Yale School of Medicine Ranks 4th in U.S. for NIH Funding | Yale School of Medicine
February 22, 2026MCB111 Mathematics in Biology
February 22, 2026http://mcb111.org/w06/w06-lecture.html
Has some nice textbook downloads – e.g.
http://mcb111.org/w06/KollerFriedman.pdf
QT:{{”
There are many good books to learn about probabilistic models. “Probabilistic graphical models: principles and techniques” (by Koller & Friedman) is a comprehensive source about more general probabilistic models than the one we are going to study here.
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Subset of chap 7 focuses on GMRF
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February 22, 2026good tutorial/textbook chaper/review paper on Poisson regression :
Below are a few readings that discuss how to fit a generalized linear mixed model.
1. Breslow & Clayton (1993), JASA, Approximate Inference in
Generalized Linear Mixed Models.
https://doi.org/10.2307/2290687
A classic statistical paper introducing the Laplace approximation and penalized quasi-likelihood for GLMMs
2. Bates (2011), Mixed models in R using the lme4 package Part 5: Generalized linear mixed models
https://lme4.r-forge.r-project.org/slides/2011-03-16-Amsterdam/5GLMMH.pdf 3. Bates, D., Mächler, M., Bolker, B., & Walker, S. (2015). Fitting linear mixed-effects models using lme4. Journal of statistical software, 67, 1-48.
https://doi.org/10.18637/jss.v067.i01
4. Bates (2025), Computational methods for mixed models
https://cran.r-project.org/web/packages/lme4/vignettes/Theory.pdf
These are written by the authors of the lme4 package, discussing the details of how a mixed-effects model (more specifically, a generalized linear mixed-effects model) is trained using the PIRLS approach.
Master Equation Notes – Following Up on Your Questions
February 22, 20261. Paulsson (2005) – “Models of stochastic gene expression”
https://www.sciencedirect.com/science/article/abs/pii/S1571064505000138 Nice pedagogical review of the master equation framework – covers the conceptual foundations and different analytical approaches.
2. Shahrezaei & Swain (2008) – “Analytical distributions for stochastic gene expression”
https://pubmed.ncbi.nlm.nih.gov/18988743/
This one derives the exact analytical solutions to the master equation for protein/mRNA distributions.
The Paulsson paper is probably better as a tutorial.
However, it’s a bit difficult to connect to protein & mRNA.
The Differences Between Tylenol, Aleve, Advil, and Aspirin
February 22, 2026Huntington disease | Nature Reviews Disease Primers
February 22, 2026https://www.nature.com/articles/nrdp20155
nrdp20155.pdf
Bates, G. P., Dorsey, R., Gusella, J. F., Hayden, M. R., Kay, C., Leavitt, B. R., Nance, M., Ross, C. A., Scahill, R. I., Wetzel, R., Wild, E. J., & Tabrizi, S. J. (2015). Huntington disease. Nature Reviews Disease Primers, 1(1), 15005.
https://doi.org/10.1038/nrdp.2015.5
What Is a Blepharoplasty? What to Know About the Popular Eyelid Surgery – WSJ
February 22, 2026What Is a Blepharoplasty? What to Know About the Popular Eyelid
Surgery – WSJ https://www.wsj.com/style/beauty/blepharoplasty-eyelid-lift-cosmetic-surgery-cc865580
Equinox chairman: ‘Health is the new luxury’ as wellness spending soars
February 22, 2026A New Concern About Weight Loss Drugs: What if They Work Too Well?
February 22, 2026A New Concern About Weight Loss Drugs: What if They Work Too Well? – The New York Times
https://www.nytimes.com/2026/02/18/well/weight-loss-drugs-retatrutide.html
Source: American Museum of Natural History
February 19, 2026Source: American Museum of Natural History Impact: The End of the Age of Dinosaurs | AMNH https://share.google/vNNUrPck4tTC9Uxxt
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