Posts Tagged ‘ancestry’

AncestryDNA(R) White Papers

October 29, 2018

https://support.ancestry.com/s/article/AncestryDNA-White-Papers

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Here, we augment these DNA and pedigree-based insights even further with our new Genetic Communities feature (Figure 1.1). Instead of considering the IBD connection between each pair of customers in isolation, we simultaneously analyze more than 20 billion connections identified among over 2 million AncestryDNA customers as a large genetic network (described below in Section 3). Intuitively, because the estimated IBD connections between individuals are likely due to recent shared ancestry (within the past 10 generations), broader patterns in this large network likely represent recent shared history. The result is that we can identify clusters of living individuals that share large amounts of DNA due to specific, recent shared history. For example, we identify groups of customers that likely descend from immigrants participating in a particular wave of migration (e.g. Irish fleeing the Great Famine)
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Ethnicity estimates are not an exact science. The percentage AncestryDNA reports to a customer is the most likely percentage within a range of percentages. In this section, we discuss how we calculate this range. It is important to keep in mind that here at AncestryDNA we continue to build upon our previous work to offer ever more accurate results to our customers.

So, for example, we might report someone as 40% England, Wales and Northwestern Europe with a confidence range of 30-60%. This means that they are most likely 40% England, Wales and Northwestern Europe but they could be anywhere between 30% and 60% England, Wales and Northwestern Europe.

As illustrated in Figure 4.1, our updated ethnicity estimation process, or algorithm, performs significantly better than our previous process for nine European regions. Since we are analyzing
single-origin people, a perfect algorithm would report back 100% for all of these cases. While not quite perfect, in each case, the updated algorithm is closer to 100% compared to the previous method. The trend is similar for the majority of the other regions (data not shown). …

Transition probabilities are really just the odds that an ethnicity will change from one window to the next.

The final ethnicity estimates customers receive are calculated by counting the proportion of the Viterbi path (weighted by recombination distance) that are assigned to a particular population in the reference panel.
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related
23andMe ancestry composition white paper
https://permalinks.23andme.com/pdf/23-16_ancestry_composition.pdf

Are You My Cousin?

March 20, 2017

Are You My Cousin?
http://www.NYTimes.com/2014/02/01/opinion/sunday/are-you-my-cousin.html Combination of noisy crowd-sourced #ancestry & @23andMe linkages may connect everyone in a tree

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“The farther you go back, the more quantum it gets. According to Geni, my 97th great-grandfather is King David from the Bible. So what are the chances that I’m actually a direct descendant of the Goliath slayer? Count me a highly doubting Thomas. But it’s still fun to dive into the research and try to verify it.

In addition to using crowd-sourced trees, I’m trying to build my family list with genetic testing. I recently sent my saliva off to 23andMe (the F.D.A. has suspended the health-related part of 23andMe, but the ancestry service remains open). The result? I found more than a thousand fellow spitters who share enough genetic material that 23andMe says we are probable cousins. One such distant cousin: my wife. This was a tad jarring. Not to mention that it set off an avalanche of bad inbreeding and hillbilly jokes from friends. But the truth is, my wife and I aren’t unusual.
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