Posts Tagged ‘quote’

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What the Web Said Yesterday – The New Yorker

August 4, 2015

The Cobweb http://www.newyorker.com/magazine/2015/01/26/cobweb 20% of URLs in journal articles suffer from reference rot. Why we need a “Digital Vellum” & Web #archive

QT:{{”
Twitter is a rare case: it has arranged to archive all of its tweets at the Library of Congress. In 2010, after the announcement, Andy Borowitz tweeted, “Library of Congress to acquire entire Twitter archive—will rename itself Museum of Crap.”
…
Last month, a team of digital library researchers based at Los Alamos National Laboratory reported the results of an exacting study of three and a half million scholarly articles published in science,
technology, and medical journals between 1997 and 2012: one in five links provided in the notes suffers from reference rot. It’s like trying to stand on quicksand.
…
Copyright is the elephant in the archive. One reason the Library of Congress has a very small Web-page collection, compared with the Internet Archive, is that the Library of Congress generally does not collect a Web page without asking, or, at least, giving notice. “The Internet Archive hoovers,” Abbie Grotke, who runs the Library of Congress’s Web-archive team, says. “We can’t hoover, because we have to notify site owners and get permissions.” (There are some
exceptions.)
…
Also, it’s riddled with errors. One kind is created when the dead Web grabs content from the live Web, sometimes because Web archives often crawl different parts of the same page at different times: text in one year, photographs in another. In October, 2012, if you asked the Wayback Machine to show you what cnn.com looked like on September 3, 2008, it would have shown you a page featuring stories about the 2008 McCain-Obama Presidential race, but the advertisement alongside it would have been for the 2012 Romney-Obama debate.
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The indulgent world of F. Scott Fitzgerald | New York Post

August 3, 2015

The indulgent world of…Fitzgerald
http://nypost.com/2015/07/18/cocktails-castles-and-canoodling-the-decadent-world-of-f-scott-fitzgerald/ What the #GreatGatsby’s E & W Egg look like now: F. Scott’s modest home at ~$3M

The real locations of West & East Egg + The Great Gatsby’s author’s real home, currently valued at $3M

QT:{{”

It was in this atmosphere of money — old and new, elegant and garish — that the idea for Fitzgerald’s most celebrated novel, “The Great Gatsby,” took shape.

The Fitzgerald house is up for sale for $2.999 million. It’s been expanded over the years, but it still looks like it did in 1922.

The Gold Coast itself does not. What was once a pastoral escape for the superrich has become a sprawling suburb, with condominiums occupying tracts of land that were once polo fields.

But the geography is the same, and here and there you can catch glimpses of places that may have inspired “The Great Gatsby.”

Fitzgerald famously named the two peninsulas that jet out into the Long Island Sound “East Egg” and “West Egg.”

He liked the word egg, calling friends “colossal eggs” and enemies “unspeakable eggs,” writes biographer Jeffrey Meyers.
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PLOS Genetics: 8.2% of the Human Genome Is Constrained: Variation in Rates of Turnover across Functional Element Classes in the Human Lineage

August 2, 2015

QT:{{”
While enriched with ENCODE biochemical annotations, much of the short-lived constrained sequences we identify are not detected by models optimized for wider pan-mammalian conservation. Constrained DNase 1 hypersensitivity sites, promoters and untranslated regions have been more evolutionarily stable than long noncoding RNA loci which have turned over especially rapidly. By contrast, protein coding sequence has been highly stable, with an estimated half-life of over a billion years (d1/2 = 2.1–5.0). From extrapolations we estimate that 8.2% (7.1–9.2%) of the human genome is presently subject to negative selection and thus is likely to be functional, while only 2.2% has maintained constraint in both human and mouse since these species diverged.
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http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1004525

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Of Bacteria and Men: The Logic of Chance by Eugene Koonin (continuation)

August 2, 2015

QT:{{”
The author goes further in discussing the evolutionary processes. He considers the view of the modern synthesis, which focuses on variation and selection, too simplistic. Hence he proposes to adopt a multifactorial view, and to recognize three modalities of evolution, so-called Darwinian (random mutation and selection), Lamarckian (directed mutation) and Wrightian (random mutation and random fixation), the latter from Sewall Wright, one of the founders of population genetics. As an example of Lamarckian modality, Koonin mentions the CRISPR system in bacteria, where ‘acquired’ modifications are transmitted in the genome (Koonin & Wolf, 2009).

Now here, if I’m not mistaken, we enter territories devoid of consensus among evolutionary biologists. (I’m not an evolutionary biologist, and I admit that the subtleties of the debate often escape me.) For instance Patrick Forterre, from the Institut Pasteur, is very critical of what he calls “the false come back of Lamarck” (Forterre, 2012). He considers the CRISPR example as misleading, and that in essence this is a Darwinian phenomenon.
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http://ofbacteriaandmen.blogspot.com/2012/09/the-logic-of-chance-by-eugene-koonin_22.html

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Live Long and Prosper

August 1, 2015

QT:{{”

Begin thinking of your investments in terms of three buckets: one for liquidity, one for longevity and one for legacy

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http://www.worth.com/index.php/component/content/article/3-grow/7469-live-long-and-prosper

