https://academic.oup.com/genetics/article/211/4/1125/5931511
Visscher, P. M., & Goddard, M. E. (2019). From R.A. Fisher’s 1918 paper to GWAS a century later. Genetics, 211(4), 1125–1130.
https://doi.org/10.1534/genetics.118.301594
Posts Tagged ‘future0mg’
From R.A. Fisher’s 1918 Paper to GWAS a Century Later | Genetics | Oxford Academic
January 1, 2026Full article: Genomic Contextualism: Shifting the Rhetoric of Genetic Exceptionalism
January 1, 2026https://www.tandfonline.com/doi/full/10.1080/15265161.2018.1544304
Human genome exceptionalism is the idea that genetic information is uniquely powerful, personal, and different from other medical data, requiring special legal and ethical protections, but many argue this view is outdated, hindering research and policy by treating genetics as fundamentally separate rather than as an intimate, but contextual, part of a person’s health information
The human disease network | PNAS
January 1, 2026https://www.pnas.org/doi/10.1073/pnas.0701361104?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub++0pubmed QT:{{” We find that essential human genes are likely to encode hub proteins and are expressed widely in most tissues. This suggests that disease genes also would play a central role in the human interactome. In contrast, we find that the vast majority of disease genes are nonessential and show no tendency to encode hub proteins, and their expression pattern indicates that they are localized in the functional periphery of the network. “}}
Goh, K., Cusick, M. E., Valle, D., Childs, B., Vidal, M., & Barabási, A. (2007). The human disease network. Proceedings of the National Academy of Sciences, 104(21), 8685–8690.
https://doi.org/10.1073/pnas.0701361104
POSTER: ‘Human Knockout Project’ in a Pakistani Population with High Levels of Consanguinity – Mass General Advances in Motion
January 1, 2026Darwin Machines and the Nature of Knowledge – Henry Plotkin – Google Books
January 1, 2026https://books.google.com/books/about/Darwin_Machines_and_the_Nature_of_Knowle.html?id=Q6vsdBdWkc8C QT:{{” Learn and survive. Behind this simple equation lies a revolution in the study of knowledge, which has left the halls of philosophy for the labs of science. This book offers a cogent account of what such a move does to our understanding of the nature of learning, rationality, and intelligence. Bringing together
evolutionary biology, psychology, and philosophy, Henry Plotkin presents a new science of knowledge, one that traces an unbreakable link between instinct and our ability to know. Contrary to the modern liberal idea that knowledge is something derived from experience, this science shows us that what we know is what our nature allows us to know, what our instincts tell us we must know. Since our ability to know our world depends primarily on what we call intelligence, intelligence must be understood as an extension of instinct. Drawing on contemporary evolutionary theory, especially notions of
hierarchical structure and universal Darwinism, Plotkin tells us that the capacity for knowledge, which is what makes us human, is deeply rooted in our biology “}}
what is car t therapy – Google Search
January 1, 2026https://www.google.com/search?q=what+is+car+t+therapy&oq=what+is+CAR+T+ther&gs_lcrp=EgZjaHJvbWUqBwgAEAAYgAQyBwgAEAAYgAQyBggBEEUYOTIHCAIQABiABDIHCAMQABiABDIHCAQQABiABDIHCAUQABiABDIHCAYQABiABDIHCAcQABiABDIICAgQABgWGB4yCAgJEAAYFhge0gEIOTQ2MGowajeoAgCwAgA&sourceid=chrome&ie=UTF-8 QT:{{” CAR T-cell therapy (Chimeric Antigen Receptor T-cell therapy) is a personalized immunotherapy that genetically modifies a patient’s own T-cells (a type of white blood cell) in a lab to create
supercharged cancer-fighting cells, which are then infused back into the patient to find and destroy specific cancer cells, particularly effective for some blood cancers like leukemia and lymphoma that don’t respond to other treatments.
How it works:
T-cell Collection (Apheresis): Your T-cells are drawn from your blood, usually through a vein, and the rest of your blood is returned to you. Genetic Modification: In a specialized lab, a deactivated virus inserts new genes into your T-cells, creating Chimeric Antigen Receptors (CARs) on their surface, essentially turning them into “GPS-guided” missiles.
Expansion: These CAR T-cells multiply in the lab until there are millions of them.
Infusion: The lab-grown CAR T-cells are infused back into your body, often after a short course of chemotherapy to prepare you, where they hunt down and kill cancer cells.
“}}
Source: American College of Veterinary Surgeons
December 29, 2025https://www.acvs.org/large-animal/laryngeal-hemiplegia-in-horses/
Source: American College of Veterinary Surgeons Laryngeal Hemiplegia in Horses – American College of Veterinary Surgeons
https://share.google/PQvvRFHQNb4DGRAve
First Minimal Synthetic Bacterial Cell | J. Craig Venter Institute
December 29, 2025https://www.jcvi.org/research/first-minimal-synthetic-bacterial-cell QT:{{” Researchers from the J. Craig Venter Institute (JCVI) and Synthetic Genomics, Inc. (SGI) have accomplished the next feat in synthetic biology research—the design and construction of the first minimal synthetic bacterial cell, JCVI-syn3.0.
Using the first synthetic cell, Mycoplasma mycoides JCVI-syn1.0 (built by this same team in 2010), JCVI-syn3.0 was developed through a design, build, and test (DBT) process using genes from JCVI-syn1.0. The new minimal synthetic cell contains only 531,000 base pairs and just 473 genes making it the smallest genome of any self-replicating organism. “}}
Creating a functional single-chromosome yeast – PubMed
December 29, 2025https://pubmed.ncbi.nlm.nih.gov/30069045/
QT:{{” Eukaryotic genomes are generally organized in multiple chromosomes. Here we have created a functional single-chromosome yeast from a Saccharomyces cerevisiae haploid cell containing sixteen linear chromosomes, by successive end-to-end chromosome fusions and centromere deletions. The fusion of sixteen native linear chromosomes into a single chromosome results in marked changes to the global three-dimensional structure of the chromosome due to the loss of all centromere-associated inter-chromosomal interactions, most
telomere-associated inter-chromosomal interactions and 67.4% of intra-chromosomal interactions. However, the single-chromosome and wild-type yeast cells have nearly identical transcriptome and similar phenome profiles. The giant single chromosome can support cell life, although this strain shows reduced growth across environments, competitiveness, gamete production and viability. “}}
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