Is Biomedical Innovation Happening Outside the Peer-Reviewed Literature? http://jama.jamanetwork.com/article.aspx?articleid=2110977 Focuses on diagnostics company, #Theranos
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This Viewpoint discusses the need for scientific transparency when biomedical innovation takes place outside of the peer-reviewed literature.
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by J Ioannidis
From noncoding variant to phenotype…at…#cholesterol locus http://www.nature.com/nature/journal/v466/n7307/full/nature09266.html
Gold standard ex of #SNP functional effect: LDL changes
Kiran Musunuru,
Alanna Strong,
Maria Frank-Kamenetsky,
et al.
Nature 466, 714–719 (05 August 2010) doi:10.1038/nature09266
Changes LDL level
Disease-disease relationships through the incomplete interactome, by @barabasi http://www.sciencemag.org/content/347/6224/1257601.abstract #Network modules for 226 diseases
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Altogether, disease genes associated with 226 of the 299 diseases show a statistically significant tendency to form disease modules based on both Si andP(ds) (fig. S4).
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Genome sequence-independent identification of #RNA editing
siteshttp://www.nature.com/nmeth/journal/vaop/ncurrent/full/nmeth.3314.html GIREMI uses LD to separate edit sites from #SNPs
Qing Zhang
& Xinshu Xiao
Nature Methods (2015) doi:10.1038/nmeth.3314Received
Linking #signaling pathways [phospho-proteins in samples] to transcriptional programs [TFs & targets], via matrices
http://genome.cshlp.org/content/24/11/1869.long
More verbosely:
using matrices to linking TF & targets and phosphorsylated proteins in particular samples to gene expression in specific samples
Linking signaling pathways to transcriptional programs in breast cancer
Hatice U. Osmanbeyoglu1,
Raphael Pelossof1,
Jacqueline F. Bromberg2 and
Christina S. Leslie1
Genome Research
Convergent…specializations in brains of humans & songbirds http://www.sciencemag.org/content/346/6215/1256846.long Both have matching expression patterns across regions
Statistical Basis for Predicting Technological Progress
http://trancik.scripts.mit.edu/home/data/
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0052669
Béla Nagy,
J. Doyne Farmer,
Quan M. Bui,
Jessika E. Trancik
Published: February 28, 2013
DOI: 10.1371/journal.pone.0052669
http://www.sciencemag.org/content/early/2009/12/10/science.1181421
Published Online December 10 2009
Science DOI: 10.1126/science.1181421
REPORT
Global Analysis of Short RNAs Reveals Widespread Promoter-Proximal Stalling and Arrest of Pol II in Drosophila
Sergei Nechaev1,
David C. Fargo2,
Gilberto dos Santos1,
Liwen Liu3,
Yuan Gao4 and
Karen Adelman1,*
Is this tetrahedral?
Ir-containing compound w/ a formal #oxidation state of IX http://www.nature.com/nature/journal/v514/n7523/full/nature13795.html
Surpassing OsO4, removing d electron gives [IrO4]+ cation
"Removal of the remaining d electron from IrO4 would lead to the iridium tetroxide cation ([IrO4]+)"
linkstream2 microblog 