Archive for the '–' Category

DNA Sequencing Giant Illumina Will Buy Pacific Biosciences For $1.2 Billion – Exclusive CEO Interview

November 3, 2018

We’re now all ILLUMINATED: DNA Sequencing Giant $ILMN Will Buy @PacBio For $1.2B, by @MatthewHerper
https://www.Forbes.com/sites/matthewherper/2018/11/01/dna-sequencing-giant-illumina-will-buy-pacific-biosciences-for-12-billion–exclusive-ceo-interview/ After raising $360M from VCs + $200M from an IPO

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“Pacific Biosciences was originally supposed to be an Illumina-killer. Founded in 2003 by chief technology officer, Steven Turner, who invented the firm’s basic technology with PacBio’s chief scientific officer, Jonas Korlach, PacBio emerged in 2009 boasting that it would disrupt the sequencing market, raising $360 million in venture capital and scoring a $200 million initial public offering. But its machines were too slow, expensive and unwieldy to slow down Illumina’s ascent. Shares plummeted, and even at the rich premium being offered by Illumina, shares are at half the IPO price.”
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An Aging Marathoner Tries to Run Fast After 40 | WIRED

November 3, 2018

https://www.wired.com/story/aging-marathoner-tries-to-run-fast-after-40/

Michael Specter: The Growing Battle Over How to Treat Lyme Disease : The New Yorker

November 3, 2018

http://www.newyorker.com/reporting/2013/07/01/130701fa_fact_specter

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“The disease is caused by the bacterium Borrelia burgdorferi. In the Northeast and the Midwest, B. burgdorferi is transmitted by the bite of a black-legged tick, Ixodes scapularis. (In the Western United States, a related tick, Ixodes pacificus, prevails, and in Europe the main vector is Ixodes ricinus.) Lyme was all but unknown until 1977, when Allen Steere, a rheumatologist at Yale, produced the first definitive account of the infection. The condition was initially thought to have been an outbreak of juvenile rheumatoid arthritis in and around Lyme, Connecticut. In 1982, Willy Burgdorfer, a medical entomologist at the National Institutes of Health’s Rocky Mountain Laboratories, determined that the infection was caused by the previously unknown spirochete borrelia. As is common in scientific practice, the bacterium was named for him: Borrelia burgdorferi.”

“The controversy over Lyme disease is unlikely to diminish until scientists resolve at least two critical, but related, questions. Can the bacteria persist in the body, causing harm and illness months or even years after treatment has ended? And can prolonged antibiotic therapy destroy the remaining bacteria?”
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How to Create a Strong Password That You Will Not Forget

November 3, 2018

https://www.makeuseof.com/tag/create-strong-password-forget/

Dopamine receptor D2 – Wikipedia – DRD2

November 3, 2018

https://en.wikipedia.org/wiki/Dopamine_receptor_D2

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Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2gene. After work from Paul Greengard’s lab had suggested that dopamine receptors were the site of action of antipsychotic drugs, several groups (including those of Solomon Snyder and Philip Seeman) used a radiolabeled antipsychotic drug to identify what is now known as the dopamine D2receptor.[5] The dopamine D2 receptor is the main receptor for most antipsychotic drugs. The structure of DRD2 in complex with the atypical antipsychotic risperidone has been determined.[6]
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NMDA receptor – Wikipedia

November 3, 2018

https://en.wikipedia.org/wiki/NMDA_receptor

QT:{{”
The N-methyl-D-aspartate receptor (also known as the NMDA receptor or NMDAR), is a glutamate receptor and ion channel protein found in nerve cells. The NMDA receptor is one of three types of ionotropic glutamate receptors. The other receptors are the AMPA and kainate receptors. It is activated when glutamate and glycine (or D-serine) bind to it, and when activated it allows positively charged ions to flow through the cell membrane.[2] The NMDA receptor is very important for controlling synaptic plasticity and memory function.[3]
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Anti-NMDAR Encephalitis | Center for Autoimmune Neurology | Perelman School of Medicine at the University of Pennsylvania

November 3, 2018

https://www.med.upenn.edu/autoimmuneneurology/nmdar-encephalitis.html

John Eccles (neurophysiologist) – Wikipedia

November 3, 2018

https://en.wikipedia.org/wiki/John_Eccles_(neurophysiologist)

Spindle neuron – Wikipedia

November 3, 2018

https://en.wikipedia.org/wiki/Spindle_neuron

iPad Notebook export for Consciousness and the Brain: Deciphering How the Brain Codes Our Thoughts

November 3, 2018

Some quick quotes from
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Consciousness and the Brain: Deciphering How the Brain Codes Our Thoughts Dehaene, Stanislas
Citation (MLA): Dehaene, Stanislas. Consciousness and the Brain: Deciphering How the Brain Codes Our Thoughts. Penguin Publishing Group, 2014. Kindle file.
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that I really liked

Each short quote below is in order as it appears in book

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These two anecdotes are reported by Jacques Hadamard, a world-class mathematician who dedicated a fascinating book to the mathematician’s mind.75 Hadamard deconstructed the process of mathematical discovery into four successive stages: initiation, incubation, illumination, and verification.
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It is crucial to understand that, in this sort of coding scheme, the silent neurons, which do not fire, also encode information. Their muteness implicitly signals to others that their preferred feature is not present or is irrelevant to the current mental scene. A conscious content is defined just as much by its silent neurons as by its active ones.
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As we discussed in Chapter 5, the prefrontal cortex, a pivotal hub of the conscious workspace, occupies a sizable portion of any primate’s brain—but in the human species, it is vastly expanded.45 Among all primates, human prefrontal neurons are the ones with the largest dendritic trees.46
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One of these regions, called the frontopolar cortex, or Brodmann’s area 10, is larger in Homo sapiens than in any other ape.
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Another special region is Broca’s area, the left inferior frontal region that plays a critical role in human language.
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At a more microscopic level, the huge pyramidal cells in the dorsolateral prefrontal cortex (layers 2 and 3), with their extensive dendrites capable of receiving thousands of synaptic connections, are much smaller in schizophrenic patients. They exhibit fewer spines, the terminal sites of excitatory synapses whose enormous density is characteristic of the human brain. This loss of connectivity may well play a major causal role in schizophrenia. Indeed, many of the genes that are disrupted in schizophrenia affect either or both of two major molecular neurotransmission systems, the dopamine D2 and glutamate NMDA receptors,
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Most interesting, perhaps, is that normal adults experience a transient schizophrenia-like psychosis when taking drugs such as phencyclidine (better known as PCP, or angel dust) and ketamine. These agents act by blocking neuronal transmission, quite specifically, at excitatory synapses of the NMDA
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