Posts Tagged ‘quote’

Are You a Carboholic? Why Cutting Carbs Is So Tough – The New York Times

July 25, 2017

QT:{{”
The conventional thinking, held by the large proportion of the many researchers and clinicians I’ve interviewed over the years, is that obesity is caused by caloric excess. They refer to it as an “energy balance” disorder, and so the treatment is to consume less energy (fewer calories) and expend more. When we fail to maintain this prescription, the implication is that we simply lack will power or self-discipline.

“It’s viewed as a psychological issue or even a question of
character,” says Dr. David Ludwig, who studies and treats obesity at Harvard Medical School.

The minority position in this field — one that Dr. Ludwig holds, as do I after years of reporting — is that obesity is actually a hormonal regulatory disorder, and the hormone that dominates this process is insulin. It directly links what we eat to the accumulation of excess fat and that, in turn, is tied to the foods we crave and the hunger we experience. It’s been known since the 1960s that insulin signals fat cells to accumulate fat, while telling the other cells in our body to burn carbohydrates for fuel. By this thinking these carbohydrates are uniquely fattening.

“}}

Are You a Carboholic? Why Cutting #Carbs Is So Tough
https://www.NYTimes.com/2017/07/19/well/eat/are-you-a-carboholic-why-cutting-carbs-is-so-tough.html #Obesity as an energy-balance v hormonal-regulatory disorder

Robert Caro Fourth Volume – The Big Book, by Chris Jones – Esquire

July 25, 2017

The Big Book http://www.Esquire.com/features/robert-caro-0512 Great description of a clinical & cool but productive 4-decade relationship betw. R #Caro & his editor

LBJ #4

QT:{{”
“Gottlieb did the same math and agreed. In an industry that survives mostly by lying to itself, he is an anti-romantic, an
unsentimentalist. When he edits Caro, they sit side by side at a conference table and go through the pile in front of them, page by tattered page, Gottlieb attacking anything that reads too much like writing, too much like nostalgia or indulgence. He and Caro have mellowed with age, but they have fought bitter fights, fights that have caused people to close their office doors hundreds of feet away. “Everything to him is as serious as everything else,” Gottlieb says. “When we came to something like a semicolon, it was war.”

…Gottlieb is the taskmaster. (“I can remember when he told me, ‘Not bad,’ ” Caro says. “Once.”) Gottlieb and Caro, bound for forty years, rarely see each other socially. Theirs is a professional relationship, clear-eyed and clinical.

Yet they are also prisoners of a mutual faith. “Bob is convinced that without me, he cannot function,” Gottlieb says. “I have explained to him for years that it isn’t the truth. It isn’t the truth. But because he believes it to be true, it is true.” And Gottlieb has given over so much of his own life to Caro, has fought so hard over semicolons, because he believes something else to be true. “These books will live forever,” Gottlieb says. “We all know that.””
“}}

Robert Caro Fourth Volume – The Big Book, by Chris Jones – Esquire

July 25, 2017

The Big Book http://www.Esquire.com/features/robert-caro-0512 Great description of a clinical & cool but productive 4-decade relationship betw. R #Caro & his editor

LBJ #4

QT:{{”
“Gottlieb did the same math and agreed. In an industry that survives mostly by lying to itself, he is an anti-romantic, an
unsentimentalist. When he edits Caro, they sit side by side at a conference table and go through the pile in front of them, page by tattered page, Gottlieb attacking anything that reads too much like writing, too much like nostalgia or indulgence. He and Caro have mellowed with age, but they have fought bitter fights, fights that have caused people to close their office doors hundreds of feet away. “Everything to him is as serious as everything else,” Gottlieb says. “When we came to something like a semicolon, it was war.”

…Gottlieb is the taskmaster. (“I can remember when he told me, ‘Not bad,’ ” Caro says. “Once.”) Gottlieb and Caro, bound for forty years, rarely see each other socially. Theirs is a professional relationship, clear-eyed and clinical.