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The Earthquake That Will Devastate Seattle

July 24, 2015

The Really Big One
http://www.newyorker.com/magazine/2015/07/20/the-really-big-one How the evidence has come together for huge quakes hitting #Seattle in 1700 & in the near future

The Earthquake That Will Devastate Seattle

QT:{{”

“In the Pacific Northwest, everything west of Interstate 5 covers some hundred and forty thousand square miles, including Seattle, Tacoma, Portland, Eugene, Salem (the capital city of Oregon), Olympia (the capital of Washington), and some seven million people. When the next full-margin rupture happens, that region will suffer the worst natural disaster in the history of North America.
…
In fact, the science is robust, and one of the chief scientists behind it is Chris Goldfinger. Thanks to work done by him and his colleagues, we now know that the odds of the big Cascadia earthquake happening in the next fifty years are roughly one in three. The odds of the very big one are roughly one in ten. Even those numbers do not fully reflect the danger—or, more to the point, how unprepared the Pacific Northwest is to face it. The truly worrisome figures in this story are these: Thirty years ago, no one knew that the Cascadia subduction zone had ever produced a major earthquake. Forty-five years ago, no one even knew it existed.”
…
Finally, in a 1996 article in Nature, a seismologist named Kenji Satake and three colleagues, drawing on the work of Atwater and Yamaguchi, matched that orphan to its parent—and thereby filled in the blanks in the Cascadia story with uncanny specificity. At
approximately nine o’ clock at night on January 26, 1700, a
magnitude-9.0 earthquake struck the Pacific Northwest, causing sudden land subsidence, drowning coastal forests, and, out in the ocean, lifting up a wave half the length of a continent. It took roughly fifteen minutes for the Eastern half of that wave to strike the Northwest coast. It took ten hours for the other half to cross the ocean. It reached Japan on January 27, 1700: by the local calendar, the eighth day of the twelfth month of the twelfth year of Genroku.

…
Among natural disasters, tsunamis may be the closest to being completely unsurvivable. The only likely way to outlive one is not to be there when it happens: to steer clear of the vulnerable area in the first place, or get yourself to high ground as fast as possible. For the seventy-one thousand people who live in Cascadia’s inundation zone, that will mean evacuating in the narrow window after one disaster ends and before another begins…..
..
This problem is bidirectional. The Cascadia subduction zone remained hidden from us for so long because we could not see deep enough into the past. It poses a danger to us today because we have not thought deeply enough about the future. That is no longer a problem of information; we now understand very well what the Cascadia fault line will someday do.
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UPDATED: Bristol-Myers rips up its R&D group, adding, eliminating and moving 800-plus

July 14, 2015

$BMY rips up its R&D group…800-plus [affected]
http://www.fiercebiotech.com/story/bristol-myers-rips-its-rd-group-adding-eliminating-and-moving-hundreds/2015-06-25 Trend of pruning spoke cities & growing #hub ones HT @JorgensenWL

QT:{{”
“Bristol-Myers Squibb’s big reorganization fits into the industry’s new model for R&D. Large, scattered groups are out as big
organizations gravitate toward the big hubs. GlaxoSmithKline ($GSK) and Amgen ($AMGN) have offered two recent examples of that trend, which has benefited hubs like Boston/Cambridge and the Bay Area while inflicting painful cuts in outlying areas. Biopharma companies are also concentrating on core areas, sometime shedding early-stage work–reflected in Merck’s ($MRK) recent downsizing at the newly acquired Cubist and the big asset swap that occurred between GlaxoSmithKline and Novartis ($NVS).”
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Days of Our Digital Lives

July 14, 2015

Days of Our Digital Lives by @seththoughts http://www.nytimes.com/2015/07/05/opinion/sunday/seth-stephens-davidowitz-days-of-our-digital-lives.html #Search data shows misspellings & forgotten passwords more common at night

QT:{{"
“There is some evidence that we get less sharp as the day progresses. Between 2 and 3 a.m., search rates for “forgot password” are 60 percent higher than average. They are lowest around 9 a.m. Between 2 and 3 a.m., we are more than twice as likely to misspell “facebook” as “facbook” and nearly twice as likely to misspell “weather” as “wether.””

"}}

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Henry Molaison – Wikipedia, the free encyclopedia

July 12, 2015

QT:{{”
Henry Gustav Molaison (February 26, 1926 – December 2, 2008), known widely asH.M., was an American memory disorder patient who had a bilateral medial temporallobectomy to surgically remove the anterior two thirds of his hippocampi,parahippocampal cortices, entorhinal cortices, piriform cortices, and amygdalae in an attempt to cure his epilepsy. He was widely studied from late 1957 until his death in 2008.[1][2] His case played a very important role in the development of theories that explain the link between brain function and memory, and in the development ofcognitive neuropsychology, a branch of psychology that aims to understand how the structure and function of the brain relates to specific psychological processes. He resided in a care institute located in Windsor Locks, Connecticut, where he was the subject of ongoing investigation.[3]
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https://en.m.wikipedia.org/wiki/Henry_Molaison

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Temporal lobe – Wikipedia, the free encyclopedia

July 12, 2015

https://en.m.wikipedia.org/wiki/Medial_temporal_lobe

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