Posts Tagged ‘brainspan’

Genome-wide prediction and functional characterization of the genetic basis of autism spectrum disorder | Nature Neuroscience

July 27, 2018

Genome-wide prediction & functional characterization of the genetic basis of autism spectrum disorder, by @OlgaTroyanskaya lab
https://www.Nature.com/articles/nn.4353 Intersected candidate #ASD genes w/ #BrainSpan gene expression to find a pre-natal signal for the disease

Nature 03142018 Single cell rnaseq of development of human brain Pfc

March 18, 2018

https://www.nature.com/articles/nature25980

A single-cell RNA-seq survey of the developmental landscape of the human prefrontal cortex

Suijuan Zhong
, Shu Zhang
[…]
Xiaoqun Wang
Nature
doi:10.1038/nature25980

The Brain That Couldn’t Remember – The New York Times

March 5, 2018

The #Brain That Couldn’t Remember
http://www.NYTimes.com/2016/08/07/magazine/the-brain-that-couldnt-remember.html Fight over the ownership of HM’s highlights issues in consent HT @FearLoathingBTX

A Code for Autism | Proto Magazine

December 16, 2017

http://protomag.com/articles/code-autism

Thoughts on the PsychENCODE workshop & Psychiatric Genomics in the Era of Team Science – 2 recent DC meetings on Neurogenomics

July 10, 2017

https://linkstream2.gerstein.info/tag/i0pec17/

Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism. – PubMed – NCBI

July 10, 2017

https://www.ncbi.nlm.nih.gov/pubmed/24267886

Cell. 2013 Nov 21;155(5):997-1007. doi: 10.1016/j.cell.2013.10.020.

Coexpression networks implicate human midfetal deep cortical projection neurons in the pathogenesis of autism.

Willsey AJ1, Sanders SJ, Li M, Dong S, Tebbenkamp AT, Muhle RA, Reilly SK, Lin L, Fertuzinhos S, Miller JA, Murtha MT, Bichsel C, Niu W, Cotney J, Ercan-Sencicek AG, Gockley J, Gupta AR, Han W, He X, Hoffman EJ, Klei L, Lei J, Liu W, Liu L, Lu C, Xu X, Zhu Y, Mane SM, Lein ES, Wei L, Noonan JP, Roeder K, Devlin B, Sestan N, State MW.

Using brainspan to see where ASD genes are enriched in certain developmental times

Single Cell Analysis paper

June 30, 2017

http://genome-tech.ucsd.edu/public/Lake_Science_2016/
https://twitter.com/mikejg84/status/880240608144531456

16 Neuronal subtypes & [inter-regional] diversity revealed by [#singlecell]-nucleus RNAseq of…the brain
http://science.sciencemag.org/content/352/6293/1586.long

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain.
Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, Shen R, Ronaghi M, Fan JB, Wang W, Chun J, Zhang K.
Science. 2016 Jun 24;352(6293):1586-90. doi: 10.1126/science.aaf1204.

A comprehensive transcriptional map of primate brain development

June 19, 2017

A…transcriptional map of primate (macaque) #brain development http://www.Nature.com/nature/journal/vaop/ncurrent/full/nature18637.html Gene expression changes more rapidly before birth
Nature (2016) doi:10.1038/nature18637

Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors : Nature Genetics : Nature Research

May 6, 2017

http://www.nature.com/ng/journal/v49/n5/full/ng.3818.html

Ref component analysis..of transcriptomes, by @Robson_Paul &co http://www.Nature.com/ng/journal/v49/n5/full/ng.3818.html Clustering similarity of samples to tissue references

You’re an Adult. Your Brain, Not So Much.

December 26, 2016

Your an adult. Your brain, not so much by @CarlZimmer
http://www.nytimes.com/2016/12/21/science/youre-an-adult-your-brain-not-so-much.html Non-obvious ethical implications of developmental neuroscience

QT:{{”
“The human brain reaches its adult volume by age 10, but the neurons that make it up continue to change for years after that. The connections between neighboring neurons get pruned back, as new links emerge between more widely separated areas of the brain.

Eventually this reshaping slows, a sign that the brain is maturing. But it happens at different rates in different parts of the brain.

The pruning in the occipital lobe, at the back of the brain, tapers off by age 20. In the frontal lobe, in the front of the brain, new links are still forming at age 30, if not beyond.

“It challenges the notion of what ‘done’ really means,” Dr. Somerville said.

As the anatomy of the brain changes, its activity changes as well. In a child’s brain, neighboring regions tend to work together. By adulthood, distant regions start acting in concert. Neuroscientists have speculated that this long-distance harmony lets the adult brain work more efficiently and process more information.”
“}}