Posts Tagged ‘evolution’

Platypus genome

May 5, 2021

Somatic evolution and global expansion of an ancient transmissible cancer lineage | Science

April 14, 2020

Adrian Baez-Ortega1, Kevin Gori1,*, Andrea Strakova1,*, Janice L. Allen2, Karen M. Allum3, Leontine Bansse-Issa4, …. Michael R. Stratton62, Ludmil B. Alexandrov63, Iñigo Martincorena62, Elizabeth P. Murchison1,†

Science 02 Aug 2019:
Vol. 365, Issue 6452, eaau9923
DOI: 10.1126/science.aau9923

Evogeneao: The Tree of Life

December 2, 2017

Evogeneao: The Tree of Life Nice web tool. Particularly good for interactively #visualizing human #evolution relative to that of other species

Cancer’s Invasion Equation

October 30, 2017

Cancer’s Invasion Eqn, by @DrSidMukherjee terms: Soil-v-seed, metastasis matching + overcoming “denominator” problem


“This is medicine’s “denominator problem.” The numerator is you—the person who gets ill. The denominator is everyone at risk, including all the other passengers who were exposed. Numerators are easy to study. Denominators are hard. Numerators come to the doctor’s office, congested and miserable. They get blood tests and prescriptions. Denominators go home from the subway station, heat up dinner, and watch “The Strain.” The numerator persists. The denominator vanishes.” “}}

A Big Bang model of human colorectal tumor growth : Nature Genetics : Nature Research

June 7, 2017

Big Bang model of…tumor growth, v. slow #evolution under selection #Cancer is born w/ key mutations all there

Andrea Sottoriva,
Haeyoun Kang,
Zhicheng Ma,
Trevor A Graham,
Matthew P Salomon,
Junsong Zhao,
Paul Marjoram,
Kimberly Siegmund,
Michael F Press,
Darryl Shibata
& Christina Curtis

Nature Genetics 47, 209–216 (2015) doi:10.1038/ng.3214

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution: Cell

February 4, 2017

Temporal Collateral Sensitivity in Tumor…Evolution Drug-fitness landscape illuminates transiently vulnerable state

Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution

Boyang Zhao
Joseph C. Sedlak
Raja Srinivas
Pau Creixell
Justin R. Pritchard
Bruce Tidor
Douglas A. Lauffenburger
Michael T. Hemann

The Ascent of Mammals – Scientific American

July 4, 2016

The Ascent of #Mammals Overview of their slow growth & coexistence w. dinosaurs, not just advent after KT asteroid

Identification of neutral tumor evolution across cancer types : Nature Genetics : Nature Publishing Group

February 27, 2016

Neutral tumor #evolution across #cancer types Initial burst of driver events followed by random mutations

Boutros PC…., van der Kwast T, Bristow RG* (2015) “Spatial genomic heterogeneity within localized, mult i-focal prostate cancer” Nature Genetics 47(7):736-745 (PMID: 26005866)

January 25, 2016

Spatial genomic heterogeneity w/in…prostate #cancer WGS analysis of many sites suggests divergent tumor evolution

Boutros…, van der Kwast, Bristow (2015) “Spatial genomic
heterogeneity within localized, multi-focal prostate cancer” Nature Genetics 47(7):736-745 (PMID: 26005866)

This work represents the first systematic relation of intraprostatic genomic heterogeneity to predicted clinical outcomes at the level of whole-genome sequencing (WGS). Five patients, with index tumors of Gleason score 7, were subjected to a WGS protocol with spatial sampling of 23 distinct tumor regions to assess intraprostatic heterogeneity. In their analysis, Boutros et al, discovered recurrent amplification of MYCL, which is associated with TP53 loss. This finding is one of the first clear functional distinctions between MYC family members in prostate cancer and suggests that MYCL amplification may be preferentially localized in the index lesion. Overall, the authors believe their results are useful in the development of prognostic biomarkers that are necessary to achieve personalized prostate cancer medicine. It is important to note that such diagnostic biopsy protocols can miss regions of more aggressive cancers resulting in the patient being under-staged.

PLOS Computational Biology: Catalysis of Protein Folding by Chaperones Accelerates Evolutionary Dynamics in Adapting Cell Populations

December 18, 2015

Folding by Chaperones Accelerates Evolutionary Dynamics Multiscale models link NT mutations, PPIs & cell populations