Nice analysis integrating bulk & single-cell data, to get at inter-individual differences in the expression of genes in specific
cell types https://academic.OUP.com/bioinformaticsformatics/article/36/3/782/5545976
Using multiple measurements of tissue to estimate subject- and cell-type-specific gene expression
https://academic.oup.com/bioinformatics/article/36/3/782/5545976
Stumbled onto this paper. Thought the conclusion that Europeans were more cold-sensitive due to TRPM8 was quite counter-intuitive – but interesting nevertheless
https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1007298
cold receptor
Sequence Variants in TAAR5 & Other Loci Affect Human Odor Perception & Naming https://www.cell.com/current-biology/fulltext/S0960-9822(20)31343-9 A variant in TAAR5 affects the perception of fish odor. Interesting to consider in relation to pseudogenization of the olfactory receptors
While about half of human odorant receptors are thought to be pseudogenes with loss-of-function, the Decode Genetics folks show that some sequence variants in odorant receptor genes are not
loss-of-function.
https://science.sciencemag.org/content/370/6518/eaba7721
+
https://science.sciencemag.org/content/370/6518/eaba7612
15 tissues (incl. brain), fetal, RNA+atac
BY JUNYUE CAO, DIANA R. O’DAY, HANNAH A. PLINER, PAUL D. KINGSLEY, MEI DENG, RIZA M. DAZA, MICHAEL A. ZAGER, KIMBERLY A. ALDINGER, RONNIE BLECHER-GONEN, FAN ZHANG, MALTE SPIELMANN, JAMES PALIS, DAN DOHERTY, FRANK J. STEEMERS, IAN A. GLASS, COLE TRAPNELL, JAY SHENDURE SCIENCE13 NOV 2020
https://science.sciencemag.org/content/369/6509/eaaz6876.full Nice relationship to aging; related to Me analysis
