Posts Tagged ‘cancer’

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution: Cell

February 4, 2017

Temporal Collateral Sensitivity in Tumor…Evolution
http://www.cell.com/cell/abstract/S0092-8674(16)30059-9 Drug-fitness landscape illuminates transiently vulnerable state

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Boyang Zhao
Joseph C. Sedlak
Raja Srinivas
Pau Creixell
Justin R. Pritchard
Bruce Tidor
Douglas A. Lauffenburger
Michael T. Hemann

Why Elephants Don’t Get Cancer—and What That Means for Humans

December 17, 2016

Why Elephants Don’t Get Cancer – many TP53 copies
http://www.newsweek.com/2015/10/16/researchers-studying-elephants-improve-cancer-treatment-380822.html Result of #Peto’s Paradox: More cells don’t lead to more disease
see dog species

Protein-structure-guided discovery of functional mutations across 19 cancer types : Nature Genetics : Nature Research

December 11, 2016

Protein-structure-guided discovery of functional mutations across 19 #cancer types http://www.nature.com/ng/journal/v48/n8/abs/ng.3586.html Cancer3D relates SNVs to drugs

http://www.nature.com/ng/journal/v48/n8/abs/ng.3586.html

CML, BCR-ABL

October 7, 2016

https://en.wikipedia.org/wiki/Philadelphia_chromosome

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency — NEJM

September 18, 2016

http://www.nejm.org/doi/full/10.1056/NEJMoa1500596#t=article

Please support this campaign from a former PhD student to fight a rare #cancer

September 5, 2016

Please support this campaign from a former PhD student
(@lengjingworld) to fight a rare #cancer
https://www.youcaring.com/jing-leng-637267 OligoNation_Jing

Harnessing the Immune System to Fight Cancer

August 15, 2016

Harnessing the Immune System to Fight #Cancer
http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html Highlights @BMSnews checkpoint inhibitors Yervoy & Opdivo

Just five sunburns increase your cancer risk – Health News – NHS Choices

July 22, 2016

Just 5 #sunburns [when young] increase your #cancer risk, by 80% for
melanoma http://www.nhs.uk/news/2014/06June/Pages/Just-five-sunburns-increases-your-cancer-risk.aspx As determined from surveys of nurses

Integrative analyses reveal a long noncoding RNA-mediated sponge regulatory network in prostate cancer : Nature Communications : Nature Publishing Group

July 2, 2016

lncRNA-mediated sponge regulatory network in prostate cancer http://www.nature.com/ncomms/2016/160315/ncomms10982/full/ncomms10982.html Few explicitly noted #pseudogenes besides PTENP1

Lalonde E*, Ishkanian AS*, ….P’ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG (2014) “Tumour genomic a nd microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study” La ncet Oncology 15(13):1521-1532 (PMID: 25456371)

May 17, 2016

Genomic & microenvironmental heterogeneity as integrated predictors for prostate #cancer recurrence
http://www.ncbi.nlm.nih.gov/pubmed/25456371 CNVs & hypoxia

* Lalonde E*, Ishkanian AS*, ….P’ng C, Collins CC, Squire JA, Jurisica I, Cooper C, Eeles R, Pintilie M, Dal Pra A, Davicioni E, Lam WL, Milosevic M, Neal DE, van der Kwast T, Boutros PC, Bristow RG (2014) “Tumour genomic and microenvironmental heterogeneity as integrated predictors for prostate cancer recurrence: a retrospective study” Lancet Oncology 15(13):1521-1532 (PMID: 25456371)

The novelty of the paper is that it is the first study integrating DNA-based signatures and microenviroment-based signature for cancer prognosis. The authors found four prognostic indices, i.e. cancer genomic subtype (generated from clusters of CNV profiles), genomic instability (represented by the percentage of genome alteration), DNA signature (276 genes identified from random forests), and tumor hypoxia (the microenvironment signature), to be effective in predicting patient survival in different groups. Standard clinical univariate and multivariate analyses were performed.