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But rather than a single lineage, it has exploded into hundreds, each with resistance to our immune defenses and its own alphanumeric name, like XBB, BQ.1.1 and CH.1.
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https://www.nytimes.com/2022/11/26/science/omicron-birthday-variant-evolution.html
https://www.instacart.com/store/lowes-home-improvement/search/weatherstripping?elevated_product_id=22754415
same day delivery
V25W, R516,R516W,M13WH,EF41,AC43
https://www.genecards.org/cgi-bin/carddisp.pl?gene=SLC6A4
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This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
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famous serotonin re-update transporter
Found it interesting that while Paxlovid has had greater success against #COVID19, Molnupiravir (& Remdesivir) might have more promise for future pandemics
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Not all RdRp inhibitors work the same way. In most cases, including with remdesivir, viruses incorporate the drug into the elongating RNA, and this brings the elongation process to a halt. Molnupiravir’s mechanism is different: elongation doesn’t stop when the enzyme incorporates the drug into viral RNA. Instead, the virus reuses molnupiravir-containing RNAs as template strands, and incorporates the wrong bases into new viral RNA when it re-encounters molnupiravir. Mutations accumulate over cycles, leading to ‘error catastrophe’ and viral death.
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Interesting how an ecosystem disruptor now becomes an essential keystone.
https://www.newscientist.com/article/mg25333780-800-rabbits-face-a-fresh-onslaught-akin-to-myxomatosis-can-they-survive/
Oryctolagus cuniculus
creb1 & creb2 (activator v repressor)
linkstream2 microblog 