Posts Tagged ‘cancer’

Genes, environment, and “bad luck” | Science

March 26, 2017

Genes, environment & bad luck
http://science.ScienceMag.org/content/355/6331/1266 To what degree are #cancer mutations due to replication error (3rd factor), not 1st 2?

discusses R v D correlation

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention Cristian Tomasetti1,2,*, Lu Li2, Bert Vogelstein3,*
Science 24 Mar 2017:
Vol. 355, Issue 6331, pp. 1330-1334
DOI: 10.1126/science.aaf9011
http://science.sciencemag.org/content/355/6331/1330

Transmissible Dog Cancer Genome Reveals the Origin and History of an Ancient Cell Lineage | Science

March 4, 2017

Transmissible Dog Cancer Genome Reveals…History of an Ancient Cell Lineage http://science.sciencemag.org/content/343/6169/437.full After 11k yrs 2M SNVs & 646 genes KO’ed

Elizabeth P. Murchison1,2,*,†,
David C. Wedge1,*,
Ludmil B. Alexandrov1,
Beiyuan Fu1,
Inigo Martincorena1,
Zemin Ning1,
Jose M. C. Tubio1,
Emma I. Werner1,
Jan Allen3,
Andrigo Barboza De Nardi4,
Edward M. Donelan3,
Gabriele Marino5,
Ariberto Fassati6,
Peter J. Campbell1,
Fengtang Yang1,
Austin Burt7,
Robin A. Weiss6,
Michael R. Stratton1,†

+ See all authors and affiliations

Science 24 Jan 2014:
Vol. 343, Issue 6169, pp. 437-440
DOI: 10.1126/science.1247167

TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants | eLife

March 4, 2017

TP53 copy number expansion is associated w…enhanced DNA damage response in elephants https://elifesciences.org/content/5/e11994 18 p53 retro- & pseudo- genes

Computational tools for cancer immunology : Computational genomics tools for dissecting tumour-immune cell interactions : Nature Reviews Genetics : Nature Research

February 24, 2017

http://www.nature.com/nrg/journal/v17/n8/fig_tab/nrg.2016.67_T1.html

Table 1: Computational tools for cancer immunology
FromComputational genomics tools for dissecting tumour–immune cell interactions
Hubert Hackl,
Pornpimol Charoentong,
Francesca Finotello
& Zlatko Trajanoski
Nature Reviews Genetics 17, 441–458 (2016) doi:10.1038/nrg.2016.67

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution: Cell

February 4, 2017

Temporal Collateral Sensitivity in Tumor…Evolution
http://www.cell.com/cell/abstract/S0092-8674(16)30059-9 Drug-fitness landscape illuminates transiently vulnerable state

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Boyang Zhao
Joseph C. Sedlak
Raja Srinivas
Pau Creixell
Justin R. Pritchard
Bruce Tidor
Douglas A. Lauffenburger
Michael T. Hemann

Why Elephants Don’t Get Cancer—and What That Means for Humans

December 17, 2016

Why Elephants Don’t Get Cancer – many TP53 copies
http://www.newsweek.com/2015/10/16/researchers-studying-elephants-improve-cancer-treatment-380822.html Result of #Peto’s Paradox: More cells don’t lead to more disease
see dog species

Protein-structure-guided discovery of functional mutations across 19 cancer types : Nature Genetics : Nature Research

December 11, 2016

Protein-structure-guided discovery of functional mutations across 19 #cancer types http://www.nature.com/ng/journal/v48/n8/abs/ng.3586.html Cancer3D relates SNVs to drugs

http://www.nature.com/ng/journal/v48/n8/abs/ng.3586.html

CML, BCR-ABL

October 7, 2016

https://en.wikipedia.org/wiki/Philadelphia_chromosome

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency — NEJM

September 18, 2016

http://www.nejm.org/doi/full/10.1056/NEJMoa1500596#t=article

Please support this campaign from a former PhD student to fight a rare #cancer

September 5, 2016

Please support this campaign from a former PhD student
(@lengjingworld) to fight a rare #cancer
https://www.youcaring.com/jing-leng-637267 OligoNation_Jing