Archive for the 'SciLit' Category

Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression | Bioinformatics | Oxford Academic

May 3, 2021

Nice analysis integrating bulk & single-cell data, to get at inter-individual differences in the expression of genes in specific
cell types https://academic.OUP.com/bioinformaticsformatics/article/36/3/782/5545976

Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression

https://academic.oup.com/bioinformatics/article/36/3/782/5545976

Prior SARS-CoV-2 infection rescues B and T cell responses to variants after first vaccine dose | Science

May 2, 2021

https://science.sciencemag.org/content/early/2021/04/29/science.abh1282

Pre-symptomatic detection of COVID-19 from smartwatch data | Nature Biomedical Engineering

April 28, 2021

https://www.nature.com/articles/s41551-020-00640-6

Human local adaptation of the TRPM8 cold receptor along a latitudinal cline

April 7, 2021

Stumbled onto this paper. Thought the conclusion that Europeans were more cold-sensitive due to TRPM8 was quite counter-intuitive – but interesting nevertheless
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007298

cold receptor

Massively parallel ultrafast random bit generation with a chip-scale laser | Science

March 29, 2021

https://science.sciencemag.org/content/371/6532/948

Low rattling: A predictive principle for self-organization in active collectives | Science

January 29, 2021

https://science.sciencemag.org/content/371/6524/90

pseudogenes/odorant receptors

December 17, 2020

Sequence Variants in TAAR5 & Other Loci Affect Human Odor Perception & Naming https://www.cell.com/current-biology/fulltext/S0960-9822(20)31343-9 A variant in TAAR5 affects the perception of fish odor. Interesting to consider in relation to pseudogenization of the olfactory receptors

While about half of human odorant receptors are thought to be pseudogenes with loss-of-function, the Decode Genetics folks show that some sequence variants in odorant receptor genes are not
loss-of-function.

A human cell atlas of fetal gene expression | Science

November 14, 2020

https://science.sciencemag.org/content/370/6518/eaba7721

+
https://science.sciencemag.org/content/370/6518/eaba7612

15 tissues (incl. brain), fetal, RNA+atac

BY JUNYUE CAO, DIANA R. O’DAY, HANNAH A. PLINER, PAUL D. KINGSLEY, MEI DENG, RIZA M. DAZA, MICHAEL A. ZAGER, KIMBERLY A. ALDINGER, RONNIE BLECHER-GONEN, FAN ZHANG, MALTE SPIELMANN, JAMES PALIS, DAN DOHERTY, FRANK J. STEEMERS, IAN A. GLASS, COLE TRAPNELL, JAY SHENDURE SCIENCE13 NOV 2020

What will drive computer performance after Moore’s law?

November 11, 2020

https://science.sciencemag.org/content/368/6495/eaam9744

Determinants of telomere length across human tissues | Science

September 27, 2020

https://science.sciencemag.org/content/369/6509/eaaz6876.full Nice relationship to aging; related to Me analysis