Aminopterin – Wikipedia, the free encyclopedia

August 13, 2016

Discovered by Dr. Yellapragada Subbarow, the drug was first used by Sidney Farber in 1947 to induce remissions among children with leukemia.[2][3] Aminopterin was later marketed by Lederle Laboratories (Pearl River, New York) in the United States from 1953 to 1964 for the indication of pediatric leukemia. The closely related antifolate methotrexate was simultaneously marketed by the company during the same period. Aminopterin was discontinued by Lederle Laboratories in favor of methotrexate due to manufacturing difficulties…