Posts Tagged ‘keyabbrev’

Conquering Alzheimer’s: a look at the therapies of the future

May 29, 2023

https://www.nature.com/articles/d41586-023-00954-w

lecanemab is one of the new drugs

A new class of drugs for weight loss could end obesity | The Economist

April 28, 2023

https://www.economist.com/briefing/2023/03/02/a-new-class-of-drugs-for-weight-loss-could-end-obesity
GLP-1 agonists :
wegovy ozempic mounjaro

https://www.ncbi.nlm.nih.gov/books/NBK551568/#:~:text=Glucagon%2Dlike%20peptide%2D1%20agonists,and%20contraindications%20for%20these%20drugs. QT:{{”
Mechanism of Action
Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), both incretin hormones inactivated by dipeptidyl peptidase-4 (DPP-4), stimulate insulin secretion after an oral glucose load via the incretin effect.[10][11] In type 2 diabetes, this process can become blunted or even be absent; however, the utilization of pharmacological levels of GLP-1 can revive insulin excretion. The benefits of this form of therapy to treat type 2 diabetes include delayed gastric emptying and inhibiting the production of glucagon from pancreatic alpha cells if blood sugar levels are high.
“}}

A new class of drugs for weight loss could end obesity | The Economist

April 28, 2023

https://www.economist.com/briefing/2023/03/02/a-new-class-of-drugs-for-weight-loss-could-end-obesity
GLP-1 agonists :
wegovy ozempic mounjaro

QT:{{”
Mechanism of Action
Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide (GIP), both incretin hormones inactivated by dipeptidyl peptidase-4 (DPP-4), stimulate insulin secretion after an oral glucose load via the incretin effect.[10][11] In type 2 diabetes, this process can become blunted or even be absent; however, the utilization of pharmacological levels of GLP-1 can revive insulin excretion. The benefits of this form of therapy to treat type 2 diabetes include delayed gastric emptying and inhibiting the production of glucagon from pancreatic alpha cells if blood sugar levels are high.
“}}

Happy Birthday, Omicron – The New York Times

December 3, 2022

QT:{{”
But rather than a single lineage, it has exploded into hundreds, each with resistance to our immune defenses and its own alphanumeric name, like XBB, BQ.1.1 and CH.1.
“}}

https://www.nytimes.com/2022/11/26/science/omicron-birthday-variant-evolution.html

AT4G25530(FWA)

September 24, 2022

https://www.arabidopsis.org/servlets/TairObject?type=locus&name=At4g25530

Epigenetic inheritance at the agouti locus in the mouse | Nature Genetics

September 24, 2022

https://www.nature.com/articles/ng1199_314

Lowe’s Delivery Near Me | Instacart

September 3, 2022

https://www.instacart.com/store/lowes-home-improvement/search/weatherstripping?elevated_product_id=22754415
same day delivery
V25W, R516,R516W,M13WH,EF41,AC43

SLC6A4 Gene – GeneCards | SC6A4 Protein | SC6A4 Antibody

August 1, 2022

https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4

QT:{{”
This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
“}}
famous serotonin re-update transporter

A tale of two antiviral targets — and the COVID-19 drugs that bind them

July 30, 2022

Found it interesting that while Paxlovid has had greater success against #COVID19, Molnupiravir (& Remdesivir) might have more promise for future pandemics

QT:{{”
Not all RdRp inhibitors work the same way. In most cases, including with remdesivir, viruses incorporate the drug into the elongating RNA, and this brings the elongation process to a halt. Molnupiravir’s mechanism is different: elongation doesn’t stop when the enzyme incorporates the drug into viral RNA. Instead, the virus reuses molnupiravir-containing RNAs as template strands, and incorporates the wrong bases into new viral RNA when it re-encounters molnupiravir. Mutations accumulate over cycles, leading to ‘error catastrophe’ and viral death.
“}}

https://www.nature.com/articles/d41573-021-00202-8

The first underground warren for disposing of spent nuclear fuel | The Economist

July 14, 2022

https://www.economist.com/science-and-technology/2022/06/22/the-first-underground-warren-for-disposing-of-spent-nuclear-fuel

Onkalo