear when evolution tinkers with old ones. It turns out that natural selection is much more creative.
https://www.nature.com/articles/d41586-024-03866-5
QT:{{”
One particular gut microbe is quite the coffee fiend. Lawsonibacter asaccharolyticus was up to eight times more abundant in coffee drinkers than in non-drinkers. In a culture dish, the bacteria grew faster when fed coffee of any kind — brewed or instant, caffeinated or decaffeinated — than when fed no coffee.
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