Sequence of events in prostate #cancer, by @MarkARubin1
http://www.Nature.com/articles/d41586-018-06029-5 Discusses the high prevalence of AR-enhancer amplifications in recent studies
QT:{{”
“Quigley and colleagues performed whole-genome sequencing of 101 samples of metastatic, castration-resistant prostate-cancer tissue obtained from previous studies11,12. The most frequently altered genomic site identified was the AR-enhancer region, which was amplified in 81% of samples. The high prevalence of this type of amplification is notable because enhancer amplifications identified so far for other cancer types generally arise at much lower
frequency13–16. Moreover, the high prevalence of this AR-enhancer amplification in the data presented by Viswanathan and Quigley contrasts with its occurrence in only 1 of 54 previously published whole-genome sequences of prostate-cancer samples obtained before clinical treatment had commenced17.”
“}}
Archive for the 'SciLit' Category
Sequence of events in prostate cancer
October 5, 2018GTEx sex differential expression paper
September 5, 2018Mind control as a guide for the mind | Nature Human Behaviour
August 18, 2018Mind control as a guide for the mind | Nature Human Behaviour
Modeling RNA Secondary Structure with Sequence Comparison and Experimental Mapping Data: Biophysical Journal
August 18, 2018Modeling RNA Secondary Structure with Sequence Comparison &
Experimental Mapping Data
https://www.Cell.com/biophysj/fulltext/S0006-3495(17)30689-6 combines TurboFold sec. structure prediction w/ results of SHAPE assays
Zhen Tan
Gaurav Sharma
David H. Mathews
Open Archive Published:July 20, 2017
DOI:https://doi.org/10.1016/j.bpj.2017.06.039
Addressing the minimum fleet problem in on-demand urban mobility | Nature
August 17, 2018Addressing the minimum fleet problem in on-demand urban mobility by @mmvazifeh, @stevenstrogatz et al.
https://www.Nature.com/articles/s41586-018-0095-1 Solved by putting taxis & their riders into a large #network
Muons: the little-known particles helping to probe the impenetrable
August 17, 2018Muons: the little-known particles helping to probe the impenetrable, via @NaturePodcast https://www.Nature.com/articles/d41586-018-05254-2 Using “muography” to see into the ground, beneath volcanos & into pyramids
New study finds cell line difference across labs
August 16, 2018https://www.nature.com/articles/s41586-018-0409-3
QT:{{”
“… comprehensive genomic characterization of 27 strains of the common breast cancer cell line MCF7 uncovered rapid genetic
diversification. Similar results were obtained with multiple strains of 13 additional cell lines.
“}}
genome-wide starr-seq + sources of experimental bias
August 12, 2018quite relevant
https://www.nature.com/articles/nmeth.4534
Resolving systematic errors in widely used enhancer activity assays in human cells
Felix Muerdter
, Łukasz M Boryń
, Ashley R Woodfin
, Christoph Neumayr
, Martina Rath
, Muhammad A Zabidi
, Michaela Pagani
, Vanja Haberle
, Tomáš Kazmar
, Rui R Catarino
, Katharina Schernhuber
, Cosmas D Arnold
& Alexander Stark
Nature Methods volume 15, pages141–149 (2018)
text mining and privacy
August 4, 2018Don’t quote me: reverse identification of research participants in social media studies
John W. Ayers,
Theodore L. Caputi,
Camille Nebeker &
Mark Dredze
npj Digital Medicine
volume 1, Article number: 30 (2018)
