https://science.sciencemag.org/content/369/6510/1501
BY CHING-LIN HSIEH, JORY A. GOLDSMITH, JEFFREY M. SCHAUB, ANDREA M. DIVENERE, HUNG-CHE KUO, KAMYAB JAVANMARDI, KEVIN C. LE, DANIEL WRAPP, ALISON G. LEE, YUTONG LIU, CHIA-WEI CHOU, PATRICK O. BYRNE, CHRISTY K. HJORTH, NICOLE V. JOHNSON, JOHN LUDES-MEYERS, ANNALEE W. NGUYEN, JUYEON PARK, NIANSHUANG WANG, DZIFA AMENGOR, JASON J. LAVINDER, GREGORY C. IPPOLITO, JENNIFER A. MAYNARD, ILYA J. FINKELSTEIN, JASON S. MCLELLAN
SCIENCE18 SEP 2020 : 1501-1505
The design of stabilizing mutations in the SARS-CoV-2 spike protein allows for high-yield production of a critical vaccine antigen.
In particular,
stabilization is very important for the Moderna vaccine design.
This work builds on :
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Science. 2013 Nov 1;342(6158):592-8. doi: 10.1126/science.1243283.
Structure-based design of a fusion glycoprotein vaccine for
respiratory syncytial virus
Jason S McLellan 1, Man Chen, M Gordon Joyce, Mallika Sastry, Guillaume B E Stewart-Jones, Yongping Yang, Baoshan Zhang, Lei Chen, Sanjay Srivatsan, Anqi Zheng, Tongqing Zhou, Kevin W Graepel, Azad Kumar, Syed Moin, Jeffrey C Boyington, Gwo-Yu Chuang, Cinque Soto, Ulrich Baxa, Arjen Q Bakker, Hergen Spits, Tim Beaumont, Zizheng Zheng, Ningshao Xia, Sung-Youl Ko, John-Paul Todd, Srinivas Rao, Barney S Graham, Peter D Kwong
Affiliations expand
PMID: 24179220 PMCID: PMC4461862 DOI: 10.1126/science.1243283 https://pubmed.ncbi.nlm.nih.gov/24179220/
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