Dopamine receptor D4 – Wikipedia, the free encyclopedia

July 24, 2016

Novelty seeking
Despite early findings of an association between the DRD4 48bp VNTR and novelty seeking (a characteristic of exploratory and excitable people),[19][20] a 2008 meta-analysis compared 36 published studies of novelty seeking and the polymorphism and found no effect. The meta-analysis of 11 studies did find that another polymorphism in the gene, the -521C/T, showed an association with novelty seeking.[12] While human results are controversial, an increasing body of animal evidence has linked DRD4 variants with novelty seeking,
e.g.,,,[21][22][23][24][25] and new evidence suggests that human encroachment may exert selection pressure in favor of DRD4 variants associated with novelty seeking.[26] Novelty-seeking behavior is probably mediated by several genes, and the variance attributable to DRD4 by itself is not particularly large.[citation needed]