HITS-CLIP: panoramic views of protein-RNA regulation in living cells

December 22, 2012

Nice overview of Clipseq/HITS-CLIP
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3222227/
QT:”
This advantage relates to the mechanism of UV-mediated crosslinking, which, although incompletely understood, is believed to involve absorption of UV light by nucleic acid bases44 to induce ground state electrons to a singlet higher-energy state that enables the electron to partake in a chemical reaction in which a new covalent bond is formed…

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