Source: Lyme Academy of Fine Arts – We are an Academy of professional artists that encourages individuality and innovation through skills-based training.
Composition – Lyme Academy of Fine Arts
Source: Lyme Academy of Fine Arts – We are an Academy of professional artists that encourages individuality and innovation through skills-based training.
January 25, 2025Genome-wide association studies | Nature Reviews Methods Primers
January 25, 2025g accounts for the cumulative effect of all other variants on the phenotype besides the effect of the specific variant being tested (SNP s).
Although theoretically we should consider the effect of g when testing for GWAS associations, in practice don’t think this happens in standard GWAS tools, such as PLINK and REGENIE (see below).
PLINK: https://www.cog-genomics.org/plink/2.0/assoc
REGENIE: https://www.nature.com/articles/s41588-021-00870-7#Sec10
https://www.nature.com/articles/s43586-021-00056-9
Clothes for Cycling in 24 F degrees (with a wind chill of 14)
January 25, 2025long sleeve shirt
2 black “fuzzy” jackets, fairly thick
Patagonia windbreaker
thick Patagonia “sweats”
wool socks
double hothands on each foot
hothands on each hand in a sock
gloves without fingers
bar mitts
2 masks
double cycle cap under helmet
t-shirt + normal underwear
Jimmy Breslin through the lens of true crime: New biography sizzles
January 24, 2025Understanding binary cross-entropy / log loss: a visual explanation | by Daniel Godoy | Towards Data Science
January 20, 2025Media query (Nature Medicine): Quantum computing and health
January 19, 2025Guenot, M. (2025). Can quantum computing crack the biggest challenges in health? Nature Medicine. https://doi.org/10.1038/s41591-024-03369-w
Great story by @Marianne_Guenot, providing good & *not* good news about QC for biomedicine.
QT:{{
The potential power of quantum computers in cracking problems that classical computers cannot is not all good news, says Mark Gerstein, a professor of biomedical informatics at Yale University who recently co-authored a review about quantum computing and health for Nature Methods3.
Experts predict that quantum computers could become fiendishly good at breaking through current encryption algorithms, says Gerstein, which could pose a problem for the privacy of confidential patient data. “There’s a huge push right now to get post-quantum cryptography to work,” he says.
…
The idea, then, is not for quantum computers to replace classical computers, says Gerstein. Instead, they should be considered as adding a node to a computing chain, as each can contribute different strengths to solve a problem. “The art here is figuring out which bit of this big calculation you can quantize,” says Gerstein.
“}}
AI tool that predicts gene activity could open path for disease treatments – The Washington Post
January 18, 2025https://www.washingtonpost.com/science/2025/01/09/ai-predicts-gene-activity/
Johnson, M. (2025, January 8). Scientists trained AI to predict gene activity, a potentially powerful tool. Washington Post.
https://www.washingtonpost.com/science/2025/01/09/ai-predicts-gene-activity/
QT:{{”
Mark Gerstein, a professor of biomedical informatics at Yale School of Medicine, who was not involved in the new study, said that for 15 to 20 years experts have been systematically trying to make predictions about gene regulation, building on a trove of carefully made datasets. The data examined all genes in specific types of human cells ― for example, retinal cells or neurons ― measuring, among other things, gene expression and the binding of key proteins called transcription factors.
“This is a field poised to have this type of advancement by AI,” Gerstein said. “}}
How a Breakthrough Surgery Enables the Brain to Control a Bionic Leg | The New Yorker
January 18, 2025https://www.newyorker.com/magazine/2024/12/16/a-bionic-leg-controlled-by-the-brain
Leg Work
Galchen, R. (2024, December 9). How a breakthrough surgery enables the brain to control a bionic leg. The New Yorker.
https://www.newyorker.com/magazine/2024/12/16/a-bionic-leg-controlled-by-the-brain
