Posts Tagged ‘neurosci’

Opinion | Autism Rates Have Increased 60-Fold. I Played a Role in That. – The New York Times

July 6, 2025

https://www.nytimes.com/2025/06/23/opinion/why-autism-rates-increased.html

Autism Rates Have Increased 60-Fold. I Played a Role in That.

June 23, 2025

By Allen Frances

Dr. Frances is a psychiatrist. He led the American Psychiatric Association’s task force charged with creating the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders.

QT:{{”

Robert F. Kennedy Jr., secretary of health and human services, is correct that reported autism rates have exploded in the last 30 years — they’ve increased roughly 60-fold — but he is dead wrong about the causes. I should know, because I am partly responsible for the explosion in rates.

The rapid rise in autism cases is not because of vaccines or environmental toxins, but rather is the result of changes in the way that autism is defined and assessed — changes that I helped put into place.

In the late 1980s and early 1990s, I was the chair of the task force charged with creating the fourth edition of the Diagnostic and Statistical Manual of Mental Disorders, or the D.S.M.-IV. Sometimes called the “bible of psychiatry,” the D.S.M. influences medical practice, insurance coverage, education and treatment selection.

In the third edition of the D.S.M., published in 1980, autism was tightly defined and considered extremely rare. Criteria for the diagnosis required a very early onset (before age 3) of severe cognitive, interpersonal, emotional and behavioral problems.

But my task force approved the inclusion of the new diagnosis, Asperger’s disorder, which is much milder in severity than classic autism and much more common. In doing so, we were responding to child psychiatrists’ and pediatricians’ concerns for children who did not meet the extremely stringent criteria for classic autism, but had similar symptoms in milder form and might benefit from services.

Based on careful studies, our task force predicted that the addition of Asperger’s disorder would modestly increase the rate of children given an autism-related diagnosis. Instead, the rate increased more than 16-fold, to one in 150 from an estimated one in 2,500 in the span of a decade. It has been climbing more gradually ever since and is one in 31 today. Our intentions were good, but we underestimated the enormous unintended consequences of adding the new diagnosis. “}}

Parkinson’s disease could be detected by listening to someone’s voice | New Scientist

July 6, 2025

https://www.newscientist.com/article/2479755-parkinsons-disease-could-be-detected-by-listening-to-someones-voice/

Mentions:

https://www.runelabs.io/

Ananthanarayanan, A., Senivarapu, S., & Murari, A. (2025). Towards Causal Interpretability in Deep Learning for Parkinson’s Detection from Voice Data. medRxiv (Cold Spring Harbor Laboratory).
https://doi.org/10.1101/2025.04.25.25326311

https://www.medrxiv.org/content/10.1101/2025.04.25.25326311v3

The Radical Development of an Entirely New Painkiller | The New Yorker

June 23, 2025

https://www.newyorker.com/magazine/2025/06/02/the-radical-development-of-an-entirely-new-painkiller

Galchen, R. (2025, May 26). The radical development of an entirely new painkiller. The New Yorker.
https://www.newyorker.com/magazine/2025/06/02/the-radical-development-of-an-entirely-new-painkiller

Nav1.7 refers to the sodium voltage-gated channel alpha subunit 9, also known as SCN9A

A dramatic rethink of Parkinson’s offers new hope for treatment | New Scientist

June 23, 2025

https://www.newscientist.com/article/mg26635401-400-a-dramatic-rethink-of-parkinsons-offers-new-hope-for-treatment/

Mounting evidence suggests there might be two separate types of the world’s fastest-growing neurological condition. Can this fresh understanding lead to much-needed new treatments?

By Alexandra Thompson

RBD – REM disorder

interesting paper neuroscience vs LLM

June 15, 2025

very interesting paper which compares neuroscience
experiments to AI LLM and foundation models:
https://www.nature.com/articles/s42256-025-01049-z

Consciousness: The Road to Reductionism | American Scientist

March 3, 2025

https://www.americanscientist.org/article/consciousness-the-road-to-reductionism

Consciousness: the road to Reductionism. (2025, February 18). American
Scientist. https://www.americanscientist.org/article/consciousness-the-road-to-reductionism By Alan J. McComas

A World Without Pain | The New Yorker

December 26, 2024

Levy, A. (2020, January 6). A world without pain. The New Yorker. https://www.newyorker.com/magazine/2020/01/13/a-world-without-pain

QT:{{”
“When I met Jo for the first time, I was just struck by her,” Cox, an affable forty-year-old with a scruffy beard, told me, one afternoon in his lab at U.C.L. …This imperviousness to pain is what makes her distinct from everyone else with a FAAH mutation. They, like even the most committed stoners, can still get hurt.

Cameron had the same FAAH mutation that many other people have—but there had to be something else at play. The scientists started their inquiry by isolating DNA from her blood, and then analyzing the protein-coding subset of her genome—the part that’s traditionally considered to be significant. “We didn’t really find anything,” Cox said. “So we decided, O.K., why don’t we look across the whole genome for bits that are deleted or duplicated? And, at the time, this new chip was just available, which enabled us to scan the whole genome and look for deletions”—snippets missing from her genetic code. “It was a lucky strike: we found that there was this deletion. But it was distinct from FAAH. It was away from FAAH, just downstream.”