Yet they are also prisoners of a mutual faith. “Bob is convinced that without me, he cannot function,” Gottlieb says. “I have explained to him for years that it isn’t the truth. It isn’t the truth. But because he believes it to be true, it is true.” And Gottlieb has given over so much of his own life to Caro, has fought so hard over semicolons, because he believes something else to be true. “These books will live forever,” Gottlieb says. “We all know that.””
“}}

Methanobrevibacter smithii – Wikipedia

July 22, 2017

https://en.wikipedia.org/wiki/Methanobrevibacter_smithii

QT:{{"
Methanobrevibacter smithii is the predominant archaeon in the human gut. It plays an important role in the efficient digestionof polysaccharides (complex sugars) by consuming the end products of bacterial fermentation. Methanobrevibacter smithii is a single-celled microorganism from the Archaea domain. M. smithii is a methanogen, and a hydrogenotroph that recycles the hydrogen by combining it with carbon dioxide to methane. The removal of hydrogen by M. smithii is thought to allow an increase in the extraction of energy from nutrients by shifting bacterial fermentation to more oxidized end products.[1]
"}}

Glycemic Index and Glycemic Load Chart

July 22, 2017

http://alsearsmd.com/glycemic-index/

http://www.huffingtonpost.com/riva-greenberg/gl-and-gi_b_863126.html

QT:{{"
Q: What is glycemic load in very simple terms?
Susan Weiner: Glycemic load is a ranking system for carbohydrate-rich food that measures the amount of carbohydrates in a serving of food.
Foods with a glycemic load (GL) under 10 are considered low-GL foods and have little impact on your blood sugar; between 10 and 20 moderate-GL foods with moderate impact on blood sugar, and above 20 high-GL foods that tend to cause blood sugar spikes.
Q: How is glycemic load related to glycemic index?
SW: The glycemic index indicates how rapidly a carbohydrate is digested and released as glucose (sugar) into the blood stream. In other words, how quickly foods break down into sugar in your bloodstream. A food with a high GI raises blood sugar more than a food with a medium to low GI.
But the glycemic index does not take into account the amount of carbohydrate in a food. So glycemic load is a better indicator of how a carbohydrate food will affect blood sugar.
"}}

Recent — Patrick Dougherty

July 22, 2017

http://www.stickwork.net/work/#/022017-sarah-p-duke-gardens-duke-university-durham-nc/

The Big Easy

QT:{{"
02/2017 The Big Easy, Sarah P Duke Gardens, Duke University, Durham, NC
Size: approximately 40’ X 20’ and 18’ tall
"}}

Micromort – Wikipedia

July 21, 2017

https://en.wikipedia.org/wiki/Micromort

QT:{{"
A micromort (from micro- and mortality) is a unit of risk defined as one-in-a-million chance of death.[1][2]
"}}

George Church ascribes his visionary ideas to narcolepsy

July 18, 2017

.@GeoChurch ascribes his…ideas to narcolepsy
https://www.StatNews.com/2017/06/08/george-church-narcolepsy Advocates more neurodiversity, ie those w. ASD, OCD, ADD + narcolepsy

QT:{{”
“His condition has persuaded Church of the benefits of, even the need for, neurodiversity, meaning brains that work differently from most others. The world needs people with high-functioning autism and obsessive-compulsive disorder and attention deficit disorder and, yes, narcolepsy, he has come to believe.”
“}}

Quick comment on AI for pharma?

July 18, 2017

Please find the article at link:
https://www.pharma-iq.com/informatics/articles/is-big-pharma-really-on-cusp-of-ai-shake-out-0

Is big pharma really on cusp of AI shake-out?

By: Pharma IQ
Posted: 07/14/2017

QT:{{”

The promises of “disruptive technologies” have failed to live up to expectations in the past. For example, the development of ‘high throughput screening’ – a process that employs robotics to conduct millions of chemical, genetic and pharmacological tests in rapid time – in the 1990s failed to significantly reduce R&D inefficiencies and offered sporadic success rates.

“The major cost in drug R&D is last-phase clinical trials,” said Dr Mark Gerstein, professor of biomedical informatics at Yale University. “It is not clear whether AI can be as useful for these as it has been in target selection for the initial phases.”

“One of the first principles of data mining is that history is a good predictor of the future. AI has a track record of not living up to its expectations and therefore caution about how great its impact will be in the healthcare industry is now warranted.”
“}}

In Rural Oasis, Serpico Finds New Adversaries – NYTimes.com

July 14, 2017

In Rural Oasis, #Serpico Finds New Adversaries
http://www.NYTimes.com/2013/07/05/nyregion/for-serpico-who-fought-police-corruption-a-new-conflict-over-woodland.html Famous cop from the past protecting #trees from a McMansion developer

QT:{{”
“But now Mr. Serpico’s serenity has been broken and he finds himself battling a new nemesis. This time, it is not an entire agency, but a local developer and town officials who Mr. Serpico says have ignored his complaints; this time, it is not over issues like taking cash payments from drug dealers, but over the fate of some trees and the desecration of pristine woodland.

“It’s like fighting the system again,” Mr. Serpico said. “Here I’m trying to enjoy my tranquillity and I’m being dragged back into a world of corruption.”
“}}