#Singlecell ChIPseq reveals…subpopulations defined by chromatin statehttp://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html Sparse data: on order of 1K uniq. reads/cell
http://www.nature.com/nbt/journal/vaop/ncurrent/full/nbt.3383.html
Archive for the 'SciLit' Category
Single-cell ChIP-seq
October 23, 2015Human Genome Project: Twenty-five years of big biology
October 17, 2015HGP: 25yrs of big biology
http://www.nature.com/news/human-genome-project-twenty-five-years-of-big-biology-1.18436 6 lessons: embrace Partnering, data Sharing & Analytics + Tech & ELSI; be Bold & Flexible
QT:{{”
Embrace partnerships. By necessity, the HGP broke the mould of individual researchers toiling away in isolation to answer a small set of scientific questions. It also ran against the grain of
hypothesis-driven research, focusing instead on the discovery of fundamental information that would inform many follow-on
investigations.
…
“}}
Research profiles: A tag of one’s own : Naturejobs
October 10, 2015A tag of one’s own
http://www.nature.com/naturejobs/science/articles/10.1038/nj7572-281aMakes a convincing case for signing up for an ORCHID identifier & linking it to your papers
Panorama of ancient metazoan macromolecular complexes : Nature : Nature Publishing Group
September 26, 2015Panorama of ancient metazoan #macromolecular complexes
http://www.nature.com/nature/journal/v525/n7569/abs/nature14877.html Finding many more #complexes from integrating many co-elutions
http://www.nature.com/nature/journal/v525/n7569/full/nature14877.html#affil-auth
Systematic humanization of yeast genes reveals conserved functions and genetic modularity
September 23, 2015Systematic humanization of yeast genes reveals conserved functions &…modularity http://www.sciencemag.org/content/348/6237/921.abstract #yeast survive in half of 400 swaps
Saturated Reconstruction of a Volume of Neocortex | Lichtman Lab at Harvard
September 23, 2015Punctuated equilibrium in the large-scale evolution of programming languages | Journal of The Royal Society Interface
September 22, 2015Punctuated equilibrium in the large-scale #evolution of #programming languages http://rsif.royalsocietypublishing.org/content/12/107/20150249 Clustering groups these into trees
Punctuated equilibrium in the large-scale evolution of programming languages
Sergi Valverde, Ricard V. Solé
Why Human Disease-Associated Residues Appear as the Wild-Type in Other Species: Genome-Scale Structural Evidence for the Compensation Hypothesis
September 14, 2015Why human disease-associated residues appear as WT in other species http://mbe.oxfordjournals.org/content/31/7/1787.abstract Compensation by their 3D structural neighbors
New life for old bones
September 14, 2015New life for old bones https://www.sciencemag.org/content/349/6246/358.summary An explosion in ancient DNA research. Water & heat hard on DNA, creating a northern bias
linkstream2 microblog 