https://pubmed.ncbi.nlm.nih.gov/37968396/
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…most yeast proteins interact with at least sixteen others. The highly organised yeast interactome includes 3,927 proteins linked by 31,004 interactions….Much like human social networks (such as Facebook), the average shortest path between any two proteins in yeast involves just four interactions. So while most protein ‘nodes’ are not directly connected, there is on average just four degrees of separation between them. This organisation, characterised by local clustering and relatively short average path lengths between nodes, is known as a small-world network.
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from WOOLFSON et al. (’26)