Posts Tagged ‘future0mg’

The human disease network | PNAS

January 1, 2026

https://www.pnas.org/doi/10.1073/pnas.0701361104?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed QT:{{” We find that essential human genes are likely to encode hub proteins and are expressed widely in most tissues. This suggests that disease genes also would play a central role in the human interactome. In contrast, we find that the vast majority of disease genes are nonessential and show no tendency to encode hub proteins, and their expression pattern indicates that they are localized in the functional periphery of the network. “}}

Goh, K., Cusick, M. E., Valle, D., Childs, B., Vidal, M., & Barabási, A. (2007). The human disease network. Proceedings of the National Academy of Sciences, 104(21), 8685–8690.
https://doi.org/10.1073/pnas.0701361104

POSTER: ‘Human Knockout Project’ in a Pakistani Population with High Levels of Consanguinity – Mass General Advances in Motion

January 1, 2026

https://advances.massgeneral.org/cardiovascular/article.aspx?id=1014 QT:{{” “}}

Darwin Machines and the Nature of Knowledge – Henry Plotkin – Google Books

January 1, 2026

https://books.google.com/books/about/Darwin_Machines_and_the_Nature_of_Knowle.html?id=Q6vsdBdWkc8C QT:{{” Learn and survive. Behind this simple equation lies a revolution in the study of knowledge, which has left the halls of philosophy for the labs of science. This book offers a cogent account of what such a move does to our understanding of the nature of learning, rationality, and intelligence. Bringing together
evolutionary biology, psychology, and philosophy, Henry Plotkin presents a new science of knowledge, one that traces an unbreakable link between instinct and our ability to know. Contrary to the modern liberal idea that knowledge is something derived from experience, this science shows us that what we know is what our nature allows us to know, what our instincts tell us we must know. Since our ability to know our world depends primarily on what we call intelligence, intelligence must be understood as an extension of instinct. Drawing on contemporary evolutionary theory, especially notions of
hierarchical structure and universal Darwinism, Plotkin tells us that the capacity for knowledge, which is what makes us human, is deeply rooted in our biology “}}

Two Patients Declared ‘Cured’ of Leukemia a Decade After CAR T Cell Immunotherapy Infusion | University of Pennsylvania | Pathology and Laboratory Medicine

January 1, 2026

https://pathology.med.upenn.edu/news/two-patients-declared-cured-leukemia-decade-after-car-t-cell-immunotherapy-infusion#:~:text=A%20new%20analysis%20of%20the,Don%20Siegel%20and%20Bruce%20Levine.

what is car t therapy – Google Search

January 1, 2026

https://www.google.com/search?q=what+is+car+t+therapy&oq=what+is+CAR+T+ther&gs_lcrp=EgZjaHJvbWUqBwgAEAAYgAQyBwgAEAAYgAQyBggBEEUYOTIHCAIQABiABDIHCAMQABiABDIHCAQQABiABDIHCAUQABiABDIHCAYQABiABDIHCAcQABiABDIICAgQABgWGB4yCAgJEAAYFhge0gEIOTQ2MGowajeoAgCwAgA&sourceid=chrome&ie=UTF-8 QT:{{” CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) is a personalized immunotherapy that genetically modifies a patient’s own T-cells (a type of white blood cell) in a lab to create
supercharged cancer-fighting cells, which are then infused back into the patient to find and destroy specific cancer cells, particularly effective for some blood cancers like leukemia and lymphoma that don’t respond to other treatments.
How it works:

T-cell Collection (Apheresis): Your T-cells are drawn from your blood, usually through a vein, and the rest of your blood is returned to you. Genetic Modification: In a specialized lab, a deactivated virus inserts new genes into your T-cells, creating Chimeric Antigen Receptors (CARs) on their surface, essentially turning them into “GPS-guided” missiles.
Expansion: These CAR T-cells multiply in the lab until there are millions of them.
Infusion: The lab-grown CAR T-cells are infused back into your body, often after a short course of chemotherapy to prepare you, where they hunt down and kill cancer cells.

