Y sequencing by Page et al.
Archive for the 'SciLit' Category
Strict evolutionary conservation followed rapid gene loss on human and rhesus Y chromosomes.
August 21, 2013HeLa Cells Contaminating Other Cell Lines
August 21, 2013Arch Pathol Lab Med. 2009 Sep;133(9):1463-7. doi: 10.1043/1543-2165-133.9.1463.
Henrietta Lacks, HeLa cells, and cell culture contamination.
Lucey BP, Nelson-Rees WA, Hutchins GM.
latest Nature paper with cancer data
August 21, 2013500 whole-genome cancer sequences
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature12477.html
Evolution of the Caenorhabditis elegans Genome
August 10, 2013this should partially explain the high insertion rate in worm: http://mbe.oxfordjournals.org/content/26/6/1199.full
QT:”
Of the new mutations observed in MA lines, more than half were short indel mutations, with fewer deletions than insertions (Denver, Morris, Lynch, and Thomas 2004). This finding on indels contrasts with previous work with C. elegans pseudogenes in which deletions are more common than insertions (Robertson 2000; Witherspoon and Robertson 2003) but is consistent with findings in C. elegansmicrosatellite mutation data (Frisse 1999; Denver, Morris, Kewalramani, et al. 2004; Seyfert et al. 2008).
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The CRAPome: a contaminant repository for affinity purification-mass spectrometry data : Nature Methods : Nature Publishing Group
August 9, 2013FYI: Another Encode Commentary Paper
August 4, 2013Mattick & Dinger
The extent of functionality in the human genome
http://www.thehugojournal.com/content/7/1/2/
PLOS Collections: A Primer on Regression Methods for Decoding cis-Regulatory Logic
August 4, 2013#Regression Methods for Decoding cis-Regulatory Logic, incl. interaction terms & non-linear sigmoidal relationships
http://www.ploscollections.org/article/info%3Adoi%2F10.1371%2Fjournal.pcbi.1000269
Global Epigenomic Reconfiguration During Mammalian Brain Development
July 27, 2013Lister… Ecker
MT @BiomedRevon: Global #epigenomic reconfiguration during mammalian #brain development http://bit.ly/16lbboa cortex methylation over time
A “map showing how methylation changes in the frontal cortex over time. During the first two years of life… a wave of methylation alters the DNA in genes ”
http://www.sciencemag.org/content/early/2013/07/05/science.1237905
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