Why sports concussions are worse for women

September 4, 2021

Smith’s team knew from imaging and brain-tissue studies that axon fibres from the brains of female rats and humans are slimmer than those from males. They wanted to know more about the differences and what effect they might have on brain injury, so they cultured rat neurons and then damaged them by exposing them to a rapid air blast. In the neurons from female rats, the axons were smaller and the microtubules narrower and more susceptible to damage than in the cells from males. The same was true for cultured human neurons5.