http://www.nature.com/news/encode-the-human-encyclopaedia-1.11312
Archive for the 'PopSci' Category
ENCODE: The human encyclopaedia : Nature News & Comment
October 10, 2012UConn Gets Grant For Genome Research – Courant.com
October 10, 2012The ever deepening mystery of the human genome – life – 05 September 2012 – New Scientist
October 7, 2012Diagnostics-Drugs Pairings Advance Personalized Medicine | July 23, 2012 Issue – Vol. 90 Issue 30 | Chemical & Engineering News
October 4, 2012http://cen.acs.org/articles/90/i30/Diagnostics-Drugs-Pairings-Advance-Personalized.html
Good article about how companion diagnostics for making personalized med. are taking off
QT:”
Within two weeks last August, the U.S. Food & Drug Administration approved two new cancer drugs: Roche’s Zelboraf, also called vemurafenib, for metastatic melanoma and Pfizer’s Xalkori, or crizotinib, for non-small-cell lung cancer. What sets those drugs apart from other cancer treatments is the requirement that physicians use a diagnostic test to determine whether each one is right for a patient. In the year since their approval, the two drugs have become poster children for personalized medicine and for what the industry calls “companion diagnostics.”
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Xalkori and Zelboraf are not the first drugs to use companion diagnostics. That honor goes to Herceptin, Genentech’s drug for HER2 (human epidermal growth factor receptor 2)-positive breast cancer, which was approved in 1998.
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Roche’s path began in 2002, when scientists discovered that mutations in the BRAF gene, which encodes an enzyme involved in cell signaling, are involved in some cases of metastatic melanoma. By 2005, Plexxikon, Roche’s partner in developing Zelboraf, had designed a drug to inhibit the mutated B-Raf kinase expressed by the aberrant gene. Plexxikon contacted Roche Molecular Systems to see whether the diagnostics company could develop a test for the mutation.
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On July 6, FDA approved a companion diagnostic from Qiagen to identify appropriate patients for a new indication for the cancer drug cetuximab, which is comarketed by Eli Lilly & Co. and Bristol-Myers Squibb as Erbitux.
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The biopharmaceutical company Endocyte is built on the idea of companion diagnostics, says Ron Ellis, president and chief executive officer.
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Related to this:
The genesis of Zelboraf: Targeting mutant B-Raf in melanoma
Matthew J. Davis and Joseph Schlessinger
http://jcb.rupress.org/content/199/1/15
ENCODE project sheds light on human DNA and disease – latimes.com
September 30, 2012http://www.latimes.com/news/science/la-sci-dna-encode-20120906,0,7798745.story
Definitely plays junk DNA story a bit strong, with ENCODE “upending conventional wisdom”
linkstream2 microblog 