Posts Tagged ‘quote’

iPhone Notebook export for A Thousand Brains: A New Theory of Intelligence

October 18, 2021

https://www.goodreads.com/notes/54752471-a-thousand-brains/114528832-mark-gerstein?ref=h_cr

Computational scientists look for lessons learned from the COVID-19 pandemic

September 19, 2021

https://cen.acs.org/physical-chemistry/computational-chemistry/Computational-scientists-look-lessons-learned/99/i28
QT:{{”
One computational achievement stands out from the rest—models of the virus’s proteins. In February 2020, with the virus spreading rapidly around the world, structural biologist Jason S. McLellan at the University of Texas at Austin and colleagues at the National Institutes of Health used cryo-electron microscopy (cryo-EM) to make detailed structures of SARS-CoV-2’s spike protein. The virus uses the spike protein to attach to and enter human cells. This protein is a major target for drugs and vaccines. Within weeks of McLellan’s team publishing the cryo-EM data, Rommie Amaro’s group at the University of California San Diego used those structures to create the first computer models of the protein using artificial intelligence and other computational techniques.

In the months that followed, the group used those tools to make more-highly-detailed models of the spike protein. For example, the researchers modeled what the sugars that dot the protein’s surface look like—a feature that cryo-EM can’t capture but that is important for understanding how antibodies or drugs may interact with the protein. Their simulations also showed how the protein’s shape changes to reveal its receptor-binding domain, a region that scientists want to target with therapeutics. The work won Amaro’s group a special kind of Gordon Bell Prize, one of the most prestigious awards in
supercomputing.
“}}

https://amarolab.ucsd.edu/

10+ Best “A Beautiful Mind” Movie Quotes | Quote Catalog

September 18, 2021

QT:{{”
“George Mackey: How could you, a mathematician, a man devoted to reason and logical proof, how could you believe that extraterrestrials are sending you messages?

Steve Nash: Because the ideas I had about supernatural beings came to me the same way that my mathematical ideas did. So I took them seriously.”
— George Mackey, Steve Nash, A Beautiful Mind
“}}

https://quotecatalog.com/quotes/movies/a-beautiful-mind

iPad Notebook export for The Disordered Mind: What Unusual Brains Tell Us About Ourselves

September 18, 2021

https://www.goodreads.com/notes/38221222-the-disordered-mind/114528832-mark-gerstein?ref=h_cr

Why Anti-Covid Plastic Barriers May Make Things Worse – The New York Times

August 29, 2021

QT:{{”
To understand why screens often have little effect on protecting people from aerosol particles, it helps to think about exhaled breath like a plume of cigarette smoke, Dr. Marr said.
“One way to think about plastic barriers is that they are good for blocking things like spitballs but ineffective for things like cigarette smoke,” Dr. Marr said. “The smoke simply drifts around them, so they will give the person on the other side a little more time before being exposed to the smoke. Meanwhile, people on the same side with the smoker will be exposed to more smoke, since the barriers trap it on that side until it has a chance to mix throughout the space.” “}}

Another useful fact connected to this thread is that secondhand cigarette smoke is a good indicator of aerosol behavior
https://www.nhregister.com/opinion/article/Opinion-What-secondhand-smoke-tells-us-about-the-15794467.php viz: https://twitter.com/MarkGerstein/status/1430324404752318464

https://www.nytimes.com/2021/08/19/well/live/coronavirus-restaurants-classrooms-salons.html

The long goodbye to covid-19 | The Economist

August 14, 2021

https://www.economist.com/leaders/2021/07/03/the-long-goodbye-to-covid-19

QT:{{
“In Britain, where Delta is dominant, the fatality rate if you become infected is now about 0.1%, similar to seasonal flu: a danger, but a manageable one.”
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Liked the “shifts”!
Also, thought the following quote was quite interesting: “In Britain, where Delta is dominant, the fatality rate if you become infected is now about 0.1%, similar to seasonal flu.” So if we get covid & flu shots each year, both diseases will become comparable, in a sense? Mark Gerstein

A growing number of governments hope to clone America’s DARPA | The Economist

August 10, 2021

https://www.economist.com/science-and-technology/2021/06/03/a-growing-number-of-governments-hope-to-clone-americas-darpa

QT:{{”

Using messenger rna to make vaccines was an unproven idea. But if it worked, the technique would revolutionise medicine, not least by providing protection against infectious diseases and biological weapons. So in 2013 America’s Defence Advanced Research Projects Agency (darpa) gambled. It awarded a small, new firm called Moderna $25m to develop the idea. Eight years, and more than 175m doses later, Moderna’s covid-19 vaccine sits alongside weather satellites, gps, drones, stealth technology, voice interfaces, the personal computer and the internet on the list of innovations for which darpa can claim at least partial credit.
….
On paper, the approach is straightforward. Take enormous, reckless gambles on things so beneficial that only a handful need work to make the whole venture a success. As Arun Majumdar, founding director of arpa-e, America’s energy agency, puts it: “If every project is succeeding, you’re not trying hard enough.” Current (unclassified) darpa projects include mimicking insects’ nervous systems in order to reduce the computation required for artificial intelligence and working out how to protect soldiers from the enemy’s use of
genome-editing technologies.
“}}

Learning to Love G.M.O.s – The New York Times

August 7, 2021

QT:{{”
In his talk, Baker noted that there are hundreds of kinds of berries in the world. But among those we commonly call berries, we eat just four: strawberries, raspberries, blueberries and blackberries. There’s a reason the other varieties rarely reach us. Sometimes the fruit rots within days after picking (salmonberries), or the plant puts out fruit for only a few weeks in summer (cloudberries)….
Black raspberries, one fruit that Pairwise hopes to bring to market, used to be widely grown in North America, until a virus decimated them. (The red raspberries we eat now originally came from Turkey.) The revived version, which will be in field trials in 2024, has been engineered to be thornless and seedless, while retaining the fruit’s signature jammy flavor.
“}}

https://www.nytimes.com/2021/07/20/magazine/gmos.html

iPad Notebook export for The Tale of the Dueling Neurosurgeons: The History of the Human Brain as Revealed by True Stories of Trauma, Madness, and Recovery

July 17, 2021

https://www.goodreads.com/notes/19616957-the-tale-of-the-dueling-neurosurgeons/114528832-mark-gerstein?ref=bsop
Notebook exported from The Tale of the Dueling Neurosurgeons: The History of the Human Brain as Revealed by True Stories of Trauma, Madness, and Recovery

Biology begins to tangle with quantum computing | Nature Methods

July 16, 2021

Technology Feature
Published: 23 June 2021
Biology begins to tangle with quantum computing
Vivien Marx
Nature Methods volume 18, pages715–719 (2021)

QT:{{”

“There’s a lot of buzz about quantum computing,” says Yale University researcher Mark Gerstein, whose projects traverse biology and informatics. Enthusiasm among his colleagues about the prospects of quantum computing is especially high in the physical sciences, and interest is growing in computational biology and biology more generally.


Gerstein co-authored a paper4 that grew from a series of discussions at the National Institute of Mental Health (NIMH), part of the US National Institutes of Health (NIH). It’s part of the NIH’s way of exploring how to support biologists interested and involved in quantum computing, he says. The wider neuroscience community, for example, is interested in how quantum approaches can be applied to deep learning and machine learning.

“}}

https://www.nature.com/articles/s41592-021-01199-z