Study reveals unique molecular machinery of woman who can’t feel pain | UCL News – UCL – University College London
December 26, 2024A World Without Pain | The New Yorker
December 26, 2024Levy, A. (2020, January 6). A world without pain. The New Yorker. https://www.newyorker.com/magazine/2020/01/13/a-world-without-pain
QT:{{”
“When I met Jo for the first time, I was just struck by her,” Cox, an affable forty-year-old with a scruffy beard, told me, one afternoon in his lab at U.C.L. …This imperviousness to pain is what makes her distinct from everyone else with a FAAH mutation. They, like even the most committed stoners, can still get hurt.
Cameron had the same FAAH mutation that many other people have—but there had to be something else at play. The scientists started their inquiry by isolating DNA from her blood, and then analyzing the protein-coding subset of her genome—the part that’s traditionally considered to be significant. “We didn’t really find anything,” Cox said. “So we decided, O.K., why don’t we look across the whole genome for bits that are deleted or duplicated? And, at the time, this new chip was just available, which enabled us to scan the whole genome and look for deletions”—snippets missing from her genetic code. “It was a lucky strike: we found that there was this deletion. But it was distinct from FAAH. It was away from FAAH, just downstream.”
The scientists noticed that the right edge of the deletion overlapped “a gene that was annotated as a pseudogene,” Cox said, and frowned. “Which is a term I don’t like.” A pseudogene is what’s been thought of as genetic detritus—a copy of a gene that’s just sitting there, not doing anything productive. One biochemist I spoke to likened a pseudogene to a rusted-out car you stumble on in the forest—only, in Cameron’s case, they put a key in the ignition and the car turned on. “To call it a pseudogene is misleading, because this is a gene that is expressed—it makes a product, a sequence in the DNA,” Cox said, with excitement. “It’s a real fascinating class of genes which have been severely overlooked in genetics until very recently.” Cox and his colleagues named this particular pseudogene—“It’s nicer to call it a gene,” he insisted—FAAH OUT. “It was a wordplay, really,” he said sheepishly. “The challenge now is to understand what it’s doing. Jo is the first person in the world that we know of with this.”
Cameron’s case is important in genetics, partly because it may supply evidence that pseudogenes are more significant than they were previously thought to be.
“}}
Limits to economic growth | Nature Physics
December 24, 2024https://www.nature.com/articles/s41567-022-01652-6
Murphy, T. W. (2022). Limits to economic growth. Nature Physics, 18(8), 844–847. https://doi.org/10.1038/s41567-022-01652-6
Bloom’s 2 sigma problem – Wikipedia
December 24, 2024Rough Diamonds on Netflix
December 22, 2024E Haven Ride
December 22, 202401:21
22.7 km
16.8 km/h
130 m
130 m
26′ back from E Haven-Branford bridge to 61yo
32′ going there
The persistence of smoke VOCs indoors: Partitioning, surface cleaning, and air cleaning in a smoke-contaminated house | Science Advances
December 22, 2024https://www.science.org/doi/10.1126/sciadv.adh8263
QT:{{”
Many volatile organic compounds (VOCs) persisted days following the smoke injection, providing a longer-term exposure pathway for humans….These rates imply that vapor pressure controls partitioning behavior and that house ventilation plays a minor role in removing smoke VOCs. However, surface cleaning activities (vacuuming, mopping, and dusting) physically removed surface reservoirs and thus reduced indoor smoke VOC concentrations more effectively than portable air cleaners and more persistently than window opening.
“}}
