Posts Tagged ‘cancer’

Cancer’s Invasion Equation

October 30, 2017

Cancer’s Invasion Eqn, by @DrSidMukherjee
https://www.NewYorker.com/magazine/2017/09/11/cancers-invasion-equation terms: Soil-v-seed, metastasis matching + overcoming “denominator” problem

QT:{{”

“This is medicine’s “denominator problem.” The numerator is you—the person who gets ill. The denominator is everyone at risk, including all the other passengers who were exposed. Numerators are easy to study. Denominators are hard. Numerators come to the doctor’s office, congested and miserable. They get blood tests and prescriptions. Denominators go home from the subway station, heat up dinner, and watch “The Strain.” The numerator persists. The denominator vanishes.” “}}

Haplotype-based profiling of subtle allelic imbalance with SNP arrays

October 21, 2017

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3530675/

Discovering novel pharmacogenomic biomarkers by imputing drug response in cancer patients from large genomics studies

October 21, 2017

Geeleher cites http://genome.CSHLP.org/content/early/2017/08/28/gr.221077.117?top=1 … Novel pharmacogenomic biomarkers by imputing drug response in cancer..from…genomics studies #ASHG17
http://genome.cshlp.org/content/early/2017/08/28/gr.221077.117?top=1

Assembly-based inference of B-cell receptor repertoires from short read RNA sequencing data with V’DJer | Bioinformatics | Oxford Academic

September 30, 2017

Assembly-based inference of Bcell receptor repertoires from..RNAseq w/
V’DJer https://academic.OUP.com/bioinformatics/article/32/24/3729/2525640/Assembly-based-inference-of-B-cell-receptor Less diversity assoc w/ long survival

Breaking Into The Brain | Chemical & Engineering News

September 22, 2017

Breaking Into the #Brain
http://CEN.ACS.org/articles/92/i2/Breaking-Brain.html Contrasts potential for drug discovery in neuro-diseases v #cancer (which is “easier”)

interesting brain v cancer contrast

Whole-genome landscapes of major melanoma subtypes : Nature : Nature Research

September 4, 2017

Hayward, Nicholas K., et al. "Whole-genome landscapes of major melanoma subtypes." Nature 545.7653 (2017): 175-180.

Whole-genome landscapes of…#melanoma subtypes http://www.Nature.com/nature/journal/vaop/ncurrent/full/nature22071.html Sun-exposed cutaneous w. many C>T SNVs v acral/mucosal w. many SVs

Naked mole rats: Can they help us cure cancer? – Slate Magazine

July 31, 2017

Naked mole rats: Can they help..cure cancer?
http://www.Slate.com/articles/health_and_science/the_mouse_trap/2011/11/naked_mole_rats_can_they_help_us_cure_cancer_.html Live >6x longer than C57BL/6 & have “insectile” queen-domimated society

FYI – Personalized Medicine: Redefining Cancer Treatment

July 3, 2017

https://www.kaggle.com/c/msk-redefining-cancer-treatment

A Big Bang model of human colorectal tumor growth : Nature Genetics : Nature Research

June 7, 2017

https://www.nature.com/ng/journal/v47/n3/full/ng.3214.html

Big Bang model of…tumor growth, v. slow #evolution under selection https://www.Nature.com/ng/journal/v47/n3/full/ng.3214.html #Cancer is born w/ key mutations all there

Andrea Sottoriva,
Haeyoun Kang,
Zhicheng Ma,
Trevor A Graham,
Matthew P Salomon,
Junsong Zhao,
Paul Marjoram,
Kimberly Siegmund,
Michael F Press,
Darryl Shibata
& Christina Curtis

Nature Genetics 47, 209–216 (2015) doi:10.1038/ng.3214

Cell Signaling by Receptor Tyrosine Kinases: Cell

May 20, 2017

[category scilit]

Cell signaling by #RTKs Nice 1st fig showing 20 sub-families and architecture of extra- & intra- cellular domains