The scientists noticed that the right edge of the deletion overlapped “a gene that was annotated as a pseudogene,” Cox said, and frowned. “Which is a term I don’t like.” A pseudogene is what’s been thought of as genetic detritus—a copy of a gene that’s just sitting there, not doing anything productive. One biochemist I spoke to likened a pseudogene to a rusted-out car you stumble on in the forest—only, in Cameron’s case, they put a key in the ignition and the car turned on. “To call it a pseudogene is misleading, because this is a gene that is expressed—it makes a product, a sequence in the DNA,” Cox said, with excitement. “It’s a real fascinating class of genes which have been severely overlooked in genetics until very recently.” Cox and his colleagues named this particular pseudogene—“It’s nicer to call it a gene,” he insisted—FAAH OUT. “It was a wordplay, really,” he said sheepishly. “The challenge now is to understand what it’s doing. Jo is the first person in the world that we know of with this.”

Cameron’s case is important in genetics, partly because it may supply evidence that pseudogenes are more significant than they were previously thought to be.
“}}

AI scientists are producing new theories of how the brain learns

October 4, 2024

https://www.economist.com/science-and-technology/2024/08/14/ai-scientists-are-producing-new-theories-of-how-the-brain-learns

Neuromarketing: What You Need to Know

September 8, 2024

Some thoughts on neuromarketing.

I’d like to highlight
an article on neuromarketing by Eben Harrell. (This article is also related to content in the recent book Nita Farahany). The article talks about the emerging practice of neuromarketing, that is, ascertaining a person’s interest in buying a product or service through various neuroscience techniques. Such techniques include functional magnetic resonance imaging (fMRI) or an
electroencephalogram (EEG).

The fundamental premise behind neuromarketing is to more directly ascertain what is going on in someone’s brain. With traditional marketing approaches, like surveys, individuals’ responses are not always an accurate reflection of what is going on in their minds. This can be simply due to forgetting, but it can also be due to people feeling ashamed or uninterested in revealing their true motivations.

Potentially, neuromarketing techniques can determine whether people’s brains are stimulated by things that they don’t want to reveal. An example would be putting a product in front of a person, for instance, a sweet or salty food that they don’t want to admit they want to eat, and then visualizing in an fMRI that their minds are, in fact, stimulated by the product. Regarding the techniques, fMRI is thought of as a more accurate approach and gives a better sense of which area of the brain is activated, but it requires much more cumbersome equipment in comparison to EEG.

A more controversial aspect of neuromarketing goes beyond observing and directly tries to implant or influence people’s thinking subconsciously. The idea of subconscious suggestion has been around for a long time. However, incorporating specific neuroscience interventions goes further, such as putting ideas in people’s dreams or, instead of just monitoring the brain through something implanted on the scalp, actively trying to influence it, for instance, through transcranial magnetic stimulation (TMS).

Neuromarketing techniques, particularly those that involve directly influencing the brain but even those that just observe it, are ethically fraught, and privacy implications and issues related to free will and choice must be considered. (These are discussed in detail in Farahany (’23).) A number of the ethical issues associated with neuromarketing seem innocuous. For example, Harrell’s article indicates that research has shown that an EEG or fMRI is better able to determine what movie a person likes than focus groups or surveys. However, when one inquires instead about political preferences or party affiliation, this becomes more ethically fraught. There is a spectrum from simply looking at someone’s eye gaze or attention and trying to gauge the degree to which they are interested in something, all the way to putting them into an fMRI machine. It is difficult to know where the ethical line is crossed.

Harrell’s article also alludes to the integration of neuro-sensing devices with other devices. One can imagine a frightening scenario where the ECG in one’s Apple Watch (or maybe an EEG in future iGlasses) is connected to a neuromarketing campaign, and as one watched television or looked at products, various readings from this would be correlated. Finally, the idea of directly manipulating one’s brain with TMS or even ingested chemicals is worrisome.

Overall, I think that there is a lot of promise in neuromarketing. In a sense, it’s a natural extension of the marketer trying to ascertain exactly what the consumer wants, improving upon other marketing techniques that use only indirect proxies of what is going on in the mind. However, it crosses over into certain ethical gray zones that must be taken into account.

References

The Battle for Your Brain: Defending the Right to Think Freely in the Age of Neurotechnology , Farahany, Nita A (2023).
https://www.amazon.com/Battle-Your-Brain-Defending-Neurotechnology-ebook/dp/B09Y45MY2VLinks to an external site.

Neuromarketing: What You Need to Know
https://hbr.org/2019/01/neuromarketing-what-you-need-to-knowLinks to an external site.
Eben Harrell (2019)

True nature of consciousness: Solving the biggest mystery of your mind | New Scientist

August 31, 2024

https://www.newscientist.com/article/mg24332480-000-true-nature-of-consciousness-solving-the-biggest-mystery-of-your-mind/