In fact, these authors showed that the association based on DNA methylation outperformed the polygenic risk scores on the same patients, driven substantially by variability due to ancestry and cell type composition estimates derived from DNA methylation data. These results suggest that we may be seeing DNA methylation in action as a molecular sentinel reflect- ing many biological responses by host cells. Many of the laboratory results studied reflected age-associated conditions (e.g., hemoglobin A1C, choles- terol, indices of renal function), raising the intriguing possibility that aging clocks based on DNA methylation may be reflective of the sum of many age-associated
biomarkers. As there is a lot of current discussion about the value of implementing polygenic risk scores as part of population health (Lewis and Vassos 2020), we can anticipate a subsequent wave of interest in the use of methylation risk scores instead, if they continue to show better potential as instruments allowing personalized, precision medicine.
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Quotes from Epigenetics
May 16, 2026Quotes from Epigenetics
May 16, 2026The upshot is a circus of epigenetic diets, epigenetic face creams and other cosmetics, epigenetic yoga and meditation, and even epigenetic antidandruff shampoo, all to be found with a search of the internet. The foundation in evidence for any of these interventions is, at best, extreme- ly weak. The resulting collective eye roll from the broader scientific com- munity demands a response from epigenetics
researchers, who individually may be performing rigorous research but who collectively suffer from what would be described in the world of marketing as “brand damage.”
Quotes from Epigenetics
May 16, 2026Book starts with…..
Semantic has become a term of dismissal. That’s just semantics…, I’m not go- ing to enter into a semantic argument with you…, if you want to get seman- tic about it…—you use the word today to suggest that the discussion is not worth your while. It’s as if semantic is taking on the meaning of pedantic, the excessive, inappropriate, and annoying attention to minor details, in Finland described (impolitely) as pilkunnussija or (politely) one who has intimate intercourse with commas.
In telling the story of epigenetics, you must embrace semantics while keeping your inner pedant firmly under control. Today, this rich and fasci- nating avenue of scientific enquiry has not only captured imaginations, it has also captured multiple meanings. Two people discussing epigenetics may think they are talking about the same concept but have completely different and even opposing views of what it means. Someone seeking to construct a hypothesis based on epigenetics can find scraps of evidence from the multi- ple
definitional buckets, building a structure that to the uncritical eye may look solid but lacks the compatible mortises and tenons for stability.
The Mark Restaurant & Bar | Jean Georges Restaurants NYC
May 16, 2026frontdesk
SSID=”The Mark”
https://www.themarkhotel.com/restaurant-bars/the-mark-bar/#the-mark-bar lots of salads, open late
I wore Meta’s smartglasses for a month – and it left me feeling like a creep
May 16, 2026I wore Meta’s smartglasses for a month – and it left me feeling like a creep | AI (artificial intelligence) | The Guardian
https://www.theguardian.com/technology/2026/apr/01/i-wore-metas-smartglasses-for-a-month-and-it-left-me-feeling-like-a-creep
The Breakthrough: Immunotherapy and the Race to Cure Cancer: Graeber, Charles: 9781455568505: Amazon.com: Books
May 16, 2026College Announces 2026 Valedictorian and Salutatorian | Columbia College
May 13, 2026Goldberg is a computational biology major with a double minor in statistics, and science and society.
….
“As a faculty adviser to the new major in computational biology, I have been especially impressed by Goldberg’s pioneering spirit,” says Itsik Pe’er, professor of computer science and systems biology at Columbia Engineering. As the first student — and for a while the only student — to take on this still-emerging program, she embraced the intellectual challenge of a curriculum that asks students to move fluently across computer science, biology and quantitative analysis. “}}
Columbia’s New Comp Bio Major
linkstream2 microblog 