“}}

Source: American College of Veterinary Surgeons

December 29, 2025

https://www.acvs.org/large-animal/laryngeal-hemiplegia-in-horses/

Source: American College of Veterinary Surgeons Laryngeal Hemiplegia in Horses – American College of Veterinary Surgeons
https://share.google/PQvvRFHQNb4DGRAve

First Minimal Synthetic Bacterial Cell | J. Craig Venter Institute

December 29, 2025

https://www.jcvi.org/research/first-minimal-synthetic-bacterial-cell QT:{{” Researchers from the J. Craig Venter Institute (JCVI) and Synthetic Genomics, Inc. (SGI) have accomplished the next feat in synthetic biology research—the design and construction of the first minimal synthetic bacterial cell, JCVI-syn3.0.
Using the first synthetic cell, Mycoplasma mycoides JCVI-syn1.0 (built by this same team in 2010), JCVI-syn3.0 was developed through a design, build, and test (DBT) process using genes from JCVI-syn1.0. The new minimal synthetic cell contains only 531,000 base pairs and just 473 genes making it the smallest genome of any self-replicating organism. “}}

Creating a functional single-chromosome yeast – PubMed

December 29, 2025

https://pubmed.ncbi.nlm.nih.gov/30069045/
QT:{{” Eukaryotic genomes are generally organized in multiple chromosomes. Here we have created a functional single-chromosome yeast from a Saccharomyces cerevisiae haploid cell containing sixteen linear chromosomes, by successive end-to-end chromosome fusions and centromere deletions. The fusion of sixteen native linear chromosomes into a single chromosome results in marked changes to the global three-dimensional structure of the chromosome due to the loss of all centromere-associated inter-chromosomal interactions, most
telomere-associated inter-chromosomal interactions and 67.4% of intra-chromosomal interactions. However, the single-chromosome and wild-type yeast cells have nearly identical transcriptome and similar phenome profiles. The giant single chromosome can support cell life, although this strain shows reduced growth across environments, competitiveness, gamete production and viability. “}}

Arthur Samuel (computer scientist) – Wikipedia

December 29, 2025

https://en.wikipedia.org/wiki/Arthur_Samuel_(computer_scientist) QT:{{” Arthur Lee Samuel (December 5, 1901 – July 29, 1990)[3] was an American pioneer in the field of computer gaming and artificial intelligence.[2] He popularized the term “machine learning” in 1959.[4] The Samuel Checkers-playing Program was among the world’s first successful self-learning programs, and as such a very early demonstration of the fundamental concept of artificial intelligence (AI).[5] “}}

…from here to DeepBlue & AlphaGo

Selective Attention/ Invisible Gorilla Experiment: See Through Your Focus – Academy 4SC Learning Hub

December 29, 2025

https://learn.academy4sc.org/video/selective-attention-invisible-gorilla-experiment-see-through-your-focus/#:~:text=The%20study%20was%20conducted%20in,a%20gorilla%20thumping%20its%20chest. QT:{{” The study was conducted in 1999 at Harvard University. It involved a short video of people in white t-shirts and black t-shirts passing a basketball to people in the same colored shirt. Participants were asked to watch this video and count the number of passes the white team made. Most could correctly list the number of passes and thought it was a relatively easy task. Yet despite this, over half of the participants failed to notice a person in a gorilla suit walk between the basketball players, stand and face the camera, bang their chest, and walk offscreen.

This goes against nearly everyone’s intuition: we’d expect to be able to spot such an obvious occurrence. Yet repeated studies have gathered similar results: we aren’t as observant as we like to think. If we don’t expect to see something, odds are we won’t notice it. Selective attention has its benefits, but it can cause you to miss out on something as obvious as a gorilla thumping its chest.
“}}