https://www.nature.com/articles/d41586-026-02897-4
QT:{{” The trait could explain why symptoms vary in severity between people with similar brain pathology. “}}
Perhaps useful for PD & HD too…
Posts Tagged ‘pdukbb’
Cognitive resilience helps to predict Alzheimer’s dementia | Nature
October 16, 2026Psychiatry has finally found an objective way to spot mental illness | New Scientist
April 1, 2026Robson, D. (2026, January 16). Psychiatry has finally found an objective way to spot mental illness. New Scientist.
https://www.newscientist.com/article/2509966-psychiatry-has-finally-found-an-objective-way-to-spot-mental-illness/
QT:{{”
“It is the fusion of these features that allows us to reach high levels of accuracy and reliability,” says Aafjes. “In cases of severe depression, non-verbal behaviours are often the most informative signals – aspects one might miss by analysing voice and speech alone.” Working with scientists at the Baylor College of Medicine in Texas, Deliberate Al is investigating how biomarkers change during recovery. “We’ve shown high concurrent validity with existing measures, which is very important for acceptability by regulators and clinicians,” says Aafjes. “}}
Newsci-article-in-labdropbox–2026-04-01 22.53.35.jpg
Newsci-article-in-labdropbox–2026-04-01 22.53.50.jpg
Concepts, estimation and interpretation of SNP-based heritability – Nature Genetics
February 22, 2026See Box 1, viz:
QT:{{”
Box 1 Statistical model used in the GREML approach to estimate hS2NP The statistical model used by GREML can be described in its simplest form as y = Wu + e
where y is an n x 1 vector of standardized phenotypes with n equal to the sample size, W = {wij} is an n x m standardized SNP genotype matrix where m is the number of SNPs, u = {ui} is an m x 1 vector of the additive effects of all variants when fitted jointly in the model, u ~ N(0,Iσ2) with I being an identity matrix, u and e is a vector of residuals, e ~ N(0,Iσ2). An equivalent model is….
y=g+e
g ~ N(0,A…)
A=W W’
In practice, A is called the SNP-derived genetic (or genomic) relationship matrix (GRM) and is estimated from the SNP data. The estimate …from GREML can be described as the estimated variance explained by all the SNPs (mσu) or equivalently as the estimated genetic variance by contrasting the phenotypic similarity
between unrelated individuals to their SNP-derived genetic similarity “}}
https://www.nature.com/articles/ng.3941
Yang, J., Zeng, J., Goddard, M. E., Wray, N. R., & Visscher, P. M. (2017). Concepts, estimation and interpretation of SNP-based heritability. Nature Genetics, 49(9), 1304–1310.
https://doi.org/10.1038/ng.3941
