Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation | Nature Genetics

January 25, 2026

https://github.com/calico/borzoi

N&V – https://www.nature.com/articles/s41588-025-02154-w

https://www.nature.com/articles/s41588-024-02053-6#:~:text=This%20paper%20proposes%20a%20new%20machine%2Dlearning%20model%2C,that%20drive%20RNA%20expression%20and%20post%2Dtranscriptional%20regulation QT:{{” ere, we introduce Borzoi, a model that learns to predict cell-type-specific and tissue-specific RNA-seq coverage from DNA sequence. “}}

Linder, J., Srivastava, D., Yuan, H., Agarwal, V., & Kelley, D. R. (2025). Predicting RNA-seq coverage from DNA sequence as a unifying model of gene regulation. Nature Genetics, 57(4), 949–961.
https://doi.org/10.1038/s41588-024-02053-6