https://www.google.com/search?q=migration+of+keratinocytes+from+the+stratum+basale&oq=migration+of+ker&gs_lcrp=EgZjaHJvbWUqBwgBEAAYgAQyBggAEEUYOTIHCAEQABiABDIHCAIQABiABDIICAMQABgWGB4yCAgEEAAYFhgeMggIBRAAGBYYHjIICAYQABgWGB4yCAgHEAAYFhgeMggICBAAGBYYHjIICAkQABgWGB7SAQg4NjQ5ajBqNKgCALACAA&sourceid=chrome&source=chrome.ob&ie=UTF-8 QT:{{” Keratinocytes migrate upward from the Stratum Basale to the outer skin surface in about 2 to 4 weeks. [1, 2]
The Migration Process
Origin: Cells start in the deepest layer of the epidermis, called the stratum basale, where stem cells divide to create new keratinocytes. [1, 2]
Journey: As new cells form, they push older cells upward through the intermediate layers: the stratum spinosum and the stratum granulosum. [1, 2]
Change (Differentiation): During this upward movement, cells change shape, flatten, produce keratin protein, and lose their nuclei to become dead, protective cells called corneocytes. [1, 2, 3]
Shedding (Desquamation): The flattened cells reach the outermost layer—the stratum corneum—stay there for roughly two weeks, and then shed off the body. [1, 2]
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