https://www.biorxiv.org/content/10.64898/2026.08.25.746866v1
Chen, R., Huang, L., Qiao, Y., Mandal, S., Mo, L., Li, L., Leshchiner, D., Zhang, X., Pu, J., Xie, Y., Girgis, R., Ellsworth, E., Huang, L., Chen, X., Li, X., Zhou, J., & Chen, B. (2026). A pretrained unified model enables cellular functional profile prediction and
multi-objective virtual drug screening. bioRxiv (Cold Spring Harbor Laboratory). https://doi.org/10.64898/2026.08.25.746866
Marek, S., Donohue, M. R., Karcher, N. R., Hoyniak, C. P., Chauvin, R. J., Meyer, A. C., Miller, J., Van, A. N., Wang, A., Baden, N. J., Suljic, V., Scheidter, K. M., Monk, J., Whiting, F. I., Ramirez-Perez, N. J., Krimmel, S. R., Metoki, A., Paul, S. E., Gorelik, A. J., . . . Dosenbach, N. U. F. (2026). Patterns of brain-wide associations reflect socioeconomics. Science, 392(6803), eaee6213.
https://doi.org/10.1126/science.aee6213
BWAS
https://www.science.org/doi/10.1126/sciadv.aec7965
smells peanut
18jun
Chemistry42: An AI-Driven Platform for Molecular Design and
Optimization – PMC https://pmc.ncbi.nlm.nih.gov/articles/PMC9930109/
https://pmc.ncbi.nlm.nih.gov/articles/PMC11738990/
QT:{{”
Using AI-driven methodology, we generated INS018_055, a small-molecule TNIK inhibitor, which exhibits desirable drug-like properties and anti-fibrotic activity across different organs in vivo through oral, inhaled or topical administration…. Its safety and tolerability as well as pharmacokinetics were validated in a randomized,
double-blinded, placebo-controlled phase I clinical trial
(NCT05154240) involving 78 healthy participants.
“}}
Ren, F., Aliper, A., Chen, J., Zhao, H., Rao, S., Kuppe, C., Ozerov, I. V., Zhang, M., Witte, K., Kruse, C., Aladinskiy, V., Ivanenkov, Y., Polykovskiy, D., Fu, Y., Babin, E., Qiao, J., Liang, X., Mou, Z., Wang, H., . . . Zhavoronkov, A. (2024). A small-molecule TNIK inhibitor targets fibrosis in preclinical and clinical models. Nature Biotechnology, 43(1), 63–75.
https://doi.org/10.1038/s41587-024-02143-0
https://www.sciencedirect.com/science/article/abs/pii/S0262407926012352
the prediction machine new scientist
world models
QT:{{”
Indoor air pollution has serious immediate and long-term consequences; however, ensuring that indoor air is clean has not been a high priority for societies. One of the consequences of neglecting indoor air quality is the presence of pathogenic viruses in indoor air. They cause local outbreaks of the common cold and seasonal influenza epidemics or pandemics, which are often caused by novel viruses. ….
First, most modern public buildings—such as offices, shopping malls, or entertainment venues—are mechanically ventilated and do not have windows that can be opened (Fig. 2). It is expected that they are adequately ventilated, but, in reality, this is often not the case (16). Contemporary buildings are not designed with provision of good indoor air quality as a requirement, and specifically not with an objective of controlling airborne infection transmissions.
“}}
https://www.science.org/doi/10.1126/science.adp2241
Morawska, L., Li, Y., & Salthammer, T. (2024). Lessons from the COVID-19 pandemic for ventilation and indoor air quality. Science, 385(6707), 396–401. https://doi.org/10.1126/science.adp2241
https://pmc.ncbi.nlm.nih.gov/articles/PMC9541182/
QT:{{” We observe that this widespread recommendation to open the window of a quarantine room and to seal the door is based on the consideration of a single zone model. We illustrate the importance of moving from such a single zone approach to a multizone approach for quantifying ventilation and airing impacts in multizone buildings as residences in order to prevent epidemics of viruses such as
SARS‐CoV‐2. It highlights the need of air leakage databases. “}}
Guyot, G., Sayah, S., Guernouti, S., & Mélois, A. (2022). Role of ventilation on the transmission of viruses in buildings, from a single zone to a multizone approach. Indoor Air, 32(8), e13097.
https://doi.org/10.1111/ina.13097
