Archive for the 'SciLit' Category
Intratumor heterogeneity in localized lung adenocarcinomas delineated by multiregion sequencing
April 26, 2015A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? – PubMed – NCBI
April 26, 2015Applies to all rns
http://www.ncbi.nlm.nih.gov/pubmed/21802130
A ceRNA hypothesis: the Rosetta Stone of a hidden RNA language? – PubMed – NCBI
PLOS ONE: Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
April 26, 2015PLOS ONE: Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0030733
Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine : Nature Medicine : Nature Publishing Group
April 26, 2015Whole-exome sequencing and clinical interpretation of formalin-fixed, paraffin-embedded tumor samples to guide precision cancer medicine : Nature Medicine : Nature Publishing Group
http://www.nature.com/nm/journal/v20/n6/abs/nm.3559.html
Describes PHIAL
The External RNA Controls Consortium: a progress report – Nature Methods
April 26, 2015Another ERCC consortia, predates exRNA
http://www.nature.com/nmeth/journal/v2/n10/full/nmeth1005-731.html
“The Race” to Clone BRCA1
April 25, 2015The Race to Clone #BRCA1 http://www.sciencemag.org/content/343/6178/1462.abstract
Lessons on #LOF mutations, synthetic lethality, silly gene names & the 2-hit hypothesis
synthetic lethality (PARP inhibitors), gene names (RING fingers)
Flies Evade Looming Targets by Executing Rapid Visually Directed Banked Turns
April 25, 2015Flies Evade…Targets by Executing Rapid…Banked Turns http://www.sciencemag.org/content/344/6180/172.abstract Amazing ultrafast #movies w/ 7.5K frames/sec & IR lighting
amazing movies in supplement
10x
April 23, 2015http://www.ncbi.nlm.nih.gov/pubmed/25477383
also
http://www.ncbi.nlm.nih.gov/pubmed/25477383
Nucleic Acids Res. 2015 Feb 27;43(4):e23. doi: 10.1093/nar/gku1252. Epub 2014 Dec 3.
Allele-specific copy number profiling by next-generation DNA sequencing. Chen H1, Bell JM2, Zavala NA2, Ji HP2, Zhang NR3.
perhaps related?
Health: Make precision medicine work for cancer care
April 20, 2015Make #precisionmedicine work for cancer http://www.nature.com/news/health-make-precision-medicine-work-for-cancer-care-1.17301 @MarkARubin1: >90% of…patients carry a mutation that may be drug-responsive
QT:{{"
“Hugely complicated genomic reports are rarely available in electronic form and are seldom tied to basic information about the patient. Whole-genome sequencing on tumour samples from nearly 14,000 people by the International Cancer Genome Consortium (ICGC), for instance, has revealed nearly 13 million mutations across the genome.
…
Since 2013, working with a team of computational biologists from Weill Cornell and the Centre for Integrative Biology at the University of Trento in Italy, my colleagues and I have conducted a pilot programme to determine the feasibility of tying genomic to clinical data in real time. So far, we have created easy-to-read reports for 250 people with cancer.
…
We have discovered that more than
"more than 90% of our patients carry a mutation that may be responsive to a known drug — although less than 10% of the patients may be eligible for a clinical trial either for logistical reasons or because there is insufficient evidence to warrant trying a non-approved drug.”
"}}
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