Posts Tagged ‘quote’

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Trimethylamine N-oxide – Wikipedia

July 4, 2017

QT:{{”

Studies published in 2013 indicate that high levels of TMAO in the blood are associated with an increased risk of major adverse cardiovascular events.[9] The concentration of TMAO in the blood increases after consuming foods containing carnitine[10] or
lecithin[9] if the bacteria that convert those substances to TMAO are present in the gut.[11] High concentrations of carnitine are found in red meat, some energy drinks, and some dietary supplements;
‘}}
https://en.m.wikipedia.org/wiki/Trimethylamine_N-oxide

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Statin Side Effects, including Lipitor (atorvastatin) on RxList.com

July 4, 2017

QT:{{”
A peculiar cross reaction with a specific food exists with Lipitor and other “statin” drugs used to lower cholesterol. Grapefruit juice blocks special enzymes in the wall of the small intestine that actually destroy many medications, including Lipitor, and prevents their absorption into the body.
“}}

http://www.rxlist.com/script/main/mobileart-rx.asp?articlekey=87598

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How Many Grams of Fiber Should We Have Daily? | Healthy Eating | SF Gate

July 4, 2017

QT:{{”
Men who are 50 years old or younger should consume 38 grams of fiber per day, according to MayoClinic.com. Men who are 51 years old or older need 30 grams of fiber per day.
“}}

http://healthyeating.sfgate.com/many-grams-fiber-should-daily-3644.html

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FormBox: A Desktop Vacuum Former That Makes Beautiful Things

July 1, 2017

FormBox: A Desktop…Former…Makes Beautiful Things, by @TeamMayku
https://www.KickStarter.com/projects/1094489804/formbox-a-desktop-vacuum-former-that-makes-beautif 3D printouts w/ chocolate & cement + ABS, PVC…

ice too

QT:{{”
“Acrylonitrile Butadiene Styrene ABS (the stuff Lego is made from) Polystyrene PS (Commonly found in: Product packaging)
Polycarbonate PC (Commonly found in: Drinks bottles)
Polypropylene PP (Commonly found in: Buckets, spades, chairs, everything!) Polyethylene (Commonly found in: sheet and foamed sheet)
PE (Commonly found in: Insulating cases, bottles)
Polyvinyl Chloride PVC (Commonly found in: straws, plastic pipes) Acrylic PMMA (Commonly found in: Light up signs)
PETg (Commonly found in: Food safe molds)
HIPS (Commonly found in: Disposable cups)”
“}}

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Opinion | Facebook, Free Expression and the Power of a Leak

July 1, 2017

Facebook, Free Expression & the Power of a Leak, by @MargotKaminski
‏https://www.NYTimes.com/2017/06/27/opinion/facebook-first-amendment-leaks-free-speech.html Internal company choices vs. the law

QT:{{”

“But there are also crucial distinctions. Where First Amendment law protects speech about public figures more than speech about private individuals, Facebook does the opposite. If a user calls for violence, however generic, against a head of state, Facebook deems that a credible threat against a “vulnerable person.” It’s fine to say, “I hope someone kills you.” It is not fine to say, “Somebody shoot Trump.” While the government cannot arrest you for saying it, Facebook will remove the post.

These differences are to be expected. Courts protect speech about public officials because the Constitution gives them the job of protecting fundamental individual rights in the name of social values like autonomy or democratic self-governance. Facebook probably constrains speech about public officials because as a large corporate actor with meaningful assets, it and other sites can be pressured into cooperation with governments.”
“}}

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First, design for data sharing : Nature Biotechnology : Nature Research

June 20, 2017

Design for data sharing
http://www.Nature.com/nbt/journal/v34/n4/full/nbt.3516.html Issues in distributing mPower mobile dataset – no DAC, allowing donors to change preferences

QT:{{”
“This March, Sage Bionetworks (Seattle) began sharing curated data collected from >9,000 participants of mPower, a smartphone-enabled health research study for Parkinson’s disease. The mPower study is notable as one of the first observational assessments of human health to rapidly achieve scale as a result of its design and execution purely through a smartphone interface. To support this unique study design, we developed a novel electronic informed consent process that includes participant-determined data-sharing preferences. It is through these preferences that the new data—including self-reported outcomes and quantitative sensor data—are shared broadly for secondary analysis. Our hope is that by sharing these data immediately, prior even to our own complete analysis, we will shorten the time to harnessing any utility that this study’s data may hold to improve the condition of patients who suffer from this disease.

Turbulent times for data sharing

Our release of mPower comes at a turbulent time in data sharing. The power of data for secondary research is top of mind for many these days. Vice President Joe Biden, in heading President Barack Obama’s ambitious cancer ‘moonshot’, describes data sharing as second only to funding to the success of the effort. However, this powerful support for data sharing stands in opposition to the opinions of many within the research establishment. To wit, the august New England Journal of Medicine (NEJM)’s recent editorial suggesting that those who wish to reuse clinical trial data without the direct participation and approval of the original study team are “research parasites”. In the wake of colliding perspectives on data sharing, we must not lose sight of the scientific and societal ends served by such efforts.” “}}

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Immune Disorders and Autism – NYTimes.com

June 19, 2017

QT:{{”
“For people, a drug that’s safe for use during pregnancy may help. A probiotic, many of which have anti-inflammatory properties, may also be of benefit. Not coincidentally, asthma researchers are arriving at similar conclusions; prevention of the lung disease will begin with the pregnant woman. Dr. Parker has more radical ideas: pre-emptive restoration of “domesticated” parasites in everybody — worms developed solely for the purpose of correcting the wayward, postmodern immune system.

