https://www.theatlantic.com/health/archive/2018/04/sacklers-oxycontin-opioids/557525/
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Nan Goldin, P.A.I.N. Group Stage Protest Against Sackler Family, Purdue Pharmaceuticals in Met’s Sackler Wing – ARTnews.com
August 15, 2021JSPLAY
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August 15, 2021The Parent Trap (1961 film) – Wikipedia
August 15, 2021The unvaccinated are at risk as evolution accelerates the covid-19 pandemic | The Economist
August 14, 2021QT:{{”
In the original Wuhan genome the 501st position in the spike chain is occupied by an amino acid called asparagine. ….Mutations which cause just that substitution, known as n501y (or sometimes “Nelly”) subsequently turned up in the Alpha, Beta and Gamma variants. Another change they spotted, now called e484k (or “Eek”), was found in both Beta and Gamma.
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The rbd is not the only part of the spike protein where mutations matter. In a preprint published on June 22nd Ravindra Gupta, a molecular virologist at Cambridge University, and his colleagues put forward an argument as to why Delta is both more infectious and better at evading immunity than other variants. It is based on a substitution at site 681, which is at the point where, after the rbd meets ace2, the protein is cleft in two.
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Dr Gupta says p681r, helped by two shape-modifying mutations elsewhere, makes it easier for the protein to be cut up and thus get into cells. Its presence also means that, once a cell starts producing particles, their spike proteins can get on to the cell’s surface pre-cut.
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The long goodbye to covid-19 | The Economist
August 14, 2021https://www.economist.com/leaders/2021/07/03/the-long-goodbye-to-covid-19
QT:{{
“In Britain, where Delta is dominant, the fatality rate if you become infected is now about 0.1%, similar to seasonal flu: a danger, but a manageable one.”
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Liked the “shifts”!
Also, thought the following quote was quite interesting: “In Britain, where Delta is dominant, the fatality rate if you become infected is now about 0.1%, similar to seasonal flu.” So if we get covid & flu shots each year, both diseases will become comparable, in a sense? Mark Gerstein
