Archive for the 'SciLit' Category
Hartwig
April 23, 2022the marker paper of the Hartwig Medical Foundation paper.
Pan-cancer whole-genome analyses of metastatic solid tumours https://www.nature.com/articles/s41586-019-1689-y
Peter Priestley, Jonathan Baber, Martijn P. Lolkema, Neeltje Steeghs, Ewart de Bruijn, Charles Shale, Korneel Duyvesteyn, Susan Haidari, Arne van Hoeck, Wendy Onstenk, Paul Roepman, Mircea Voda, Haiko J. Bloemendal, Vivianne C. G. Tjan-Heijnen, Carla M. L. van Herpen, Mariette Labots, Petronella O. Witteveen, Egbert F. Smit, Stefan Sleijfer, Emile E. Voest & Edwin Cuppen
Nature volume 575, pages
210–216 (2019)
There have been numerous follow-up papers since.
Also, the Glioma Longitudinal Analysis (GLASS) Consortium datasets, which are publicly accessible via www.synapse.org/glass.
The first marker paper is here:
https://www.nature.com/articles/s41586-019-1775-1.
The role of dorsolateral and ventromedial prefrontal cortex in the processing of emotional dimensions | Scientific Reports
April 23, 2022https://www.nature.com/articles/s41598-021-81454-7#:~:text=To%20put%20it%20in%20a,the%20respective%20areas%20does%20hold.
QT:{{”
To put it in a nutshell, the vmPFC is assumed to have a crucial role in emotional processing, whereas the dlPFC is predominantly involved in cognitive control and executive processing.
It is however debatable if such a strict functional distinction of the respective areas does hold.
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Cryptic and abundant marine viruses at the evolutionary origins of Earth’s RNA virome
April 22, 2022Quantification of private information leakage from phenotype-genotype data: linking attacks – PubMed
April 18, 2022Data Sanitization to Reduce Private Information Leakage from Functional Genomics – PubMed
April 18, 2022Mutation bias reflects natural selection in Arabidopsis thaliana | Nature
April 14, 2022https://www.nature.com/articles/s41586-021-04269-6
https://twitter.com/MarkGerstein/status/1510065060806283269
Interesting paper, relating de novo mutation rate to epigenetic features. Wonder exactly how this connects to the fact that the background mutation rate in cancer genomes depends strongly on epigenetics.
Important genomic regions mutate less often than do other regions https://www.nature.com/articles/d41586-022-00017-6
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