Practically speaking, this seems beyond improbable. And yet, a trial is under way at the Montefiore Medical Center and the Albert Einstein College of Medicine testing a medicalized parasite called Trichuris suis in autistic adults.

First used medically to treat inflammatory bowel disease, the whipworm, which is native to pigs, has anecdotally shown benefit in autistic children.

And really, if you spend enough time wading through the science, Dr. Parker’s idea — an ecosystem restoration project, essentially — not only fails to seem outrageous, but also seems inevitable.”
“}}

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Co-directors of newly launched Harvard Data Science Initiative discuss new era

June 19, 2017

fellowships, grants, space
QT:{{”
“DOMINICI: Because of the new advances in technology, almost every field right now has data, and more data than ever. Clearly, there’s the explosion of genetics and genomics data in the life sciences, in molecular data, as well as astronomy and economics. Even in the humanities, you can scan documents and turn it into data that you can analyze.
…
PARKES: To add some numbers to this, IBM has estimated that we’re generating more than one quintillion bytes of data a day. (A quintillion is a 10 to the 18th.)
…
DOMINICI: One of the reasons we are so excited that Harvard is launching the Data Science Initiative is because of all the advances our faculty have made in recent years. We can now describe the entire genome, define the exposome (the environmental analogue to the genome), characterize social interactions and mood via cellphone data, and can digitize historical data relevant for the humanities. ….

DOMINICI: We have launched the Harvard Data Science Postdoctoral Fellowship, which is among the largest programs of its kind, and we want to recruit talented individuals in a highly interdisciplinary ways.

…

We have also launched a competitive research fund that will catalyze small research projects around the University. Through our friends in the Faculty of Arts and Sciences and the Medical School, we’ve identified some spaces in the near term where people can get together. …

PARKES: We are launching the initiative because we want to get to a point where we have a Harvard Data Science Institute. The aspiration is that the Data Science Institute will have some physical space associated with it,
…
Then the third one I wanted to mention is privacy.
“}}
http://news.harvard.edu/gazette/story/2017/03/co-directors-of-newly-launched-harvard-data-science-initiative-discuss-new-era/

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US mental-health agency’s push for basic research has slashed support for clinical trials

June 19, 2017

QT:{{”

“This shift has been having profound impacts on mental-health research in the United States, but the magnitude of the transformation is only now coming to light. An analysis by Nature suggests that the number of clinical trials funded by the NIMH dropped by 45% between 2009 and 2015 (see ‘’). This coincides with the agency’s launch, in 2011, of the Research Domain Criteria (RDoC) — a framework for research on the mechanisms of mental illness. The NIMH’s roll-out of RDoC included asking researchers to focus more on the biological bases of behaviour — such as brain circuitry and genetics — than on the broader symptoms that clinicians typically use to define and classify mental illness.

The NIMH’s embrace of fundamental research has infuriated many clinical researchers, who see it as an attempt to invalidate their methods — and say that there is scant evidence to support the idea that using RDoC will lead to greater insight or better treatments for mental illness.”
“}}

US mental-health agency’s push for basic research has slashed support for clinical trials
http://www.nature.com/news/us-mental-health-agency-s-push-for-basic-research-has-slashed-support-for-clinical-trials-1.22145

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The lost genius of the Post Office

June 19, 2017

The lost genius of the @USPS http://Politi.co/2rOqSGM Innovator (which once pioneered pneumatics & even missile delivery), now sclerotic

QT:{{”

“The first half of the 20th century was a dynamic time for the Post Office. It immensely improved mail receipt and delivery by adopting innovations from the private sector and abroad. Train cars were designed to mesh two separate aspects of mail delivery: mail sorting and delivery. Rather than have mail delivered to a post office in a jumble and then sorted by postal clerks, clerks on rail cars sorted the mail while it was en route. Bags of sorted mail were hung on posts outside train stations and post offices without the train even needing to stop.
…

The agency even toyed with moving mail by missile. Why schlep over ground when letters could be launched through the air at 600 miles per hour? “Before man reaches the moon,” Postmaster General Arthur A. Summerfield proclaimed in 1959, “mail will be delivered within hours from New York to California, to England, to India or to Australia by guided missiles.”
…
OVERSHADOWING ALL THE invention, however, was the creeping sclerosis of the Post Office as an institution. As a monopoly, it was insulated from competitive pressures, allowing inefficiency to creep into its operations and management.
…
Things began to change in the 1960s. Postal workers unionized, and President John F. Kennedy authorized them to bargain collectively in 1962. Despite growing mail volume, the Post Office ran perennial deficits, and its investment in the guts of the system—mail receipt and sortation—lagged. The system broke down in Chicago in 1966, and 10 million pieces of mail were backlogged for days.”
“}}

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