Commentary
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data Carolyn Hutter + Jean Claude Zenklusen
https://www.sciencedirect.com/science/article/pii/S009286741830374X
Archive for the 'SciLit' Category
The Cancer Genome Atlas: Creating Lasting Value beyond Its Data
June 15, 2018Papers for Journal Club
June 7, 2018Alternative evolutionary histories in the sequence space of an ancient protein https://www.Nature.com/articles/nature23902 Great viz of different potential but not necessarily realized evolutionary trajectories. Quite relevant for molecular #evolution & #pseudogenes
Potential role for microglia in Alzheimer’s
June 2, 2018Alzheimer’s may be caused by haywire immune system eating brain connections Study targets new mechanism in fight against cognitive decline
Computationally-designed synthetic protein assemblies that evolve like viruses | Nature Research Microbiology Community
May 22, 2018Evolution of a designed protein assembly encapsulating its own RNA genome https://www.Nature.com/articles/nature25157 The opposite, in a sense, of #BioInspired. Computational design of man-made virus capsid
ALSO:
Computationally-designed synthetic protein assemblies that evolve like viruses | Nature Research Microbiology Community
Paper for Journal Club Tomorrow
May 22, 2018Susceptibility of brain atrophy to TRIB3 in #Alzheimer’s disease, evidence from functional prioritization in imaging genetics
http://www.PNAS.org/content/115/12/3162.long Nice connection of developing phenotypes from #imaging, combined w. simple polygenic scores from genotypes
Genome-Scale Signatures of Gene Interaction from Compound Screens Predict Clinical Efficacy of Targeted Cancer Therapies – ScienceDirect
April 28, 2018Genome-Scale Signatures of Gene Interaction from #CompoundScreens Predict…Efficacy of Targeted Cancer Therapies
https://www.ScienceDirect.com/science/article/pii/S2405471218300097 How to find drug combos: Find expression response profiles associated w/ a drug target. A synergistic drug might change profiles similarly
Cryo-EM structure of substrate-bound human telomerase holoenzyme | Nature
April 28, 2018#CryoEM structure of substrate-bound human telomerase holoenzyme https://www.Nature.com/articles/s41586-018-0062-x Quote: “2 flexibly RNA-tethered lobes: the catalytic core (w/ #TERT & conserved motifs of telomerase RNA) & an H/ACA RNP”
systematic comparison of dnase-seq & atac-seq
April 21, 2018Reproducible inference of TF footprints in #ATACseq & DNase-seq…via protocol-specific bias modeling
https://www.BiorXiv.org/content/early/2018/03/19/284364 Systematic comparison of the 2 assay HT @gamzeandgursoy
Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression | eLife
April 21, 2018Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression https://eLifeSciences.org/articles/25125 More noncoding than coding #allelic activity. Also, finding windows of allelic activity for chromatin
Daniel Andergassen,
Christoph P Dotter,
Daniel Wenzel,
Verena Sigl,
Philipp C Bammer,
Markus Muckenhuber,
Daniela Mayer,
Tomasz M Kulinski,
Hans-Christian Theussl,
Josef M Penninger,
Christoph Bock,
Denise P Barlow ,
Florian M Pauler ,
Quanah J Hudson
Research Center for Molecular Medicine of the Austrian Academy of Sciences, Austria;
Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Austria;
Institute of Molecular Pathology, Austria
