Posts Tagged ‘singlecell’

Single-cell genomics of autism

May 18, 2019

Human Cell Atlas Method Development Community timeline

April 6, 2019


March 2, 2019

A lineage-resolved molecular atlas of C elegans embryogenesis at #singlecell resolution, w/ @JIsaacMurray, @JunhyongKim, @ColeTrapnell & B Waterston Compares the known cell lineage of the worm to trees based on UMAP cell-type clusters. Remarkable agreement

A single-cell molecular map of mouse gastrulation and early organogenesis | Nature

February 28, 2019

The single-cell transcriptional landscape of mammalian organogenesis

February 28, 2019

Using single-cell combinatorial indexing, we profiled the
transcriptomes of around 2 million cells derived from 61 embryos staged between 9.5 and 13.5 days of gestation, in a single experiment.

Everyday Scientist ยป deconvoluting deconvolving

January 13, 2018

A survey of human brain transcriptome diversity at the single cell level

June 27, 2017

Brain #transcriptome diversity at the single cell level Has useful gene-exp. profiles of specific neural cell types

has profiles for 185 biomarker genes for 6 cell types

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors : Nature Genetics : Nature Research

May 6, 2017

Ref component analysis..of transcriptomes, by @Robson_Paul &co Clustering similarity of samples to tissue references

Aging increases cell-to-cell transcriptional variability upon immune stimulation | Science

April 21, 2017

#Aging increases cell-to-cell transcriptional variability upon immune stimulation, but just for 225 up-reg. genes

Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes

July 2, 2016

#SingleCell Coexpression…Reveals Distinct Func. Modules [v clustering bulk RNAseq]… & Clinical Outcomes [in GBM]

We found that the co-expressed genes observed in single cells and bulk tumors have little overlap and show distinct characteristics. The co-expressed genes identified in bulk tumors tend to have similar biological functions, and are enriched for intrachromosomal
interactions with synchronized promoter activity. In contrast, single-cell co-expressed genes are enriched for known protein-protein interactions, and are regulated through interchromosomal interactions. “}}